HOME >> BIOLOGY >> NEWS
Anti-interferon beta antibodies in MS care: A consensus

which reduce the frequency and severity of MS relapses or attacks, reduce brain lesion development and generally delay future disability. Few options for treating MS existed until these biologic therapies became available. However, some MS patients taking an interferon beta (Avonex, Betaseron or Rebif) develop neutralizing antibodies (NAbs), which limit or prevent the medication from having its full therapeutic effect. As treatment with biologics increases, physicians and patients need expert guidance regarding this issue.

In November 2003, a CMSC consensus statement on how biologics affect NAbs was published in Neurology. The consensus was the result of an extensive review of studies by over 33 immunologists and neurologists. The CMSC sought to answer the following questions:

  • What is currently known about anti-interferon beta antibodies and their effects on patients with MS treated with interferons?
  • Do all interferon betas result in comparable levels of NAbs?
  • What are the tests available to detect antibodies; how accurate are they; and what is the best method for their detection in clinical care?
  • What are the research priorities in advancing our knowledge of this field?

    Current and Future Strategies

    The CMSC recommends that a laboratory test for NAbs be performed routinely with other standardized tests at least one and two years after start of treatment. Additionally, the CMSC counsels patients and their doctors to consider NAbs when selecting a long-term treatment for MS. Based on prescribing information, NAbs have been detected at different levels among the available interferon betas:

  • 43% of Betaseron patients (Interferon Beta-1b)
  • 24% of Rebif patients (Interferon Beta-1a)
  • 5% of Avonex patients (Interferon Beta-1a)

    "Therefore, it is incumbent on both physicians and their patients to understand the potential effects of NAbs on the long-term treatmen
    '"/>



  • Contact: Cindy Gessell
    cindy.gessell@ketchum.com
    201-652-4778
    Ketchum
    14-Feb-2004


    Page: 1 2 3

    Related biology news :

    1. Researchers find clues about how antibodies specialize
    2. Second generation targeted antibodies - Its all in the binding
    3. Researchers show autoantibodies occur before lupus in New England Journal of Medicine
    4. Programmable antibodies-- hybrid cancer therapy described by scientists at Scripps
    5. Bodys own antibodies may drive new strains of HIV
    6. Growing human antibodies in algae
    7. Blasting antibodies with lasers provides direct way of measuring their flexibilities
    8. Ozone produced by antibodies during bacterial killing and in inflammation
    9. Artificial antibodies created by new molecular imprinting process
    10. Human antibodies against spores found by researchers suggest new tool to detect and treat anthrax
    11. Scientists at The Scripps Research Institute discover a previously unknown role for antibodies

    Post Your Comments:
    *Name:
    *Comment:
    *Email:


    (Date:8/12/2020)... ... 11, 2020 , ... Both Roche, based in Basel, Switzerland, ... agreements with Housey Pharma’s HMI subsidiary to gain access to its core-enabling technology ... and Development spending in excess of US $10 billion. , Scientists at Housey ...
    (Date:8/7/2020)... ... 2020 , ... Alucio™, a fast-growing provider of cloud-based software ... Jessica Wong have joined the company’s leadership team as Vice President of Engineering, ... development efforts for Alucio’s flagship product, Beacon, an innovative cloud-based content management and ...
    (Date:8/5/2020)... ... August 05, 2020 , ... Regenative Labs has received approval ... CoreText™ and ProText™, making them the first Wharton’s jelly allografts to be assigned a ... The company’s solutions are the first Wharton’s jelly allograft product to be recognized as ...
    Breaking Biology News(10 mins):
    (Date:7/18/2020)... ... July 16, 2020 , ... “We are thrilled to deliver this new technology ... technology of its kind on the market and we were pleased that the IFT ... of traditional cultured ingredients, creating a natural way to extend the shelf life and ...
    (Date:7/10/2020)... ... July 09, 2020 , ... ... Massachusetts Institute of Technology (MIT) has expanded the company’s exclusive license to ... move into the point-of-care diagnostic market, focusing initially on the SARS-CoV-2 biosensor. ...
    (Date:7/7/2020)... ... , ... Bio-IT World has announced the winners of the ... of Chicago, Massachusetts General Hospital, Mission: Cure, and the Pistoia Alliance were honored. ... examples of how technology innovations and strategic initiatives can be powerful forces for ...
    (Date:6/28/2020)... ... June 25, 2020 , ... The Indoor Lab, a leading ... Space™ for businesses of all types to ensure cleanliness, distancing and occupancy with its ... A Safe Space™ enabled business will provide a health performance index system that scores ...
    Breaking Biology Technology:
    Cached News: