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Alzheimer's genetic susceptibility could bring fear and misunderstanding, religious scholars say

ifficult to interpret, so much so that genetic counselors would be hard pressed to provide any valid risk information to at-risk individuals.
  • (b) The information provided would be of no medical use to the tested individual, since there are currently no proven preventive interventions available.
  • (c) Tested individuals, if carrying the susceptibility gene, would feel unnecessary anxiety over ordinary events such as forgetting where one parked the car, when in fact many people with an e4 allele never get Alzheimer disease, and many people without the susceptibility allele do get the disease.
  • (d) Even though the susceptibility information is not predictive for anyone, it would still be legally available to long-term care insurance companies and could easily be used as the basis for refusal to provide coverage.
  • (e) Individuals who have a first-degree relative (usually a parent or sibling) with the disease are at somewhat higher than the ordinary 13% lifetime risk; just on the basis of family history, then, we already know that lifetime risk more or less doubles. It is not the case that APOE genotyping would enhance what is already known.

    • It is possible that other susceptibility genes will eventually be discovered that allow for a better definition of those at especially high risk than does the APOE genotyping. Over the past decade, several candidate loci on a variety of chromosomes, including chromosome 12, have been announced and touted as the basis for a potential genetic susceptibility test to be coupled with APOE genotyping. However, none of these other purported susceptibility loci have been able to provide further information because they too are so ill-defined and poorly understood epidemiologically.

    Yet eventually, perhaps within a decade, it may become possible to collate a number of genetic susceptibility tests (perhaps as many as a dozen or more will eventually be found) so as to tell someone, whether they have a family hi
    '"/>

    Contact: Brent Waters
    srns@science-spirit.org
    412-585-0842
    Science and Religion Information Service
    18-Jun-2001


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