HOME >> BIOLOGY >> NEWS
Analysis of gene expression in lymphoid cells can determine lymphoma cancer

Analyzing the expression levels of the gene CDK9 (cyclin dependent kinase) and its attached molecule CYCLIN T1 in lymphoid cells in a sample of blood can accurately pinpoint lymphoma, according to researchers at Temple University's Sbarro Institute for Cancer Research and Molecular Medicine (http://www.shro.org) and the Department of Human Pathology and Oncology at the University of Siena in Italy.

Their study, "CDK9/CYCLIN T1 expression during normal lymphoid differentiation and malignant transformation," appears in the Journal of Pathology (Volume 203, Issue 4).

Lymphomas are generally difficult to diagnose since no single test currently exists to sufficiently establish their presence. Clinical practice often revolves around a pathologist looking for changes in normal lymph node architecture and cell characteristics through a series of tests, such as blood tests, x-rays, computerized tomography (CT) scans, magnetic resonance imaging (MRI) and bone marrow biopsy.

"There are many types and subtypes of lymphoma, some of which are easy to detect, but many that are very difficult to identify," says Antonio Giordano, M.D., Ph.D., director of the Sbarro Institute at Temple and one of the study's principal investigators.

The researchers found that by taking a sample of blood and doing immunohistochemical analysis for the expression of CDK9 and CYCLIN T1, they were able to accurately pinpoint the type of lymphoma--Hodgkins or non-Hodgkins--as well as its stage of advancement. Non-Hodgkins lymphoma is the sixth-most common cancer in the United States.

"Basically, this new method is a very powerful tool in determining the presence of cancer by analyzing these two molecules in the lymphoid tissue," explains Giordano, an internationally recognized researcher in the genetics of cancer and gene therapy. "The change of levels of CDK9 and CYCLIN T1 in lymphoid cells shows a correlation with activity of the cancer. T
'"/>

Contact: Preston M. Moretz
pmoretz@temple.edu
215-204-7476
Temple University
1-Sep-2004


Page: 1 2

Related biology news :

1. Analysis fingers causes of desertification
2. Analysis of biological clock may lead to greater understanding of human disease
3. Analysis uncovers critical stretches of human genome
4. Newer methods added, scope expanded in new Methods of Soil Analysis Book
5. MelTec GmbH announces new technology for High-Throughput Topological Analysis of human cells
6. Analysis of impact studies reveals how bottom fishing affects seafloor denizens
7. Analysis of flight performance in wandering albatrosses yields insights into foraging patterns of different ages and sexes
8. Analysis of Martian meteorite using unique magnetic microscope
9. Cancer-Risk Analysis Program Goes Public
10. Urine Tests Will Do Better Than Pelvic Exams To Save Teens From Serious Effects Of Sexually Transmitted Diseases, UCSF Analysis Shows
11. Farmers Can Afford To Clean Up Gulf Of Mexico, Analysis Shows

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/6/2019)... ... June 05, 2019 , ... MedTech Breakthrough , an ... and medical technology market, announced that it has selected Medacta International’s MySpine® MC ... in the 2019 MedTech Breakthrough Awards program. , Medacta® is ...
(Date:6/4/2019)... (PRWEB) , ... June 04, 2019 , ... ... manufacturing of orthopedic medical devices, today announced Q1-19 revenues of $31M, up 12% ... combined with successful roll-out of strategic investments & operational excellence initiatives worldwide. , ...
(Date:6/4/2019)... ... June 04, 2019 , ... Most preclinical EEG ... seizure risk signals, usually based on variations of amplitude, frequency or spike train ... diagnostic methodology due to the complexity and variability of the signal, and automation ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... , ... June 10, 2019 , ... ... and technology in an upcoming episode, scheduled to broadcast 4Q/2019. Check your local ... Group) and will educate viewers about how its technology facilitates laboratories to improve ...
(Date:6/11/2019)... BETHESDA, Md. and ROANOKE, Va. (PRWEB) , ... ... ... virtual care optimized for microlearning engagement, and Carilion Clinic, a national leader in ... leveraging the latest in virtual care. , Mytonomy recently deployed its ...
(Date:6/11/2019)... ... June 11, 2019 , ... A ... mesenchymal stem cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying ... on mice, MSC-EVs also increased the cells’ ability to lodge into bone marrow. ...
(Date:5/31/2019)... ... 2019 , ... For many years, the primary forms of cancer treatment have ... Advances in immuno-oncology have led to the advent of Chimeric Antigen Receptor T (CAR ... receptors known as “CARs”. The CAR enables the final product to produce chemicals in ...
Breaking Biology Technology:
Cached News: