HOME >> BIOLOGY >> NEWS
Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design

Computer-generated images of a crucial anthrax bacterium enzyme are helping to solve the mystery of how slight mutations in the shape of this protein can make it resistant to the antibiotics called sulfa drugs. These findings, by scientists at St. Jude Children's Research Hospital, appear in the September issue of Structure.

Based on these new insights into the structure of the enzyme, called DHPS, the St. Jude team has also developed a new molecule that appears likely to be able to block the enzyme's activity without triggering resistance.

DHPS normally combines the molecules DHPP and pABA during part of a biochemical pathway that produces folate, a nutrient these bacteria need to survive. Sulfa drugs are antibiotics that block pABA from binding to the enzyme, and thus block folate production.

The St. Jude findings give important clues to how the enzyme binds to DHPP and pABA. They also provide a blueprint of the enzyme that researchers can use to design more effective antibiotics against the bacterium, Bacillus anthracis. Such information is especially valuable because the anthrax bacterium is widely regarded as a potential bioterrorism weapon. The finding could also be the basis for a broad-spectrum antibiotic to treat a variety of other infections that are becoming resistant to these drugs.

The team made these discoveries by creating images of the molecular structure of DHPS using X-ray crystallography. The team bombarded crystals of the enzyme with X-rays, then used the patterns formed by the diffraction of the beams off the crystals to create computer-generated, three-dimensional images of the enzyme shape. The researchers also used this technique to make images of the enzyme bound to the two molecules that the enzyme chemically combines with to make folic acid.

Based on these images of the enzyme and its interaction with other molecules, the investigators discovered how it manipulates pABA and DHPP. In addition, the
'"/>

Contact: Bonnie Cameron
bonnie.cameron@stjude.org
901-495-4815
St. Jude Children's Research Hospital
23-Sep-2004


Page: 1 2 3

Related biology news :

1. Anthrax spores can germinate, grow and reproduce in soil
2. Anthrax research might provide more time for treatment
3. Anthrax: A soil bug gone bad
4. Anthrax threat needs aggressive government action plan, say researchers
5. Anthrax drugs used to treat adults can treat children, too
6. CDC MMWR: Fetal Alcohol Syndrome and Cutaneous Anthrax in a Lab Worker
7. Anthrax spores use failsafe protection system, say U-M scientists
8. Anthrax genome may contain new clues to fight infection, says Science Functional Genomics article
9. Anthrax dectectors are coming
10. Anthrax - Trail of terror
11. Anthrax - How to protect ourselves

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/2/2020)... ... 01, 2020 , ... AltruBio Inc. http://www.altrubio.com , a ... for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European Hematology Association ... of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase 1 single ...
(Date:7/1/2020)... ... 01, 2020 , ... Catalent, a global leader in clinical ... packaging facility in Minakuchi, located in the Shiga prefecture of Japan. , Operating ... the new 60,000-square-foot facility will provide customers with flexible clinical supply solutions, serving ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... software solutions for biopharmaceutical R&D, today announced that it has entered into ... full-length multispecific antibodies (Multiclonics®), to support their translational and clinical research strategy ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... , ... After research model surgery and catheter implantation, the long journey of ... beginning of a successful study, while protecting and accessing the catheter or device post-surgery ... Surgery from Envigo in a live webinar on Wednesday, August ...
(Date:7/18/2020)... ... July 16, 2020 , ... Medial EarlySign , ... and prevention of high-burden diseases, and Centric Consulting, a business and technology consulting ... utilize existing data in order to identify and prioritize patients for care. , ...
(Date:7/10/2020)... LORTON, Va. (PRWEB) , ... July 08, 2020 ... ... laboratory testing services and products, announces a significant expansion of laboratory operations through ... robust collection for agencies implementing testing programs. , Bode-CARES provides ...
(Date:7/10/2020)... ... July 09, 2020 , ... In most research using the ... pigment formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. Over ... been using the zebrafish model to investigate the causes of leukaemia and its ...
Breaking Biology Technology:
Cached News: