Anthrax research might provide more time for treatment

TROY, N.Y. Researchers at Rensselaer Polytechnic Institute in Troy, N.Y., have been awarded new federal grant money to develop experimental compounds that may someday extend the period during which a person exposed to anthrax can be treated successfully. Ravi Kane, assistant professor of chemical and biological engineering at Rensselaer has been awarded a grant of $500,000 from the National Institutes of Health's National Institute of Allergy and Infectious Diseases (NIAID) to develop inhibitors of the anthrax toxin. The inhibitors will be tested in collaboration with Dr. Jeremy Mogridge at the University of Toronto.

The potentially deadly disease anthrax is caused by a toxin secreted by the spore-forming bacterium Bacillus anthracis. Antibiotics can kill the bacteria and, started early enough, offer successful treatment in many cases. Standard antibiotic treatment has no effect on the amount of toxin that builds up in the blood over time, however, making speedy treatment crucial.

Standing in the Way of Infection

"An effective anthrax inhibitor would be able to prevent the toxin from binding to receptors on the human cell, thereby hindering the toxin from doing any damage," Kane said. Unlike antibiotics, which can kill the bacteria but do not affect the toxin, an inhibitor also would be able to reduce levels of toxin that have been released into the body. Once levels of toxin have been lowered, standard antibiotic treatment also would be administered to kill all remaining bacteria. "Combined with standard antibiotic treatment, a toxin inhibitor would enable the successful treatment of anthrax at later stages of the disease and allow many more lives to be saved," Kane said.

New Option for Prevention

Heightened awareness of the ability to deliver anthrax spores through the air, combined with the high mortality rate of the inhaled form of the disease, has led to the use of the spores as a biological weapon. An anthrax v

Contact: Joely Johnson
Rensselaer Polytechnic Institute

Page: 1 2

Related biology news :

1. Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design
2. Anthrax spores can germinate, grow and reproduce in soil
3. Anthrax: A soil bug gone bad
4. Anthrax threat needs aggressive government action plan, say researchers
5. Anthrax drugs used to treat adults can treat children, too
6. CDC MMWR: Fetal Alcohol Syndrome and Cutaneous Anthrax in a Lab Worker
7. Anthrax spores use failsafe protection system, say U-M scientists
8. Anthrax genome may contain new clues to fight infection, says Science Functional Genomics article
9. Anthrax dectectors are coming
10. Anthrax - Trail of terror
11. Anthrax - How to protect ourselves

Post Your Comments:

(Date:8/27/2019)... (PRWEB) , ... August 27, 2019 , ... ... company, announced today new opportunities to improve genetic testing guidelines. In the largest ... improve the guidelines to identify more at-risk patients. , Clinicians use guidelines ...
(Date:8/21/2019)... ... August 21, 2019 , ... ... cell line for rapid and low-cost biomanufacturing of complex protein therapeutics, today announced ... member of AbSci's Scientific Advisory Board, Dr. Larimore brings more than 30 years ...
(Date:8/15/2019)... ... 15, 2019 , ... Serialization deadlines in the US and ... and aggregation becomes fully applied in the United States in 2023, pharmaceutical companies ... Until now, most regulations?including the Drug Supply Chain Security Act (DSCSA)?have required minimal ...
Breaking Biology News(10 mins):
(Date:9/2/2019)... DENVILLE, N.J. and LIÉGE, Belgium (PRWEB) , ... ... ... provider of solutions for epigenetics research and in vitro diagnostics, has launched the ... to uncover the underlying biological meaning of epigenetic data and other data ...
(Date:8/29/2019)... (PRWEB) , ... August 29, 2019 , ... ... year to teach in the Sustainable Medicines in Africa program, which includes a ... take place in Arusha, Tanzania September 2nd through 13th, 2019. Topics to ...
(Date:8/25/2019)... , ... August 23, 2019 , ... ... No. 1 best-selling status for the scientific research book “Impact of Biofield Treatment ... cosmetic and perfume industry as Patchouli. , The book garnered No. 1 ...
(Date:8/15/2019)... ... August 15, 2019 , ... PathSensors announced today ... a member of the Institute of Food Technologists (IFT) Board of Directors, Illinois ... Joint Institute for Food Safety and Applied Nutrition (JIFSAN) Advisory Council and the ...
Breaking Biology Technology:
Cached News: