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An animal study raises additional concerns about the use of dexamethasone on premature infants

Findings published in the January 2002 edition of American Journal of Physiology -- Regulatory, Integrative, and Comparative Physiology

Bethesda, MD (February 6, 2002) -- New study results regarding the use of dexamethasone as a treatment for neonatal respiratory problems may add to existing concerns about the use of this steroid in premature infants. An animal study, carried out by a team of physiologists from the University of Michigan, has demonstrated the long-term effects of dexamethasone on stress response and behavior later in life.

Background
Dexamethasone (dex) is a therapy that neonatologists use because it improves the function of premature infants' lungs and consequently allows them to be removed from a ventilator more quickly. Although steroids have been used to treat ventilator-dependent premature infants who were developing chronic lung disease at one month of age, they have recently been used much earlier in an attempt to prevent chronic lung disease.

In January 2001, the National Institute of Child Health and Human Development (NICHD) Neonatal Research Network announced research findings stating that dexamethasone, a treatment commonly prescribed to reduce the risk of chronic lung disease in extremely premature infants, did not reduce the risk of death or chronic lung disease in these infants and may increase the risk for perforation of the intestines.

Two years earlier, the New England Journal of Medicine presented another research finding contending that infants treated with dexamethasone at two weeks of age had an infection rate that was 50 percent higher than the infants who received placebo at two weeks of age. Moreover, both groups of infants gained weight more slowly and had slower head growth while they received dexamethasone.

The Study
A study conducted at the University of Michigan was designed to develop a rat model system in which to study long-term effects of a
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Contact: Donna Krupa
djkrupa1@aol.com
703-527-7357
American Physiological Society
12-Feb-2002


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