American Cancer Society Grant Extended For Wistar Study Of Molecular Changes,,Leading To Cancer

Philadelphia -- Wistar scientist, George C. Prendergast, Ph.D., has been awarded a one-year extension on an American Cancer Society grant supporting his laboratory's research into the molecular changes that cause normal cells to become cancerous.

One aspect of Dr. Prenedergast's research focuses on a cancer-causing gene, called Myc, which has the ability to induce malignant cell growth. Six years ago, it was discovered that, under certain conditions, Myc can also cause cell suicide.

"This dual function," explains Dr. Prendergast, "means Myc may be a potential Achilles' heel in the tumor cell that harbors it. But to determine whether the killing aspects of Myc can be used for therapeutic interventions, it is first necessary for us to determine how Myc kills cells."

To gather this information, Dr. Prendergast and his research team are studying the molecules that seem to affect Myc's death signal, including a new gene product called Bin1. "Since Bin1 is frequently missing or altered in tumor cells," explains Dr. Prendergast, "it is possible that its absence may affect Myc's cell killing power."

To learn more about Bin1, Dr. Prendergast and his associates are examining its role in normal cells. They also are performing proof-of-concept experiments to determine whether malignant cells that lack Bin1 will die when Bin1 is reintroduced. Their findings are expected to provide a foundation for the design of new cancer treatments.

The American Cancer Society is the nationwide, community-based voluntary health organization dedicated to eliminating cancer as a major health problem by preventing cancer, saving lives and diminishing suffering through research, education, advocacy and service. Last year, the American Cancer Society contributed $93.3 million to research facilities throughout the country.

The Wistar Institute, established in 1892, was the first independent medical research facility in the country. For more than 100 years, Wista

Contact: Diana Cutshall
(215) 898-3716
The Wistar Institute

Page: 1 2

Related biology news :

1. Highlights of the October 2004 Journal of the American Dietetic Association
2. The American Phytopathological Society announces 2004 awards
3. Tips from the Journals of the American Society for Microbiology
4. Highlights of American Chemical Society national meeting in Philadelphia, Aug. 22-26
5. NIH roadmap for biomedical research focus of chemists at American Chemical Society meeting
6. Tips from the journals of the American Society for Microbiology
7. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
8. More aggressive breast cancer tumors found in African American women
9. American Society of Mammalogists honors CI president Russell Mittermeier with Aldo Leopold award
10. Tips from the Journals of the American Society for Microbiology
11. Most Americans not sure about the sources of high cholesterol

Post Your Comments:

(Date:8/29/2019)... ... August 29, 2019 , ... Advancements ... robotics platform in an upcoming episode, which is scheduled to broadcast 1Q/2020. Check ... and commercialization of cost-effective robotic surgical solutions for the treatment of patients suffering ...
(Date:8/27/2019)... (PRWEB) , ... August 26, 2019 , ... Shoreline ... to the strain level, has hired Bill McKenzie as its CEO and Karen Woodward ... to help Shoreline Biome meet growing demand for its products and expand the company’s ...
(Date:8/27/2019)... , ... August 27, 2019 , ... ... science and drug development. This episode is scheduled to broadcast 4Q/2019. Check local ... a biopharmaceutical research, development, investment and manufacturing company. The show will highlight how ...
Breaking Biology News(10 mins):
(Date:8/27/2019)... (PRWEB) , ... August 27, 2019 , ... Dr. Kim ... She recently opened North Peninsula Veterinary Surgical Group , a new surgical practice ... there are plans to expand and add more veterinary specialists as the practice grows. ...
(Date:8/23/2019)... ... August 22, 2019 , ... The EnozoPro® converts ordinary tap water into ... and pathogens on hard surfaces including E. Coli, Salmonella, MRSA, Listeria and Legionella. It ... more information, visit the product page at rovingblue.com , ”At Enozo, our mission is ...
(Date:8/14/2019)... COLLEGE, Pa. (PRWEB) , ... August 13, 2019 ... ... in nuclear receptor and in vitro toxicology testing solutions, announced the appointment of ... healthcare industry experience to the Board. , Mark McLoughlin will lend his healthcare ...
(Date:8/7/2019)... SOLON, Ohio (PRWEB) , ... August 07, 2019 , ... ... with a breakthrough line of soil amendments (soil “probiotics”), including Rhizolizer ® , ... within a year—the largest impact any approach has offered to date. Results from the ...
Breaking Biology Technology:
Cached News: