HOME >> BIOLOGY >> NEWS
Alcoholism risk linked to gene involved in brain chemistry

Indianapolis -- A research team headed by Indiana University School of Medicine scientists has identified a gene that is strongly linked to an individual's risk of developing alcoholism.

The gene identified, GABRA2, is one of several genes that produce parts of the receptor for the brain's primary inhibitory neurotransmitter, GABA. GABA is a chemical messenger that carries information between nerve cells; when GABA binds to the GABA-receptors on a nerve cell, it inhibits the firing of that cell. GABA is known to be involved with some of the body's responses to alcohol consumption, such as loss of physical coordination, effect on mood, and alcohol withdrawal symptoms.

Alcoholism, which affects nearly 14 million Americans and can cause many social and health problems costing society an estimated $185 billion annually, is what scientists call a "complex" disease, meaning that many genes as well as environmental factors play a role in whether a person develops the disease.

While there is not one single "gene that causes alcoholism" the statistical link between this gene and the risk for alcoholism is powerful, said Howard J. Edenberg, Ph.D., Chancellor's Professor at the IU School of Medicine. Edenberg was the lead researcher for the study, which appears in the April issue of the American Journal of Human Genetics.

"Statistically, this is very strong evidence that this gene affects the risk of alcoholism," said Edenberg, professor of biochemistry and molecular biology and of medical and molecular genetics.

As researchers identify genes and brain signaling pathways associated with alcoholism -- and learn how they vary from one person to another -- opportunities should arise for development of more precisely targeted drugs, and for individualized approaches to prevent and treat alcoholism, Edenberg said.

"We may be able to target therapies and preventative treatments based on individual characteristics," he said. The res
'"/>

Contact: Eric Schoch
eschoch@iupui.edu
317-274-7722
Indiana University
15-Apr-2004


Page: 1 2

Related biology news :

1. UCSF Research Team Looking For Volunteers For Nationwide Study On Family Traits And Alcoholism
2. Genetic mutations linked to the practice of burning coal in homes in China
3. Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
4. Protein involved in childhood disorder linked to cancer
5. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
6. Gene linked to cleft lip and palate identified
7. Schizophrenia gene variant linked to risk traits
8. Gene changes linked to increased eye pressure may have implications for glaucoma therapy
9. Excess levels of nitrogen, phosphorus linked to deformed frogs
10. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
11. LBP-1a gene mutation linked to disruption of normal fetal development

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Alcoholism risk linked gene involved brain chemistry

(Date:3/31/2015)... YORK , March 31, 2015   Guidepoint ... the launch of the Post-Surgical Pain Management TRACKER, part ... products tracking usage trends in the medical device and ... access to data including treatment volumes, market share, and ... the pain associated with joint surgery. The ...
(Date:3/24/2015)... and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) has announced ... 2015-2019" report to their offering. The ... at a CAGR of 23.5 percent over the period ... and the growth prospects of the Global Iris Recognition ... size, the report considers the revenue generated from sales ...
(Date:3/24/2015)... , March 24, 2015   Crossmatch ™, ... today announced that its U.are.U ® 4500 ... Goorin Bros . to achieve PCI compliance ... secures access to the POS terminal, protecting the ... of data breaches. With one-third ...
Breaking Biology News(10 mins):Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2
(Date:4/21/2015)... RESEARCH TRIANGLE PARK, N.C. , April 21, 2015 ... announced today that it will release its first quarter ... 28, 2015. United Therapeutics will host a ... a.m. Eastern Time.  The teleconference is accessible by dialing ... the teleconference will be available for one week and ...
(Date:4/21/2015)... Whether it’s used for troubleshooting in a factory, ... Kessler CineDrive in a cinematic studio setting, or ... is designed to help any shooter create vivid high-speed ... the TS5-H offers the same convenient touchscreen controls and streamlined ... According to Tom Boldt for Fastec, “We believe that compelling ...
(Date:4/20/2015)... IL (PRWEB) April 20, 2015 ... of its 12th clinical research site: PMG Research of ... assumed operation of the clinical research department at ... outside the Southeast to a second region within the ... multi-specialty physician practice enhances PMG’s access to an additional ...
(Date:4/20/2015)... , April 20, 2015  Eli Lilly and Company ... from several targeted cancer therapies, reflecting Lilly,s diverse oncology ... Annual Meeting 2015, held April 18-22 in ... Discoveries to Patients" is the theme of this year,s ... commitment to broadening its portfolio of therapies that accelerate ...
Breaking Biology Technology:Fastec Imaging Releases the TS5-H High Definition High-Speed Camera 2Fastec Imaging Releases the TS5-H High Definition High-Speed Camera 3PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 2PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 3Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 2Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 3Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 4Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 5Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 6
Cached News: