Anti-malarial assistant

Creating an effective vaccine against an infectious disease is not as simple as activating an immune response. Immune activation can take many forms, not all of which are effective against all pathogens. An adaptive immune response involving cytotoxic T cells (CTL) has been demonstrated to be necessary to effectively prevent malaria, which is caused by the parasite Plasmodium falciparum in humans. Thus a vaccine that results in CTL activation could presumably be effective in protecting against malarial infection. To generate an effective adaptive immune response, a specific antigen is injected along with an adjuvant (traditionally a crude extract that promotes an immune response). Although protective antigens have been defined, a problem in formulating an effective malarial vaccine is that it is difficult to get the immune system to respond by generating long-lasting CTLs in sufficient numbers to these antigens.

In the March 4 issue of The Journal of Experimental Medicine, Moriya Tsuji and colleagues demonstrate that a glycolipid (a-GalCer) originally isolated from marine sponges can serve just such a purpose act as a CTL promoting adjuvant against malaria when used in conjunction with Plasmodium vaccines. a-GalCer interacts with a receptor on a specialized lymphocyte (NKT cell) that bridges two arms of the immune system, innate and adaptive immunity. By co-injecting a-GalCer with various malaria vaccines, such as irradiated sporozoites and recombinant adenoviruses, Tsuji and colleagues were able to enhance long-lasting CTL mediated immunity against a mouse model of malaria infection. The authors discuss how this adjuvant may be an effective tool in generating vaccines against a variety of intracellular microbial pathogens including HIV.


Contact: Lynette Henry
Journal of Experimental Medicine

Page: 1

Related biology news :

1. E-BioSci: Europes gateway to the life sciences
2. Cannabis may help combat cancer-causing herpes viruses
3. Scientists find nanowires capable of detecting individual viruses
4. $7.5 Million grant to Yale researchers for role of viruses in cancer
5. Defensive action by influenza viruses demonstrated by Hebrew university researcher
6. Bright idea could doom cancer and viruses, say Purdue scientists
7. Measuring artificial viruses to improve disease detection
8. Study suggests double punch could more efficiently kill viruses
9. Mite transmits viruses damaging to wheat
10. A new way to kill cancer: SLU research shows viruses can destroy lung, colon tumors
11. Gene with key role in replicating pox viruses also halts inflammation

Post Your Comments:

(Date:7/10/2020)... Va. (PRWEB) , ... July 08, 2020 , ... ... Latest on Cell and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July 22, ... need a comparability study, but what is the most effective way to complete ...
(Date:7/2/2020)... ... July 02, 2020 , ... ... announced a publication detailing the use of its revolutionary NEXTGENPCR endpoint thermocycler ... (RT-PCR) in 16 minutes. The article, titled "Ultra-fast one-step RT-PCR protocol for ...
(Date:6/28/2020)... ... June 25, 2020 , ... In an upcoming episode scheduled ... accelerated Point of Care Testing solutions (POCT). Check local listings for more info. , ... medical offices and are shipped to labs throughout the country. Results are then available ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 30, 2020 , ... ... life sciences industry, today announced the release of its signature product called ... Science Liaisons (MSLs) and other field medical professionals. , Beacon helps ...
(Date:7/18/2020)... ... 16, 2020 , ... “We are thrilled to deliver this new technology to ... of its kind on the market and we were pleased that the IFT jury ... traditional cultured ingredients, creating a natural way to extend the shelf life and improve ...
(Date:7/10/2020)... LORTON, Va. (PRWEB) , ... July 08, 2020 ... ... laboratory testing services and products, announces a significant expansion of laboratory operations through ... robust collection for agencies implementing testing programs. , Bode-CARES provides ...
(Date:7/10/2020)... ... July 09, 2020 , ... Sentien Biotechnologies, Inc., a clinical-stage ... Allen R. Nissenson, M.D., F.A.C.P., as its Chief Medical Officer. Dr. Nissenson ... product, SBI-101. Dr. Nissenson serves as an Emeritus Professor of Medicine at ...
Breaking Biology Technology:
Cached News: