HOME >> BIOLOGY >> NEWS
Algorithm predicts interactions between proteins whose structures are unsolved

BUFFALO, N.Y. -- A promising new algorithm that can predict interactions between proteins whose structures are unsolved has been developed by Jeffrey Skolnick, Ph.D., University at Buffalo Distinguished Professor and director of the Center of Excellence in Bioinformatics.

The research is published in today's (Nov. 15, 2002) issue of Proteins.

Called MULTIPROSPECTOR, the new algorithm takes protein interaction prediction to a new level because it works on proteins on which little structural information exists, providing three-dimensional models of the protein-protein complex and identifying the amino acid residues that interact.

According to Skolnick, the new method takes the entire field of structural genomics an important step closer to the ultimate goal of using detailed information about genes and the proteins they encode to design more effective pharmaceuticals.

"The overall goal," he said, "is to develop personalized medicine, which is based on understanding how a drug affects you versus how it affects me."

He noted: "With this paper, we are moving toward an understanding of how the whole system works, what's known as systems biology, which is the key revolution in the post-genomic era," he explained.

According to Skolnick, complexes of interacting proteins provide exciting and novel targets for potential new drugs.

"Right now, very few drugs exist that inhibit protein-protein interactions; most work against single molecules," he said.

But, he noted, the Protein Data Bank, the international "public library" of solved protein structures from which scientists draw data, contains not just isolated molecules, but in many instances solved compounds of two or more proteins interacting.

"Lots of cellular signals are mediated by these protein-protein interactions," he said, "and we want to know exactly who's interacting with whom. Often, the function of one protein can be deduced by s
'"/>

Contact: Ellen Goldbaum
goldbaum@buffalo.edu
716-645-5000 x 1415
University at Buffalo
12-Nov-2002


Page: 1 2

Related biology news :

1. Algorithms help diagnose cancer
2. Hardy buoys: Texas A&M project predicts oil spill movements
3. New tool predicts how long pollutants will stay in soil
4. Molecular marker predicts success of breast cancer treatment
5. Is that plant a tortoise or a hare? Answer predicts its response to environmental change
6. Brain signal predicts working memory prowess
7. New software developed at Rensselaer predicts promising ingredients for new drugs
8. Immunity gene predicts severe adverse drug reaction
9. New map predicts where wolves will attack
10. Study predicts conditions for sustainable lion trophy hunting
11. Inflammation marker predicts colon cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... June 23, 2020 , ... ... healthcare, and Renovagen Ltd, a UK supplier and manufacturer of innovative portable renewable ... testing operations in the fight against the COVID-19 pandemic in Zambia. , One ...
(Date:6/23/2020)... ... June 23, 2020 , ... Rigaku Corporation , a ... in a series of TOPIQ webinars, which will cover the Transferable Aspherical Atom ... in response to social distancing measures that resulted in postponements and cancelations of ...
(Date:6/19/2020)... ... June 16, 2020 , ... The director of stem cell ... if the stem cell medicine and pharmaceutical industries have easier access to stem cell ... starting July 5 of this year, Independence Day weekend in the U.S., Asymmetrex is ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra , a ... and food industries, is pleased to announce that Charles Galea has joined its ... , Charles is an accomplished and results-driven sales executive with over 10 years ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... is commonly used to suppress pigment formation in zebrafish embryos, maintaining optical transparency ... led by Dr MA has been using the zebrafish model to investigate the ...
(Date:7/7/2020)... ... 2020 , ... Bio-IT World has announced the winners of ... University of Chicago, Massachusetts General Hospital, Mission: Cure, and the Pistoia Alliance were ... outstanding examples of how technology innovations and strategic initiatives can be powerful forces ...
(Date:7/1/2020)... ... June 30, 2020 , ... ... the launch of a new clinical diagnostics immuno-oncology service, TissueInsight . ... (TME). , “Flagship’s TissueInsight is a service that aids pathologists, oncologists, and ...
Breaking Biology Technology:
Cached News: