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Alzheimer's disease may originate in the brain's white matter

ested solution was to increase the output of coal-fired plants. But the state's infrastructure power lines, transfer stations, etc. would be unable to carry the extra power, thus negating any potential benefits. So it is with the brain's transmission infrastructure: the white matter.

The researchers found two other interesting relationships. Women tended to have more alterations in their white matter than men, a finding consistent with the general predominance of Alzheimer's cases in women. An increased level of apolipoprotein E, which has been associated with higher risk of Alzheimer's, also showed a correlation with greater demyelination.

Roher says he hopes that Alzheimer's researchers will expand their area of interest to include white matter: "Only if the full extent of Alzheimer's disease pathology is known will present attempts to intervene in the progression of the disease have any reasonable chance of success."


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Contact: Beverly Hassell
b_hassell@acs.org
202-872-4065
American Chemical Society
18-Sep-2002


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