HOME >> BIOLOGY >> NEWS
Alzheimer's Disease And Developmental Biology Linked Through Single Molecule

Researchers at the University of Pennsylvania Medical Center and other institutions have uncovered a biochemical connection between presenilin, a molecule involved in the development of Alzheimer's disease, and another protein that controls crucial aspects of developmental biology. The findings are likely to lead to a new synergy between the two research areas and important advances in understanding on both fronts in the coming years. Reports on four related studies from the Penn team and three other groups will appear in the April 8 issue of Nature.

"The hope is that work in Alzheimer's disease will help inform people studying aspects of developmental biology about what might be going on in their neck of the woods and vice versa," says Mark E. Fortini, Ph.D., an assistant professor of genetics and senior author on one of the papers. "Once you find a common connection between two apparently disparate areas of biology, it can be very powerful in turning your eye on candidate ideas you may want to explore from the other discipline."

The scientists think that presenilin is involved in the processing of two proteins called Notch and amyloid precursor protein (APP). Mutations in the genes that codes for presenilin lead to misprocessing of Notch and APP so that the resulting proteins either cannot do their assigned jobs properly or actively damage cells. Problems with Notch disturb normal development in myriad ways and have even been implicated in one form of T-cell leukemia. Misprocessed APP is thought to produce the variant amyloid protein that dominates the plaques characteristic of Alzheimer's disease.

Notch, first discovered in fruit flies just before World War I, is involved in critical intercellular signaling in a wide array of development processes, many to do with the patterning of tissues. As the embryo develops, progenitor cells must differentiate from each other and take up different duties, a process that involv
'"/>

Contact: Franklin Hoke
hokef@mail.med.upenn.edu
215-662-2560
University of Pennsylvania School of Medicine
8-Apr-1999


Page: 1 2 3

Related biology news :

1. Alzheimers disease is not accelerated aging
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. TANGO: towards faster prognosis of Alzheimers and Parkinsons diseases?
4. DHA-rich diet protects brain from Alzheimers damage, UCLA study shows
5. Decreasing toxins in brains of Alzheimers patients keep cognitive deficits at bay
6. Early clinical treatment can halt progression of Alzheimers disease, UCI researchers find
7. New UCF researchers, college will help fight Alzheimers disease, cancer
8. Herpes tool allows researchers to customize Alzheimers vaccine
9. Altered protein involved in a novel link to Alzheimers disease
10. Alzheimers may leave some forms of memory intact
11. Cancer drug resistance research leads to possible therapeutic target for Alzheimers disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2019)... ... January 17, 2019 , ... The possibility that ethnic differences ... documented for many years. These observed differences may be manifest in alterations in ... patients residing in different geographic regions. This created the perceived necessity to fully ...
(Date:1/14/2019)... ... January 14, 2019 , ... ... detect precancer and cancer cells in blood, will present new findings at the ... the fight against colorectal cancer. The results from this study show CellMax Life’s ...
(Date:1/10/2019)... ... ... Dr. Beanlands is the Vered Chair and Division Head of Cardiology at the ... of its National Cardiac PET Centre, and Professor in the University's Division of Cardiology ... of Cellular and Molecular medicine. , He is a founding member of ASNC, member ...
Breaking Biology News(10 mins):
(Date:1/20/2019)... YORK (PRWEB) , ... January 17, 2019 , ... ... clinical testing was, until recently, the exclusive purview of physicians. That's changing as ... The global direct to consumer (DTC) laboratory testing market totaled $208 million in ...
(Date:1/20/2019)... ... January 17, 2019 , ... ... Partner announces the launch of a specialized automation technology, titled Automate 3D. Automate ... automatic generation of models and drawings to deliver to end-users, customers, and ERP ...
(Date:1/15/2019)... Ill. (PRWEB) , ... January 15, 2019 , ... Personalized ... factors for worsening kidney disease, according to a new study published in the journal ... and are frequently treated with partial nephrectomy, a surgical procedure in which the tumor ...
(Date:1/11/2019)... ... January 11, 2019 , ... Boekel Scientific launches its ... donor blood. This advanced and intuitive medical device was designed in conjunction ... needed for the busiest donor stations with new-to-the industry features to improve efficiency ...
Breaking Biology Technology:
Cached News: