Animal study finds embryonic stem cells can repair heart muscle

ine whether implanted ES cells, derived from early embryos, could survive in injured heart muscle and improve cardiac function following heart attack. ES cells are pluripotent, meaning they have the ability to differentiate into many cell types.

To answer these questions, the researchers surgically induced myocardial infarctions in two groups of rats, one which was treated with a culture of ES mouse cells, and one treated with a "sham" culture. Prior to transplantation, the cultured ES cells were "marked" with green fluorescent protein and suspended in a medium. ES cell transplantation was then performed within 30 minutes of the MI induction; injections were made at three separate sites in the heart, one directly where the MI took place, and two in the heart muscle bordering this area. The control group of rats received an equivalent amount of medium free of ES cells at the same three sites as in the damaged heart.

Six weeks after transplantation, the researchers examined both groups of rats and found that MI damage was reduced in the animals that had been implanted with ES cells. The ES group also showed significant improvement in left ventricular function, or pumping ability. The animals in the control group did not show any improvement.

"Our results demonstrate that the engrafted ES cells survived in damaged heart muscle," says Xiao, who is Assistant Professor of Medicine at Harvard Medical School. Calculations showed that the number of "marked" cells had successfully replicated, with 7.3 percent growth of the total number of enzymatically isolated single cardiomyocytes. Most important, these cells were now rod-shaped with clear striations that mimicked heart muscle cells.

"These data strongly suggest that cardiogenesis growth of new cardiomyocytes occurred in the damaged heart muscle following ES cell transplantation," says Xiao. Measurements of the heart's left ventricular systolic pressure and diastolic pressure which reflect the heart

Contact: Jerry Berger
Beth Israel Deaconess Medical Center

Page: 1 2 3

Related biology news :

1. Animal research suggests plant estrogens in soy do not increase breast cancer risk
2. Could vitamins raise levels of bad cholesterol? Animal study suggests they might
3. Animal studies show promise treating severe chronic pain
4. UF researcher: Animals think in their own way, but unlike humans
5. Animal studies show CA4P suppresses development and induces regression of ocular neovascularization
6. Animal study demonstrates carbon monoxide may help heart patients
7. Animals can be induced to cooperate if partners reciprocate and benefits accumulate
8. Animal welfare can now be objectively measured
9. Animals regulate their numbers by own population density
10. UF researchers score gene therapy advance: Animal study shows high blood pressure prevented in future generations
11. Experimental Staph Vaccine Broadly Protective In Animal Studies

Post Your Comments:

(Date:8/6/2019)... ... August 06, 2019 , ... ... manufacturing with clinical, regulatory and GMP manufacturing experience. In November it spun ... With extensive regulatory experience and one of the first cGMP cell ...
(Date:8/6/2019)... , ... August 06, 2019 , ... ... and environmental concerns. One plant-based food in particular quickly entered the limelight – ... product developers use a thermogelling and emulsifying ingredient such as methyl cellulose. This ...
(Date:8/1/2019)... ORLANDO, Fla. (PRWEB) , ... August 01, 2019 , ... ... at the point of care. It is fully developed with over 100 units ... with applications into new fields of use, our collaboration with axiVEND will give us ...
Breaking Biology News(10 mins):
(Date:8/6/2019)... ... August 06, 2019 , ... The National Science Foundation ... a community project that will engage middle and early high school students in ... Youth-Led Citizen Science Network for Community Environmental Assessment.” Collaborative partners presenting the authentic ...
(Date:7/26/2019)... ... July 25, 2019 , ... LeadingBiotech , ... dialogue, today announces its Boston BD conference to be held on ... Biotech Week Boston , the event provides an opportunity for attendees to leverage ...
(Date:7/19/2019)... , ... July 18, 2019 , ... ... as “Ravi Everest,” will be joining forces with California-based charity Coalition Duchenne for ... July 20-22nd. Coalition Duchenne raises awareness and funding for Duchenne muscular dystrophy and ...
(Date:7/17/2019)... ARLINGTON, Va. (PRWEB) , ... July 16, 2019 ... ... cardiac markers, according to a recent report from Kalorama Information. Abbott, Roche and ... were reported in Kalorama Information’s latest report, Worldwide Market for Point-of-Care (POC) ...
Breaking Biology Technology:
Cached News: