HOME >> BIOLOGY >> NEWS
Alcoholism risk linked to gene involved in brain chemistry

Indianapolis -- A research team headed by Indiana University School of Medicine scientists has identified a gene that is strongly linked to an individual's risk of developing alcoholism.

The gene identified, GABRA2, is one of several genes that produce parts of the receptor for the brain's primary inhibitory neurotransmitter, GABA. GABA is a chemical messenger that carries information between nerve cells; when GABA binds to the GABA-receptors on a nerve cell, it inhibits the firing of that cell. GABA is known to be involved with some of the body's responses to alcohol consumption, such as loss of physical coordination, effect on mood, and alcohol withdrawal symptoms.

Alcoholism, which affects nearly 14 million Americans and can cause many social and health problems costing society an estimated $185 billion annually, is what scientists call a "complex" disease, meaning that many genes as well as environmental factors play a role in whether a person develops the disease.

While there is not one single "gene that causes alcoholism" the statistical link between this gene and the risk for alcoholism is powerful, said Howard J. Edenberg, Ph.D., Chancellor's Professor at the IU School of Medicine. Edenberg was the lead researcher for the study, which appears in the April issue of the American Journal of Human Genetics.

"Statistically, this is very strong evidence that this gene affects the risk of alcoholism," said Edenberg, professor of biochemistry and molecular biology and of medical and molecular genetics.

As researchers identify genes and brain signaling pathways associated with alcoholism -- and learn how they vary from one person to another -- opportunities should arise for development of more precisely targeted drugs, and for individualized approaches to prevent and treat alcoholism, Edenberg said.

"We may be able to target therapies and preventative treatments based on individual characteristics," he said. The res
'"/>

Contact: Eric Schoch
eschoch@iupui.edu
317-274-7722
Indiana University
15-Apr-2004


Page: 1 2

Related biology news :

1. UCSF Research Team Looking For Volunteers For Nationwide Study On Family Traits And Alcoholism
2. Genetic mutations linked to the practice of burning coal in homes in China
3. Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
4. Protein involved in childhood disorder linked to cancer
5. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
6. Gene linked to cleft lip and palate identified
7. Schizophrenia gene variant linked to risk traits
8. Gene changes linked to increased eye pressure may have implications for glaucoma therapy
9. Excess levels of nitrogen, phosphorus linked to deformed frogs
10. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
11. LBP-1a gene mutation linked to disruption of normal fetal development

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/5/2016)... , Dec. 5, 2016  The Office of ... published "Can CT Scans Enhance or Replace Medico ... potential of supporting or replacing forensic autopsies with ... scan. In response to recommendations made ... exploring using CT scans as a potential component ...
(Date:11/29/2016)... , Nov. 29, 2016 BioDirection, a ... point-of-care products for the objective detection of concussion and ... company has successfully completed a meeting with the U.S. ... Tbit™ blood test Pre-Submission Package. During the meeting company ... system as a precursor to commencement of a planned ...
(Date:11/22/2016)... 2016 According to the new market research report ... Vein, Signature, Voice), Multi-Factor), Component (Hardware and Software), Function (Contact and Non-contact), ... market is expected to grow from USD 10.74 Billion in 2015 to ... 2016 and 2022. Continue Reading ... ...
Breaking Biology News(10 mins):
(Date:12/9/2016)... MA (PRWEB) , ... December 09, 2016 , ... Aditya ... that in addition to Australia, Europe, and the United States, Axiomed is now gaining ... assure interest in this technology." , Mr. Humad went on to say that, “We ...
(Date:12/9/2016)... -- China Cord Blood Corporation (NYSE: CO ) ... provider of cord blood collection, laboratory testing, hematopoietic stem cell ... of its 2016 Annual General Meeting, which was held on ... . At the Annual General Meeting, ... Huazhen LLP as the independent auditors of the Company for ...
(Date:12/8/2016)... Board of Directors of the Pittsburgh Life Sciences ... only pure life sciences investment firm, today announced a ... developed by the Nominating and Governance Committee over the ... Jordan is selected to serve as President and ... who is elected to the position of Executive Chairman ...
(Date:12/8/2016)... Dec. 8, 2016  OncoSec Medical Incorporated ("OncoSec") ... DNA-based intratumoral cancer immunotherapies, today announced financial results ... "We are delivering on our commitment to ... ImmunoPulse® IL-12. We are pleased with the early ... trial, and we are focused on advancing our ...
Breaking Biology Technology:
Cached News: