HOME >> BIOLOGY >> NEWS
Alzheimer's Disease And Developmental Biology Linked Through Single Molecule

Researchers at the University of Pennsylvania Medical Center and other institutions have uncovered a biochemical connection between presenilin, a molecule involved in the development of Alzheimer's disease, and another protein that controls crucial aspects of developmental biology. The findings are likely to lead to a new synergy between the two research areas and important advances in understanding on both fronts in the coming years. Reports on four related studies from the Penn team and three other groups will appear in the April 8 issue of Nature.

"The hope is that work in Alzheimer's disease will help inform people studying aspects of developmental biology about what might be going on in their neck of the woods and vice versa," says Mark E. Fortini, Ph.D., an assistant professor of genetics and senior author on one of the papers. "Once you find a common connection between two apparently disparate areas of biology, it can be very powerful in turning your eye on candidate ideas you may want to explore from the other discipline."

The scientists think that presenilin is involved in the processing of two proteins called Notch and amyloid precursor protein (APP). Mutations in the genes that codes for presenilin lead to misprocessing of Notch and APP so that the resulting proteins either cannot do their assigned jobs properly or actively damage cells. Problems with Notch disturb normal development in myriad ways and have even been implicated in one form of T-cell leukemia. Misprocessed APP is thought to produce the variant amyloid protein that dominates the plaques characteristic of Alzheimer's disease.

Notch, first discovered in fruit flies just before World War I, is involved in critical intercellular signaling in a wide array of development processes, many to do with the patterning of tissues. As the embryo develops, progenitor cells must differentiate from each other and take up different duties, a process that involv
'"/>

Contact: Franklin Hoke
hokef@mail.med.upenn.edu
215-662-2560
University of Pennsylvania School of Medicine
8-Apr-1999


Page: 1 2 3

Related biology news :

1. Alzheimers disease is not accelerated aging
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. TANGO: towards faster prognosis of Alzheimers and Parkinsons diseases?
4. DHA-rich diet protects brain from Alzheimers damage, UCLA study shows
5. Decreasing toxins in brains of Alzheimers patients keep cognitive deficits at bay
6. Early clinical treatment can halt progression of Alzheimers disease, UCI researchers find
7. New UCF researchers, college will help fight Alzheimers disease, cancer
8. Herpes tool allows researchers to customize Alzheimers vaccine
9. Altered protein involved in a novel link to Alzheimers disease
10. Alzheimers may leave some forms of memory intact
11. Cancer drug resistance research leads to possible therapeutic target for Alzheimers disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/25/2019)... (PRWEB) , ... April 24, 2019 , ... ... Human Services Secretary Alex Azar today, a broad collective of 62 individual scientists, ... the American Society of Gene & Cell Therapy (ASGCT), across industry and academia ...
(Date:4/25/2019)... Ohio (PRWEB) , ... April 25, 2019 , ... ... agents, as well as screening tools, has strengthened its commitment to meeting today’s ... be used in any application where inhibition of its targeted proteases is needed. ...
(Date:4/18/2019)... , ... April 18, 2019 , ... ... industry, today announced the launch of mSource® AI Contract Text Analysis. This contract ... of Medpricer customers’ supplier contracts, truly optimizing purchased services spend at record speed. ...
Breaking Biology News(10 mins):
(Date:4/9/2019)... ... April 09, 2019 , ... The American Society of Gene ... Society's leadership team, including a new addition to the presidential line of succession, at ... to join the Society's leadership team for a three-year term (2019-2021). , All five ...
(Date:4/8/2019)... ... April 09, 2019 , ... ... non-profit research center Chan Zuckerberg Biohub (CZ Biohub) has chosen Geneious Biologics to ... is part of CZ Biohub’s efforts to establish new approaches to inform the ...
(Date:3/29/2019)... VIEW, Calif. (PRWEB) , ... March 28, 2019 ... ... achievement of development and testing milestones, CARB-X has proceeded with a second stage ... receive up to $1.7 million, which is on top of the $1.7 million ...
(Date:3/27/2019)... ... March 27, 2019 , ... Lachman is sponsoring the event ... Hotel Burlington Road, Dublin, Ireland. The executive team on site will be available to ... key tracks on the agenda this year. , Executives from Lachman participating at this ...
Breaking Biology Technology:
Cached News: