HOME >> BIOLOGY >> NEWS
Analysis of biological clock may lead to greater understanding of human disease

(Santa Barbara, Calif.) Our biological clock, or circadian rhythm, is upset by travelling across time zones, but very soon the body adjusts to the new day/night cycle. New studies of the computational models of the circadian rhythm of fruit flies show that the internal clock is robust, that is, not easily perturbed. These studies may eventually lead to greater understanding of human jet lag as well as human disease states.

Engineers at the University of California, Santa Barbara's new Institute for Collaborative Biotechnologies and the Max Planck Institute (MPI) for Dynamics of Complex Technical Systems, in Magdeburg, Germany have analyzed the mechanism of genetic circuits by which the fruit fly regulates its circadian rhythm. The results are published in the August 30 Proceedings of the National Academies of Science. The mechanism controlling the biological clock generates a complicated dynamic behavior, oscillating back and forth and making it difficult to study, but also making it a good prototypical dynamic cellular system.

The circadian rhythm of the fruit fly is a regulatory system that takes its cues from the sun. When the sun rises it affects the light-sensitive neurons of the brain of the fruit fly, setting off reactions of proteins at a certain rate depending on the amount of light. The reactions set the clock. There are key proteins and two key feedback loops involved, making the system a hierarchical control scheme, a design tool often used in engineering.

The mechanism is called a negative feedback loop similar to that employed by an air conditioning thermostat system. It reacts when the temperature gets too cold by reducing the cooling.

The engineers are looking for the principles underlying the architecture of the fruit fly's system that enables it to be so robust, according to co-author Frank Doyle, a chemical engineer who holds UCSB's Duncan and Suzanne Mellichamp Endowed Chair in Process Control. "We are very excited about
'"/>

Contact: Gail Gallessich
gail.g@ia.ucsb.edu
805-893-7220
University of California - Santa Barbara
30-Aug-2004


Page: 1 2

Related biology news :

1. Analysis fingers causes of desertification
2. Analysis of gene expression in lymphoid cells can determine lymphoma cancer
3. Analysis uncovers critical stretches of human genome
4. Newer methods added, scope expanded in new Methods of Soil Analysis Book
5. MelTec GmbH announces new technology for High-Throughput Topological Analysis of human cells
6. Analysis of impact studies reveals how bottom fishing affects seafloor denizens
7. Analysis of flight performance in wandering albatrosses yields insights into foraging patterns of different ages and sexes
8. Analysis of Martian meteorite using unique magnetic microscope
9. Cancer-Risk Analysis Program Goes Public
10. Urine Tests Will Do Better Than Pelvic Exams To Save Teens From Serious Effects Of Sexually Transmitted Diseases, UCSF Analysis Shows
11. Farmers Can Afford To Clean Up Gulf Of Mexico, Analysis Shows

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/11/2019)... ... ... Greenberg Traurig, LLP attorneys Stephen Baird , - Marcella C. ... 9-10, at the Hyatt Regency, Minneapolis. Greenberg Traurig is a founding sponsor of DeviceTalks, ... have been featured speakers at every DeviceTalks conference since 2011. , On Sept. 9, ...
(Date:8/29/2019)... ... August 29, 2019 , ... ... breakthrough spinal robotics platform in an upcoming episode, which is scheduled to broadcast ... design, development, and commercialization of cost-effective robotic surgical solutions for the treatment of ...
(Date:8/27/2019)... Calif. (PRWEB) , ... August 27, 2019 , ... ... testing company, announced today new opportunities to improve genetic testing guidelines. In the ... to improve the guidelines to identify more at-risk patients. , Clinicians use ...
Breaking Biology News(10 mins):
(Date:8/8/2019)... ... August 08, 2019 , ... Inference Solutions , ... organizations, today announced that the company’s Studio Intelligent Virtual Agent (IVA) platform earned ... Inference will officially accept the award at Frost & Sullivan’s annual Excellence in ...
(Date:8/6/2019)... ... August 06, 2019 , ... The San ... in launching the biweekly SDBN BUZZ podcast focused on connecting the region’s biotech ... also serve to promote the region and attract external employers, investors, scientists, and ...
(Date:8/6/2019)... ... August 05, 2019 , ... Advanced Clinical, a ... a distinguished leader by PharmaVOICE magazine, earning him a prestigious spot on the ... July/August special issue. , As the executive vice president of business development and ...
(Date:8/4/2019)... ... August 02, 2019 , ... Cirtec Medical Corporation, a strategic ... announced that it has begun construction on a 30,000 sq. ft. manufacturing facility ... San Jose. , The facility, which is expected to be fully operational by ...
Breaking Biology Technology:
Cached News: