HOME >> BIOLOGY >> NEWS
Analysis uncovers critical stretches of human genome

Hundreds of stretches of DNA may be so critical to life's machinery that they have been "ultra-conserved" throughout hundreds of millions of years of evolution. Researchers have found precisely the same sequences in the genomes of humans, rats, and mice; sequences that are 95 to 99 percent identical to these can be found in the chicken and dog genomes, as well.

Most of these ultra-conserved regions do not appear to code for proteins, but may instead play a regulatory role. Evolutionary theory suggests these sequences may be so central to mammalian biology that even small changes in them would compromise an animal's fitness.

Led by Howard Hughes Medical Institute investigator David Haussler, at the University of California at Santa Cruz, the researchers published their findings online May 6, 2004, in Science Express, the Web counterpart of the journal Science. The lead author on the paper was Gill Bejerano in Haussler's laboratory. Also co-authoring the paper were John Mattick and his colleagues from the University of Queensland in Australia.

"It's extraordinarily exciting to think that there are these ultra-conserved elements, so many of which are near well-studied genes, that weren't noticed by the scientific community before because we didn't have the comparative data that highlighted these regions," said Haussler. "The real credit goes to the prodigious efforts in sequencing these multiple genomes, which have given us this tremendous opportunity, opening our eyes to these very unusual genomic elements," he said.

According to Haussler, the researchers were launched on their analysis when initial studies hinted at major regions of conserved DNA sequences. "When we had compared the human and mouse genomes, we found that about five percent of each of these showed some kind of evolutionary selection that partially preserved the sequence," he said. "We got excited about this because only about 1.5 percent of the human genome codes for
'"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
6-May-2004


Page: 1 2 3 4

Related biology news :

1. Analysis fingers causes of desertification
2. Analysis of gene expression in lymphoid cells can determine lymphoma cancer
3. Analysis of biological clock may lead to greater understanding of human disease
4. Newer methods added, scope expanded in new Methods of Soil Analysis Book
5. MelTec GmbH announces new technology for High-Throughput Topological Analysis of human cells
6. Analysis of impact studies reveals how bottom fishing affects seafloor denizens
7. Analysis of flight performance in wandering albatrosses yields insights into foraging patterns of different ages and sexes
8. Analysis of Martian meteorite using unique magnetic microscope
9. Cancer-Risk Analysis Program Goes Public
10. Urine Tests Will Do Better Than Pelvic Exams To Save Teens From Serious Effects Of Sexually Transmitted Diseases, UCSF Analysis Shows
11. Farmers Can Afford To Clean Up Gulf Of Mexico, Analysis Shows

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... ... August 14, 2019 , ... An upcoming episode of ... microbiome therapeutics are helping to promote normal immune function in order to prevent ... educate about the DECODE.DESIGN.CURE™ technology platform, which rapidly develops microbiome therapeutics in order ...
(Date:8/14/2019)... ... ... Representatives with MyBioGate announced that China Focus@Biotech Week will be held September 10 ... connect with Chinese pharma and investors in healthcare innovation,” said Miao Guo, Vice President ... a part of Biotech Week Boston – the annual biotech festival at the No. ...
(Date:8/14/2019)... ... 13, 2019 , ... Dr. Julie Reck of Veterinary Medical Center of Fort Mill ... first stem cell patient, her own geriatric Australian Shepherd, Simon, was treated in June 2019 ... to play but his body was weak, and he struggled to play fetch and other ...
Breaking Biology News(10 mins):
(Date:9/8/2019)... NEW YORK (PRWEB) , ... September 04, 2019 ... ... New York Academy of Sciences announced today the three Winners and ... Supporting outstanding postdoctoral scientists from academic research institutions across New York, New Jersey, ...
(Date:9/4/2019)... ... September 03, 2019 , ... ... advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, gene therapies, ... & Technology will present at the upcoming Nordic Life Science Days (NLS ...
(Date:8/29/2019)... ... August 29, 2019 , ... Scientists have mapped ... they hope will ultimately help protect the multibillion-dollar grape industry that produces juice, ... Technology faculty and alumni sequenced the microbiome found within tumors of grapevines afflicted ...
(Date:8/29/2019)... ... August 29, 2019 , ... Prof. Stephen ... Sustainable Medicines in Africa program, which includes a master’s degree in biotechnology innovation ... September 2nd through 13th, 2019. Topics to be addressed include Manufacturing, Quality, ...
Breaking Biology Technology:
Cached News: