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Alzheimer's Disease And Developmental Biology Linked Through Single Molecule

apers show a promising link between the fields of Alzheimer's disease neuropathology and developmental biology.

"What we can learn from the effect of presenilin on the cleavage of Notch may be directly applicable to better understanding APP processing, leading to new insights into the causes of Alzheimer's disease," says Virginia M.-Y. Lee, PhD, a professor of pathology and laboratory medicine and codirector of Penn's Center for Neurodegenerative Disease Research.

"We now see a common theme to what presenilin is doing in development and in Alzheimer's disease," Fortini says. "Presenilin is required for the processing, cutting, and function of critical proteins in both areas, and defects in presenilin can lead to developmental problems in the one case and to neurological disease in the other."

Graduate student Yihong Ye is the lead author on the Nature study from Fortini's laboratory, and Nina Lukinova, PhD, is a coauthor. The work was supported by grants from the National Institutes of Health and the Alzheimer's Association.


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Contact: Franklin Hoke
hokef@mail.med.upenn.edu
215-662-2560
University of Pennsylvania School of Medicine
8-Apr-1999


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