HOME >> BIOLOGY >> NEWS
Alterations in vitamin D receptor gene increase prostate, breast cancer risk

Subtle differences in the receptor for vitamin D reverse the anti-cancer action of the sunshine vitamin, increasing the risk of breast cancer in Caucasian women and prostate cancer in African-American men, according to two new studies.

The results, in journals published by the American Association for Cancer Research, underscore how naturally-occurring variants of the same gene, called polymorphisms, can have implications for cancer initiation and progression.

For example, in the breast cancer study, British scientists at St. George's Hospital Medical School in London found that Caucasian women who carried specific versions of the vitamin D receptor gene, or VDR, not only experienced increased risk for this cancer but may also be more prone to developing metastases.

"Differences in the gene sequence for the vitamin D receptor are associated with breast cancer risk and may also be linked to disease progression" said Kay Colston, Ph.D., the senior author of the study, published in the August 15 issue of Clinical Cancer Research. Colston is a Reader in the Department of Cellular and Molecular Medicine at St. George's Hospital Medical School.

Among three known variable regions of the VDR gene considered by the research team, the bb and LL variants increased breast cancer risk by almost twofold. The F variant of the gene had no significant effect on breast cancer risk by itself, however when coupled with the LL genotype the risk of breast cancer was increased by a higher factor than the bb or LL genotypes alone. In addition, there was a higher proportion of women with this 'at risk' genotype in a sub-group of patients who developed metastatic disease.

A second study, conducted independently, linked a similar change in the vitamin D receptor (VDR) with amplified risk of prostate cancer for African American men. That study appeared in the August issue of Cancer Epidemiology, Biomarkers & Prevention, a sister publication to Clinic
'"/>

Contact: Russell Vanderboom, PhD
vanderboom@aacr.org
215-440-9300
American Association for Cancer Research
6-Aug-2004


Page: 1 2

Related biology news :

1. Genetic Alterations Linked To Cancer In Some Blood Samples
2. Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
3. Chemical derived from vitamin-E shows early promise as cancer drug
4. Folic acid vitamin use by women reaches all-time high, March of Dimes survey finds
5. Could vitamins raise levels of bad cholesterol? Animal study suggests they might
6. New antioxidants are 100 times more effective than vitamin E
7. Study finds huge variability in vitamin E absorption
8. People with undetermined muscle/bone pain tend to be severely vitamin D deficient
9. Daily vitamins could prevent vision loss among thousands
10. Drug that mimics vitamin D hormone may boost effectiveness of prostate cancer treatment
11. Strategies to boost womens multivitamin use fall short

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/30/2017)... Today, American Trucking Associations announced Seeing ... and eye tracking software, became the newest member ... "Artificial intelligence and advanced sensing algorithms ... driver,s attentiveness levels while on the road.  Drivers ... fatigue and prevent potential accidents, which could lead ...
(Date:5/16/2017)... 16, 2017  Veratad Technologies, LLC ( www.veratad.com ), ... and identity verification solutions, announced today they will participate ... May 15 thru May 17, 2017, in ... Trade Center. Identity impacts the lives ... today,s quickly evolving digital world, defining identity is critical ...
(Date:4/19/2017)... 19, 2017 The global military ... is marked by the presence of several large global ... by five major players - 3M Cogent, NEC Corporation, ... for nearly 61% of the global military biometric market ... the global military biometrics market boast global presence, which ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , ... October 11, 2017 , ... Personal eye wash is a basic first aid ... at a time. So which eye do you rinse first if a dangerous substance enters ... Plum Duo Eye Wash with its unique dual eye piece. , “Whether its dirt ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are ... 5.5 million people each year. Especially those living in larger cities are affected by ... in one of the most pollution-affected countries globally - decided to take action. , ...
(Date:10/10/2017)... ... October 10, 2017 , ... For the second time in ... STEM Mentoring Award. Representatives of the FirstHand program travelled to Washington, D.C. Tuesday, ... , US2020’s mission is to change the trajectory of STEM education in America ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program Committee ... honoring scientists who have made outstanding contributions to analytical chemistry and applied ... the world’s leading conference and exposition for laboratory science, which will be held ...
Breaking Biology Technology:
Cached News: