HOME >> BIOLOGY >> NEWS
Amyloid fibers sprout one step at a time

Researchers have combined sophisticated biochemical and imaging techniques to get a glimpse of the stepwise assembly of amyloid fibers in a yeast prion protein. Their findings suggest that these structured fibers form in competition with the amorphous globules that some believe may cause toxicity in amyloid diseases such as Alzheimer's and Parkinson's. The researchers say this may have important implications for those designing drugs to prevent formation of the brain-damaging proteins in those diseases.

The researchers reported their findings in the October 2004 issue of the Public Library of Science Biology. They were led by Howard Hughes Medical Institute investigator Jonathan S. Weissman at the University of California, San Francisco. HHMI investigator Ronald D. Vale, also of UCSF, was a co-author of the article.

Working in yeast, Weissman and his colleagues investigated the mechanism by which a prion protein assembles individual polypeptides into long amyloid fibers. These fibers are similar to the amyloid plaques that clog the brains of patients with Alzheimer's or Parkinson's disease.

Unlike bacteria and viruses, prions consist only of aberrant proteins that misfold into forms that, in turn, induce normal proteins to misfold. In mammalian prion infections, these abnormal, insoluble proteins trigger protein clumping, producing a plaque that can kill brain cells. In humans, clumping causes fatal brain-destroying diseases such as Creutzfeldt-Jakob disease and kuru; in animals it causes bovine spongiform encephalopathy (mad cow disease) and scrapie.

In the yeast cells Weissman and his colleagues used as research models, however, the insoluble prion merely alters a cell's metabolism. Besides offering a model for studying prions, the yeast system also provides an excellent model for the growth and aggregation of amyloid protein, said Weissman. Studying this process could have important implications for understanding amyloid diseases, h
'"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
20-Sep-2004


Page: 1 2 3

Related biology news :

1. Researchers discover protein that dissolves amyloid fibers
2. Key advance reported in regenerating nerve fibers
3. Bone marrow donor cells present in muscle fibers of boy with MD years after transplant
4. E. coli bacteria make Alzheimers-linked fibers
5. Nexia and US Army spin the worlds first man-made spider silk performance fibers
6. More useful plants may sprout from gene role discovery
7. Researchers identify signals that cause hair follicles to sprout

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/3/2020)... ... 03, 2020 , ... Accumen Inc. is helping healthcare get ... Spectrum Solutions, to provide COVID-19 saliva testing kits nationally. , “Accumen has ... than 10 years. Early in the COVID-19 crisis, we identified supply chain gaps ...
(Date:7/22/2020)... , ... July 21, 2020 , ... ... transformation and innovation in technology and compliance, announces a new solution to manage ... must ensure every layer of their technology stack complies with FDA and global ...
(Date:7/10/2020)... , ... July 08, 2020 , ... ... Cell and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July 22, 2020 • ... comparability study, but what is the most effective way to complete one? Will ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... , ... July 08, 2020 , ... ... and products, announces a significant expansion of laboratory operations through its COVID-19 ... agencies implementing testing programs. , Bode-CARES provides a turnkey solution ...
(Date:7/7/2020)... ... , ... R3 International is now offering stem cell therapy for Alzheimers dementia ... on the patient's condition, treatment may be offered IV, intrathecal or with a combination. ... Alzheimers dementia, and the incidence continues to increase as individuals live longer. There is ...
(Date:7/1/2020)... ... June 30, 2020 , ... ... announced that the launch of a new clinical diagnostics immuno-oncology service, ... tumor microenvironment (TME). , “Flagship’s TissueInsight is a service that aids pathologists, ...
(Date:6/28/2020)... ... June 26, 2020 , ... ... solutions providers, today announced its strong opposition to the recently introduced bicameral ... a blanket ban on most federal use of nearly all biometric and related ...
Breaking Biology Technology:
Cached News: