HOME >> BIOLOGY >> NEWS
Antibiotics-resistant bacteria

REHOVOT, Israel -- July 1, 1999 -- DNA becomes remarkably organized in bacteria that are subjected to various conditions of stress, Weizmann Institute scientists report in the July 1 issue of Nature. The tightly packed configuration of the DNA promotes the ability of the cells to withstand extreme environmental assaults such as oxidative agents and starvation.

This finding may one day allow the development of more efficient methods to fight bacterial diseases. In addition, if a link is found between the mechanisms allowing bacteria to survive under stress, and those that render bacteria resistant to various chemical agents, chemotherapy could be efficiently used against pathological bacteria which have become resistant to other types of antibiotics.

The Weizmann team, headed by Prof. Avi Minsky of the Organic Chemistry Department, discovered that bacterial DNA forms a crystalline organization when bacteria are exposed to harsh conditions. They further revealed that this highly ordered structure is formed by the mediation of a protein called Dps which strongly binds to DNA. The Dps protein, initially characterized by the group of Prof. Roberto Kolter at Harvard Medical School with which Prof. Minsky collaborates, is present at high levels in stressed cells. Within the ordered and tightly packed DNA-Dps structure, the DNA is very effectively protected against various assaults.

"In natural environments, bacterial life alternates between short periods of feast and long periods of famine and stress," Prof. Minsky said. "In order to survive, bacteria have evolved sophisticated mechanisms that allow them to protect themselves during starvation and stress, as well as to very rapidly resume growth when nutrients are again available. The ordered DNA structure may represent the ultimate mode of protection."

The scientists used X-ray and electron microscopy techniques to investigate the molecular structure of the complex made from the Dps protein and the D
'"/>

Contact: Jeffrey J. Sussman
Jeffrey@acwis.org
212-779-2500
American Committee for the Weizmann Institute of Science
1-Jul-1999


Page: 1 2

Related biology news :

1. Researchers find color sensitive atomic switch in bacteria
2. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
3. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
4. Scientists discover potential new way to control drug-resistant bacteria
5. 22nd amino acid synthesized and added to genetic code of e. coli bacteria
6. Missing genes may help explain why plague bacteria are so deadly
7. Complex cells likely arose from combination of bacterial and extreme-microbe genomes
8. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
9. UC Irvine scientists to develop vaccine to combat bioterrorism threat from deadly bacteria
10. UV light, coatings reduce bacterial adhesion up to 50 percent
11. PCB breakdown in rivers depends on sediment-specific bacteria, find Carnegie Mellon U. scientists

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2020)... ... August 18, 2020 , ... Sentien Biotechnologies, Inc., a clinical-stage ... Food and Drug Administration (FDA) has approved the company’s Investigational New Drug (IND) ... severe COVID-19. Approval of this IND allows Sentien to initiate a Phase 1/2 ...
(Date:8/12/2020)... SOUTHFIELD, Mich. (PRWEB) , ... August 11, 2020 ... ... Janssen R&D subsidiary based in Princeton, NJ, have entered into license agreements with ... discovery and development. Both Roche and J&J have annual Research and Development ...
(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
Breaking Biology News(10 mins):
(Date:7/22/2020)... ... July 22, 2020 , ... Join experts from Reed Tech , Gary ... in a one hour live webinar on Thursday, August 13, 2020 at ... drugs and medical devices. Specifically, for medical devices, the NMPA has departments dealing with ...
(Date:7/10/2020)... ... July 08, 2020 , ... ... announces a significant expansion of laboratory operations through its COVID-19 testing service, ... testing programs. , Bode-CARES provides a turnkey solution that includes ...
(Date:7/7/2020)... (PRWEB) , ... July 06, 2020 , ... ... Practices Awards. Entries from Roche, Eli Lilly, Bristol-Myers Squibb, the University of Chicago, ... 2003, Bio-IT World has hosted an elite awards program, highlighting outstanding examples of ...
(Date:6/28/2020)... ... June 25, 2020 , ... With the ... vaccine or drug treatment. In an effort to better understand the cellular responses ... world’s largest imaging dataset portraying therapeutic compound effects from over 1,600 approved and ...
Breaking Biology Technology:
Cached News: