HOME >> BIOLOGY >> NEWS
Alcoholism risk linked to gene involved in brain chemistry

Indianapolis -- A research team headed by Indiana University School of Medicine scientists has identified a gene that is strongly linked to an individual's risk of developing alcoholism.

The gene identified, GABRA2, is one of several genes that produce parts of the receptor for the brain's primary inhibitory neurotransmitter, GABA. GABA is a chemical messenger that carries information between nerve cells; when GABA binds to the GABA-receptors on a nerve cell, it inhibits the firing of that cell. GABA is known to be involved with some of the body's responses to alcohol consumption, such as loss of physical coordination, effect on mood, and alcohol withdrawal symptoms.

Alcoholism, which affects nearly 14 million Americans and can cause many social and health problems costing society an estimated $185 billion annually, is what scientists call a "complex" disease, meaning that many genes as well as environmental factors play a role in whether a person develops the disease.

While there is not one single "gene that causes alcoholism" the statistical link between this gene and the risk for alcoholism is powerful, said Howard J. Edenberg, Ph.D., Chancellor's Professor at the IU School of Medicine. Edenberg was the lead researcher for the study, which appears in the April issue of the American Journal of Human Genetics.

"Statistically, this is very strong evidence that this gene affects the risk of alcoholism," said Edenberg, professor of biochemistry and molecular biology and of medical and molecular genetics.

As researchers identify genes and brain signaling pathways associated with alcoholism -- and learn how they vary from one person to another -- opportunities should arise for development of more precisely targeted drugs, and for individualized approaches to prevent and treat alcoholism, Edenberg said.

"We may be able to target therapies and preventative treatments based on individual characteristics," he said. The res
'"/>

Contact: Eric Schoch
eschoch@iupui.edu
317-274-7722
Indiana University
15-Apr-2004


Page: 1 2

Related biology news :

1. UCSF Research Team Looking For Volunteers For Nationwide Study On Family Traits And Alcoholism
2. Genetic mutations linked to the practice of burning coal in homes in China
3. Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
4. Protein involved in childhood disorder linked to cancer
5. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
6. Gene linked to cleft lip and palate identified
7. Schizophrenia gene variant linked to risk traits
8. Gene changes linked to increased eye pressure may have implications for glaucoma therapy
9. Excess levels of nitrogen, phosphorus linked to deformed frogs
10. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
11. LBP-1a gene mutation linked to disruption of normal fetal development

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Alcoholism risk linked gene involved brain chemistry

(Date:4/17/2014)... German . Our ... provide us with a continuous stream of information about our ... still in a car the world glides by us ... without effort, our brain calculates self-motion from this "optic flow". ... steady gaze during our own movements. Together with biologists from ...
(Date:4/17/2014)... German . If ... of him, he can expect his premises to be trashed. ... the consequences is enough to make restaurant owners pay up. ... their eggs in other birds, nests. If the host birds ... revenge by destroying the entire nest. Consequently, it is beneficial ...
(Date:4/17/2014)... painted a stark warning on the possible effects of ... effect 32 times that of carbon dioxide. Now a ... act as fully regenerable electron acceptors which helps explain ... instead of being released to the atmosphere. However, there ... may enter into a vicious cycle to release large ...
Breaking Biology News(10 mins):How vision makes sure that little fish do not get carried away 2How vision makes sure that little fish do not get carried away 3How vision makes sure that little fish do not get carried away 4Fear of the cuckoo mafia 2Fear of the cuckoo mafia 3Methane climate change risk suggested by proof of redox cycling of humic substances 2
(Date:1/15/2014)... AudioNotch is the internet's leading provider ... treatment of tinnitus. Patients listen to sound therapy that ... period of weeks to months, their tinnitus volume decreases. , ... Notched Music and Notched White Noise. Now, AudioNotch is pleased ...
(Date:1/14/2014)... 2014  3D Communications, a leading provider of strategic communications services to ... events in the United States and ... Cox , JD, is returning to the firm,s Washington, ... 3D after more than two years of service as Associate Commissioner ...
(Date:1/14/2014)... January 14, 2014 iLab Solutions, the leader ... the new Director of Product Strategy. In this role, Michelle ... iLab sub-teams to guide in the development of iLab products. ... the maximum possible benefit to the scientific community by offering ...
(Date:1/14/2014)... 13, 2014 Bob Hainsey, a semiconductor ... 20 years in the industry, has joined SPIE, ... will serve as the society’s Science and Technology Strategist. ... SPIE as our Technology Strategist, further strengthening the technical ...
Breaking Biology Technology:Former FDA Associate Commissioner Returns To 3D Communications 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2
Cached News: