American Heart Association Journal Report: Gene Therapy Findings Updated: Treatment Used In Patients With Blocked Leg Vessels

DALLAS, March 31 -- A gene therapy approach to circumvent leg blood vessels obstructed by atherosclerosis that was reported last fall at the American Heart Association's Scientific Sessions has been successfully extended to a larger group of patients.

The research findings on this treatment, called therapeutic angiogenesis, are reported in today's Circulation: Journal of the American Heart Association.

The treatment, used to grow new blood vessels to bypass obstructions of blood flow in the legs of people with critical limb ischemia, was devised and is being evaluated by Jeffery Isner, M.D., at St. Elizabeth's Medical Center in Boston.

Critical limb ischemia occurs when the blood circulation in the individual's legs has become obstructed by atherosclerosis, the same disease process that creates the fat-filled plaques that clog coronary arteries, the blood vessels feeding the heart.

Isner, senior author of the Circulation paper, presented findings on the use of the gene for human vascular endothelial growth factor (VEGF) on eight patients with critical limb ischemia at the AHA conference last November. The paper reports on these eight patients.

Since submitting the paper, he has treated a total of 29 patients and in the process found two other unexpected results of the therapy.

Patients with premature atherosclerosis -- an inflammatory disease of the blood vessels of the legs which usually strikes young men -- respond well to the gene therapy. Isner says this finding is intriguing since these patients have generally been considered to be unresponsive to any therapy.

In addition, patients with sensory neuropathy -- acute loss of feeling in the feet -- have also benefited from the gene therapy. "This is surprising since a sensory neuropathy secondary to reduced blood flow to the feet, has traditionally been considered irreversible," says Isner, professor of medicine a

Contact: Brian Henry
American Heart Association

Page: 1 2 3

Related biology news :

1. Highlights of the October 2004 Journal of the American Dietetic Association
2. The American Phytopathological Society announces 2004 awards
3. Tips from the Journals of the American Society for Microbiology
4. Highlights of American Chemical Society national meeting in Philadelphia, Aug. 22-26
5. NIH roadmap for biomedical research focus of chemists at American Chemical Society meeting
6. Tips from the journals of the American Society for Microbiology
7. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
8. More aggressive breast cancer tumors found in African American women
9. American Society of Mammalogists honors CI president Russell Mittermeier with Aldo Leopold award
10. Tips from the Journals of the American Society for Microbiology
11. Most Americans not sure about the sources of high cholesterol

Post Your Comments:

(Date:3/2/2020)... ... ... Philadelphia IP law firm Panitch Schwarze Belisario & Nadel LLP is pleased to ... and Stephany G. Small, Ph.D., has joined the firm as a patent agent. ... the firm’s biotechnology and life science practice group. He has significant experience with domestic ...
(Date:2/28/2020)... ... February 27, 2020 , ... An upcoming episode of ... for maladies, such as Inflammatory Bowel Disease (IBD), specifically Crohn’s Disease (Crohn’s), and ... on a novel platform developed by Deka Biosciences, Inc. (Deka Biosciences), that will ...
(Date:2/21/2020)... MOUNTAIN VIEW, Calif. (PRWEB) , ... February 20, ... ... cell sorting and dispensing platforms, announced today that it has entered into a ... perform single cell isolation on HepaTx’s unique hepatocyte-like cells (iHeps) developed from adipose ...
Breaking Biology News(10 mins):
(Date:3/19/2020)... ... March 18, 2020 , ... Family counsellors, marriage/couples therapists, and ... insight into their perceptions of events. Imagine if a couple’s counsellor could see ... could measure the level of engagement of each individual in the therapeutic process, ...
(Date:3/10/2020)... ... March 10, 2020 , ... Ortho Clinical Diagnostics, a global leader ... announced its ORTHOTM Sera, ID-MTS, a suite of extended antigen in a gel testing ... run on ORTHO VISION® and ORTHO VISION® Max in the United States and Canada. ...
(Date:3/4/2020)... ... March 04, 2020 , ... ... services, today announced the launch of its FleXpress™ high-throughput recombinant antibody production ... of antibodies at 80 ml scale. All production occurs in Absolute Antibody’s ...
(Date:3/3/2020)... ... March 03, 2020 , ... ... to present the latest breast implant technology at the IMCAS Innovation Shark Tank ... innovations in the dermatology, plastic surgery, and aesthetic science industries that promise to ...
Breaking Biology Technology:
Cached News: