HOME >> BIOLOGY >> NEWS
Anti-cancer agent built from anti-inflammatory drug

COLUMBUS, Ohio Researchers have used a recently developed anti-inflammatory drug as a starting point to construct a possible new, targeted anti-cancer agent. The new agent works by triggering cancer cells to self-destruct.

The agent is now undergoing laboratory testing by the National Cancer Institute's (NCI) Rapid Access to Intervention Development (RAID) program.

The potential new drug was developed by researchers at The Ohio State University College of Pharmacy and the OSU Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. Presently, the agent is known as OSU-03012. The study is published in the June 15 issue of the journal Cancer Research.

"This new agent works by inhibiting a fundamental signaling point in cancer cells, making it potentially effective in a wide range of cancer types," says study leader Ching-Shih Chen, professor of pharmacy and a researcher with OSU's Comprehensive Cancer Center.

"We also have evidence that it may sensitize leukemia, and breast and lung cancers to conventional chemotherapy."

The new agent is based on the drug celecoxib, a nonsteroidal anti-inflammatory drug, or NSAID. Like many NSAIDs, celecoxib also reduces the risk of colorectal cancer when taken regularly.

Scientists knew from the start that celecoxib helps control inflammation by inhibiting an enzyme known as cyclooxygenase-2 (COX-2). But they couldn't explain the drug's modest anti-cancer activity.

Past work led by Chen provided the answer.

"We found that celecoxib's ability to cause cell death and to control inflammation were two different pharmacological properties, and that the two properties could be separated," Chen says. This work was published in the Journal of the National Cancer Institute.

Chen and his colleagues then showed that celecoxib inhibited a molecule known as Akt.

Chen describes Akt as an important molecular switch that
'"/>

Contact: Darrell E. Ward
Ward-15@medctr.osu.edu
614-293-3737
Ohio State University
7-Jul-2004


Page: 1 2

Related biology news :

1. Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
2. Anti-cancer compound could cause serious liver damage, report University of Pittsburgh scientists
3. Light turns on anticancer agents
4. Managing occupational exposures to potential bioterrorist agents
5. Proteomic research centers target bioterrorism agents, infectious diseases
6. Device that rapidly detects nerve agents named one of greatest army inventions for 2003
7. When combining new oral anti-cancer agents with standard chemotherapy, timing may be crucial
8. Chicken litter harbors agents that generate antibiotic multi-resistance, according to UGA study
9. Enlisting carbon nanotubes to unmask nerve agents
10. New device can help defend against novel biological agents
11. American Society for Microbiology publication provides guidance for shipping biological agents

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 24, 2020 , ... ... chronic inflammatory and fibrotic diseases, today announced that Dr. Stacie Canan has joined ... , Dr. Canan previously served as Executive Director of Global Health at Bristol ...
(Date:8/26/2020)... ... ... Modality Solutions, a biopharmaceutical cold chain validation engineering firm, is ... is the most prestigious ranking of the nation’s fastest-growing private companies. Modality Solutions made ... three-year revenue growth of 71 percent. , The Inc. 5000 list represents a ...
(Date:8/21/2020)... ... August 19, 2020 , ... “How can we ... dedicated to Salivary Bioscience for more than twenty years. Together with Douglas Granger, ... " Salivary Bioscience: Foundations of Interdisciplinary Saliva Research and Applications ," and Steven ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 12, 2020 , ... Inc. ... a global leader in FDA compliance consulting has been named on its annual ... The list represents a unique look at the most successful companies within the ...
(Date:8/3/2020)... ... August 03, 2020 , ... Introducing Ardent Animal Health – ... , Known as MediVet Biologics since its formation in 2016, ... The new Ardent Animal Health will build on its base of innovative therapies for ...
(Date:7/31/2020)... ... 29, 2020 , ... Diversified Technologies, Inc. has introduced a ... to drive Klystrons, TWTs, IOTs, and magnetrons. , DTI Radar Transmitter Systems ... a push-pull configuration; yielding fast fall time for a capacitive load. These all ...
(Date:7/31/2020)... , ... July 29, 2020 , ... eSource has long ... This webinar will cover the history of eSource, the reasons it did not take ... to wearables, to site source, the industry is moving towards capturing data electronically for ...
Breaking Biology Technology:
Cached News: