HOME >> BIOLOGY >> NEWS
Animal studies show promise treating severe chronic pain

Researchers may be on the trail of a new and more targeted treatment for severe chronic pain. In the current issue of the Journal of Clinical Investigation, a team of scientists established in a series of animal studies the therapeutic potential of selectively deleting specific nerve cells from the nervous system that convey severe chronic pain.

So effective was the treatment in eight dogs severely affected by osteroarthritis, cancer-related pain, or both, all eventually became more active and later walked with slight or no limps. Just as importantly, none showed any adverse side effects from the treatment, their temperaments were improved, and their need for other pain-controlling medications was eliminated or greatly reduced.

The authors also reported selectively deleting the nerve cells, called C-fiber neurons, from among various human neurons cultured together in the laboratory, an indication the strategy might work in people. C-fibers convey to the central nervous system sensations of noxious heat and certain inflammatory signals. "Some have referred to the technique as using a 'molecular scalpel,'" said Dr. Michael J. Iadarola, a scientist at the NIH's National Institute of Dental and Craniofacial Research (NIDCR) and a senior author on the paper. "The technique selectively deletes certain neurons but leaves others untouched. As a result, the nervous system functions normally, it's just a certain spectrum of pain responsiveness that has been deleted."

Currently, doctors have no way of selectively eliminating nerve cells involved in chronic pain. Opioid-based analgesics, the mainstay of current treatments for moderate to severe chronic pain, cannot provide universal relief, and other treatments are nonselective and/or can cause serious side effects.

Iadarola said this month's paper stems from using the old drug resiniferatoxin, or RTX, in a new way. First isolated in the 1970s, RTX is often used as a laboratory tool b
'"/>

Contact: Bob Kuska
kuskar@nidcr.nih.gov
301-594-7560
NIH/National Institute of Dental and Craniofacial Research
3-May-2004


Page: 1 2 3 4

Related biology news :

1. Animal research suggests plant estrogens in soy do not increase breast cancer risk
2. Could vitamins raise levels of bad cholesterol? Animal study suggests they might
3. UF researcher: Animals think in their own way, but unlike humans
4. Animal studies show CA4P suppresses development and induces regression of ocular neovascularization
5. Animal study demonstrates carbon monoxide may help heart patients
6. Animals can be induced to cooperate if partners reciprocate and benefits accumulate
7. Animal study finds embryonic stem cells can repair heart muscle
8. Animal welfare can now be objectively measured
9. Animals regulate their numbers by own population density
10. UF researchers score gene therapy advance: Animal study shows high blood pressure prevented in future generations
11. Experimental Staph Vaccine Broadly Protective In Animal Studies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/5/2018)... ... 04, 2018 , ... EDETEK, the premier provider of digital clinical trial platforms, ... Bethesda, MD on October 8-12, 2018. EDETEK is also a Gold Sponsor of the ... , CDISC Interchanges are global events held annually on three continents with hundreds ...
(Date:10/3/2018)... ... October 03, 2018 , ... Orbsen ... first-in-class stromal cell immunotherapies, announced that ORBCEL-M™, a second generation stromal cell ... progressive diabetic kidney disease in a four-site, pan-European Phase I/II clinical trial. ...
(Date:10/2/2018)... ... October 02, 2018 , ... The Federal Identity ... at Tampa Convention Center. The Palo Alto-based face recognition company, Camvi Technologies Inc., ... 27th. Other speakers included U.S. Federal executives from Department of Defense (DoD) and ...
Breaking Biology News(10 mins):
(Date:9/27/2018)... YORK (PRWEB) , ... September 27, 2018 , ... ... New York City, Everwell Health Solutions and SureAdhere Mobile Technology, Inc. announced they ... for medication monitoring in the battle against tuberculosis (TB) and other diseases. These ...
(Date:9/24/2018)... ... 2018 , ... ReGrow Helmet , the most advanced laser hair treatment ... for hair regrowth in the comfort of one’s home. Early campaign backers will save ... The sophisticated design and advanced technology of the ReGrow Helmet will lead the industry ...
(Date:9/22/2018)... ... September 20, 2018 , ... Catalent Pharma ... drugs, biologics and consumer health products, today announced that it will be co-hosting ... in Modern Pharmaceutical Development,”. The one-day event is to be held at the ...
(Date:9/15/2018)... YORBA LINDA, Calif. (PRWEB) , ... September 14, 2018 , ... ... we treat patients. But even with new technologies, challenges remain. In the past, the ... challenge. , St. Jude Cloud is a new data ecosystem developed to advance ...
Breaking Biology Technology:
Cached News: