HOME >> BIOLOGY >> NEWS
Animal study demonstrates carbon monoxide may help heart patients

BOSTON Carbon monoxide, the toxic gas generally associated with auto exhaust or faulty heating systems, may have a protective role in preventing the development of dangerous arteriosclerotic lesions that can clog blood vessels following balloon angioplasty or aortic transplantation.

The findings, which emerged from an animal study by researchers at Beth Israel Deaconess Medical Center (BIDMC) and the University of Pittsburgh School of Medicine, appear in the February issue of the journal Nature Medicine.

Restenosis reclogging of the heart's arteries is a vexing problem for patients who have undergone balloon angioplasty for the treatment of coronary heart disease. The condition apparently develops as a result of the angioplasty itself, in which a balloon is inserted inside the artery in order to widen the clogged vessel. If, during the procedure, the cells lining the vessel are damaged, they may become inflamed and multiply, reblocking the artery. A similar problem can occur following heart transplantation, leading to chronic graft failure, the primary reason behind organ rejection.

"These situations develop when lesions appear in between two layers of cells the vessels' endothelial cells and smooth muscle cells," explains the study's senior author, Miguel Soares, Ph.D., of the Immunobiology Research Center at BIDMC and Instructor of Surgery at Harvard Medical School (HMS). "When this happens there is extensive proliferation of the smooth muscle cells and subsequent narrowing of the blood vessel. The net result is that blood flow is decreased and in some cases stopped altogether potentially leading to a heart attack or to organ rejection."

The paradoxical idea that the poisonous gas carbon monoxide (CO) might prevent this dangerous turn of events is rooted in animal studies co-authored by Soares and Fritz Bach, M.D., director of BIDMC's Immunobiology Research Center and Lewis Thomas Professor of Surgery at HMS. Their earlier fin
'"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
23-Jan-2003


Page: 1 2

Related biology news :

1. Animal research suggests plant estrogens in soy do not increase breast cancer risk
2. Could vitamins raise levels of bad cholesterol? Animal study suggests they might
3. Animal studies show promise treating severe chronic pain
4. UF researcher: Animals think in their own way, but unlike humans
5. Animal studies show CA4P suppresses development and induces regression of ocular neovascularization
6. Animals can be induced to cooperate if partners reciprocate and benefits accumulate
7. Animal study finds embryonic stem cells can repair heart muscle
8. Animal welfare can now be objectively measured
9. Animals regulate their numbers by own population density
10. UF researchers score gene therapy advance: Animal study shows high blood pressure prevented in future generations
11. Experimental Staph Vaccine Broadly Protective In Animal Studies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2020)... ... 2020 , ... Justin Zamirowski to lead upcoming launches of ... on Type 2 diabetes and associated comorbidities. , Justin brings over 20 years ... As Chief Commercial Officer, Justin will lead Better Therapeutics’ efforts in ...
(Date:7/10/2020)... ... July 08, 2020 , ... Overcoming Comparability Issues in ... FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 p.m.-3:00 p.m. EDT, https://www.fdanews.com/cellandgenetherapy ... most effective way to complete one? Will the study comply with all FDA ...
(Date:7/2/2020)... ... July 02, 2020 , ... ... publication detailing the use of its revolutionary NEXTGENPCR endpoint thermocycler to test ... 16 minutes. The article, titled "Ultra-fast one-step RT-PCR protocol for the detection ...
Breaking Biology News(10 mins):
(Date:7/22/2020)... ... ... Join experts from Reed Tech , Gary Saner, Sr. Manager, Information Solutions Life ... webinar on Thursday, August 13, 2020 at 11am EDT (4pm BST/UK). , The ... medical devices, the NMPA has departments dealing with medical device registration (pre-market approvals) and ...
(Date:7/18/2020)... ... July 17, 2020 , ... ... the life sciences and food industries, is pleased to announce that Charles Galea ... – Business Development. , Charles is an accomplished and results-driven sales executive with ...
(Date:7/10/2020)... , ... July 09, 2020 , ... ... cell therapy, today announced the hiring of Allen R. Nissenson, M.D., F.A.C.P., as ... oversee the clinical development of Sentien’s lead product, SBI-101. Dr. Nissenson serves ...
(Date:7/1/2020)... (PRWEB) , ... June 29, 2020 , ... ... access to competitively procured purchasing contracts to its membership, recently named BioFit ... TIPS members with the opportunity to purchase ergonomic seating, cafeteria tables, book trucks ...
Breaking Biology Technology:
Cached News: