HOME >> BIOLOGY >> NEWS
Another transmembrane protein structure solved by Rockefeller scientists

Chloride ion channel strikingly different from potassium kin

"Why did nature come up with such a structural plan?" ask Rockefeller University professor Roderick MacKinnon and colleagues in their Jan. 17 Nature cover article describing the three-dimensional structure of a type of chloride channel called the ClC.

The high-resolution crystallographic images published in Nature represent another instance of the Rockefeller scientists remarkable knack for visualizing the specialized proteins that provide ports of cellular entry for potassium, sodium, calcium and chloride.

MacKinnon, who is a Howard Hughes Medical Institute investigator, leads a scientific team that is adding unprecedented detail to existing descriptions of the chloride ion channel.

The research findings are seminal for what is bound to be an industry in developing drug targets for ion channel impairments. The ClC chloride channel, which is found in organisms from bacteria to humans, is linked with some heritable diseases of the muscles and kidney. Mutations in another kind of chloride channel, called the CFTR, are responsible for cystic fibrosis, the most common genetic disease in Caucasian populations.

There are many varieties of ion channels. A cousin to the chloride channel, the potassium ion channel, was structurally solved by MacKinnons group in 1998. Numerous existing drugs are known to trigger changes to the potassium ion channel, causing a potentially fatal heart disorder called Long QT syndrome. Developing biomedical solutions to the known impairments of ion channels will improve human health considerably.

The channels, also called transmembrane proteins, ingeniously shepherd vital molecules across cellular and intracellular membranes, keeping surrounding structures and biochemistry intact. Each kind of ion channel has selective features that permit only appropriately sized and charged molecules to travel to th
'"/>

Contact: Lynn Love
lovel@mail.rockefeller.edu
212-327-8977
Rockefeller University
18-Jan-2002


Page: 1 2 3

Related biology news :

1. Another key for the p53 door
2. Another global warming surprise: Grasslands may become wetter as temperatures rise
3. Another job discovered for a master metabolic off-switch
4. Another small cog in the hub of metabolism unraveled
5. Another component of the blood clotting machinery unraveled
6. Another Case For Handwashing
7. CAK Activation Of Plant Cell Cycle: Scientists Find Another Piece In The Jigsaw Puzzle To Help Explain Why Plants Do Not Develop Cancer Spontaneously
8. Christmas Bird Count: Another Holiday Tradition
9. New molecular link key to cellular proteins involved in cancer progression, other diseases
10. Researchers identify protein promoting vascular tumor growth
11. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
(Date:6/28/2020)... Fla. (PRWEB) , ... June 25, 2020 , ... In ... focus on innovations in accelerated Point of Care Testing solutions (POCT). Check local listings ... Samples are collected at medical offices and are shipped to labs throughout the country. ...
(Date:6/23/2020)... ... 23, 2020 , ... Rigaku Corporation , a global ... a series of TOPIQ webinars, which will cover the Transferable Aspherical Atom Model ... response to social distancing measures that resulted in postponements and cancelations of global ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... July 17, 2020 , ... ... firm for the life sciences and food industries, is pleased to announce that ... Clinical Research – Business Development. , Charles is an accomplished and results-driven sales ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... Technology (MIT) has expanded the company’s exclusive license to include clinical applications ... point-of-care diagnostic market, focusing initially on the SARS-CoV-2 biosensor. CANARY’s™ fast ...
(Date:7/10/2020)... , ... July 09, 2020 , ... ... cell therapy, today announced the hiring of Allen R. Nissenson, M.D., F.A.C.P., as ... oversee the clinical development of Sentien’s lead product, SBI-101. Dr. Nissenson serves ...
(Date:7/7/2020)... , ... July 06, 2020 , ... ... Awards. Entries from Roche, Eli Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts ... Bio-IT World has hosted an elite awards program, highlighting outstanding examples of how ...
Breaking Biology Technology:
Cached News: