Another job discovered for a master metabolic off-switch

DURHAM, N.C. -- Researchers have discovered that an important cellular "off-switch" that desensitizes receptors on the cell surface also regulates a second deactivation mechanism that had not been suspected before. Their finding that the off-switch, known as beta-arrestin, operates in two distinct ways hints at a broader set of regulatory roles for the molecule, said the scientists.

Receptors are proteins that nestle in the cell membrane, and which translate external chemical signals such as hormones into a cellular response. Discovering the detailed mechanisms of beta-arrestin action is important because the receptors it "downregulates" number perhaps in the thousands, and control processes throughout the body -- including heart rate; blood pressure; endocrine function; the senses of sight, smell and taste; pain tolerance, and the euphoric high of addictive drugs. Thus, new basic knowledge about the action of beta-arrestin could have implications for development of drugs for a wide array of disorders.

In an article in the October 25, 2002, "Science," Howard Hughes Medical Institute investigator Robert Lefkowitz at Duke University Medical Center and his colleagues reported their studies of the role of beta-arrestin in regulating a "second-messenger" molecule called cyclic AMP (cAMP).

This molecule launches a cascade of metabolic signals into the cell when it is produced by activation of receptors such as the "G-protein-coupled receptors" (GPCRs) studied by Lefkowitz's laboratory. The role of beta-arrestin is to desensitize GPCRs by regulating cAMP levels, to prevent over stimulation of the cell.

"It's been known for a number of years that there are two major mechanisms by which the levels of cyclic AMP are regulated," said Lefkowitz. "One is the rate at which cAMP is synthesized by an enzyme called adenylate cyclase, which in turn is activated by receptors. And the other mechanism is the rate of cyclic AMP degradation, which is carried out by a

Contact: Dennis Meredith
Duke University

Page: 1 2 3 4

Related biology news :

1. Another key for the p53 door
2. Another global warming surprise: Grasslands may become wetter as temperatures rise
3. Another transmembrane protein structure solved by Rockefeller scientists
4. Another small cog in the hub of metabolism unraveled
5. Another component of the blood clotting machinery unraveled
6. Another Case For Handwashing
7. CAK Activation Of Plant Cell Cycle: Scientists Find Another Piece In The Jigsaw Puzzle To Help Explain Why Plants Do Not Develop Cancer Spontaneously
8. Christmas Bird Count: Another Holiday Tradition
9. New hydrothermal vents discovered as South Pacific Odyssey research begins
10. A new protein is discovered to play a key role in cancer progression
11. Newly discovered protein may be key to muscular dystrophy

Post Your Comments:

(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: