HOME >> BIOLOGY >> NEWS
Amplified genome area mapped; New gene is overexpressed in oral cancer, say Pittsburgh researchers

PITTSBURGH, Aug. 1 Investigators from the University of Pittsburgh have used a new technique to map a region of the genome chromosomal band 11q13 that is present in extra copies, or amplified, in a large percentage of oral cancers. They also have identified a new gene that is expressed at abnormally high levels in oral cancers when the segment is amplified. Their results are to be published the week of Aug. 5 online in the web version of Proceedings of the National Academy of Sciences (www.pnas.org/cgi/reprint/172285799b1).

"Gene amplification is a common and critically important genetic defect in cancer cells, and chromosomal band 11q13 appears to be one of the most frequently amplified chromosomal regions. Yet, until now, a comprehensive physical map of the band has not been published," said corresponding author Susanne M. Gollin, Ph.D., associate professor, department of human genetics, Graduate School of Public Health and director, Cytogenetics Facility, University of Pittsburgh Cancer Institute (UPCI).

"Our work represents the first time the structure of the 11q13 amplicon has been mapped so finely, enabling us to identify a new gene in this segment that is both amplified and overexpressed in oral cancer cells."

Amplification of band 11q13 appears to be a relatively common event in the development of oral and head and neck cancers, and it is usually associated with a poor prognosis. In addition to oral and head and neck cancers, amplification of the 11q13 region has been reported in breast, lung, bladder and esophageal cancers.

In this study, investigators examined 30 oral squamous cell carcinoma cell lines developed from tumors removed from patients who had not been treated previously. A new technique called quantitative microsatellite analysis (QuMA) was used to map the 11q13 amplicon, which houses about 10 genes. Of the cell lines examined, 16 (63 percent) had ampl
'"/>

Contact: Kathryn Duda
DudaK@upmc.edu
412-624-2607
University of Pittsburgh Medical Center
5-Aug-2002


Page: 1 2

Related biology news :

1. Scientists sequence genome of kind of organism central to biospheres carbon cycle
2. Keep genome data freely accessible
3. The book opens on the first tree genome
4. NSF awards 22 new projects for plant genome research
5. Milk genome symposium
6. Environmental decontamination, greenhouse gases, and the genome of a methane-loving bacterium
7. Scientists explore genome of methane-breathing microbe
8. National Academies advisory: genome data and bioterrorism
9. Adaptive changes in the genome may provide insight into the genetics of complex disease
10. Complex cells likely arose from combination of bacterial and extreme-microbe genomes
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/14/2019)... ... May 13, 2019 , ... ... 4th, at a very special Pre-EWMA 2019 event at Gothenburg’s Universeum Aquarium. Guests ... Trends, Opportunities and Innovations in Advanced Wound Care. , SmartTRAK’s Advanced Wound Care ...
(Date:5/8/2019)... ... May 07, 2019 , ... Modality ... invitation-only community for world-class CIOs, CTOs, and technology executives. Modality Solutions ... firm that guarantees confidence in a company’s cold chain. Subject-matter experts provide ...
(Date:5/8/2019)... Conn. and TORONTO (PRWEB) , ... May 08, ... ... growth recapitalization of Axiom Real-Time Metrics (“Axiom”), a premier provider of unified eClinical ... II and III clinical trials and observational studies. Axiom is a leading e-clinical ...
Breaking Biology News(10 mins):
(Date:4/8/2019)... ... April 08, 2019 , ... ... collaboration solutions, announced today the launch of their app integration solution, CT Cloud ... business and contact-orientated applications while using CT Cloud Voice and Skype for Business ...
(Date:4/4/2019)... ... April 02, 2019 , ... Biomeme, Inc. , a ... latest field-ready solution for performing PCR, RT-PCR, qPCR, and Isothermal tests called ... Rosland Franklin, an English chemist and X-ray crystallographer who made significant contributions to ...
(Date:3/27/2019)... ... March 26, 2019 , ... A leader in the ... services to veterinarians across the United States and Canada since 2004. The primary ... soft tissue injuries in the dog, cat, and horse. Recently, VetStem teamed ...
(Date:3/23/2019)... ... March 22, 2019 , ... uBiome has ... a team of researchers at Nnamdi Azikiwe University in Anambra State, Nigeria led ... PhD, of the Department of Medical Laboratory Sciences and Deputy Provost, College of ...
Breaking Biology Technology:
Cached News: