HOME >> BIOLOGY >> NEWS
Anticancer drug zebularine specifically targets tumor cells

LOS ANGELES, August 23, 2004 A novel anticancer drug that inhibits a process known as DNA methylation is preferentially taken up by tumor cells as compared to normal cells, according to a group of researchers led by scientists from the Keck School of Medicine of the University of Southern California.

In addition, this drug--a methylation inhibitor called zebularine--is better at inhibiting cell growth and promoting gene expression in cancer cells, notes Peter Jones, Ph.D., director of the USC/Norris Comprehensive Cancer Center and the principal investigator on the study. In a study of zebularine's effect on the rate of division of cancer cells, Jones and colleagues showed that zebularine slows growth by as much as 68 percent in cancer cells, but only by 21 percent or less in normal cells.

These findings were reported in the August 2004 issue of Cancer Cell.

Only recently have scientists begun to recognize the important role that DNA methylation--the addition of a methyl group to a stretch of DNA, which can lock, or silence, that gene--can play in the development of cancer. If methylation silences a gene that normally would control cell growth or prompt the cell to commit suicide, then the cell will grow unchecked--the hallmark of cancer.

The good news: Methylation--and its effects--can be reversible. Enter the emerging field of epigenetic therapy, in which methylation inhibitors are currently playing a starring role.

"The concept that the silencing of genes is a critical part of the cancer process is a major conceptual advance in this field," Jones says. "Realizing that, it becomes very important to find keys to unlock those silenced genes."

In the Cancer Cell study, Jones, Cheng and graduate student Christine Yoo--along with colleagues from the National Cancer Institute, the University of Miami School of Medicine, and Aarhus University Hospital in Denmark--looked at the effects zebularine had on a panel of sev
'"/>

Contact: Sarah Huoh
shuoh@usc.edu
323-442-2830
University of Southern California
23-Aug-2004


Page: 1 2 3

Related biology news :

1. Anticancer drug reveals alternate means of inducing cell suicide
2. The Bodys Anticancer Weaponry Backfires In Old Age
3. Enzymes "Magic" May Hold Key to Anticancer and Antimicrobial Drugs
4. Some carotenoids specifically target colon cancer
5. Images of tail of protein needed for cell multiplication suggest anticancer drug targets
6. Study suggests cell-cycle triggers might be cancer drug targets
7. Stem cell research targets cerebral palsy
8. Energy conservation targets hit by notions of comfort
9. Yale researchers discover new potential asthma therapeutic targets related to parasites and insects
10. Researchers identify two potential protein targets for new drug therapies for pancreatic cancer
11. Moving targets: when it comes to patterns, motion gets factored in

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/6/2019)... ... August 06, 2019 , ... ... concerns. One plant-based food in particular quickly entered the limelight – meat alternatives. ... use a thermogelling and emulsifying ingredient such as methyl cellulose. This ingredient is ...
(Date:8/1/2019)... , ... August 01, 2019 , ... The GENSPEED platform ... of care. It is fully developed with over 100 units deployed in the ... new fields of use, our collaboration with axiVEND will give us a foothold in ...
(Date:8/1/2019)... ... July 31, 2019 , ... Molecular Devices, LLC, a leader ... generation of its FLIPR® Penta High-Throughput Cellular Screening System. , The new FLIPR ... of G-protein-coupled receptors (GPCRs) and ion channels, offering a new high-speed camera option ...
Breaking Biology News(10 mins):
(Date:7/26/2019)... ... July 25, 2019 , ... ... collaboration and dialogue, today announces its Boston BD conference to be ... of Biotech Week Boston , the event provides an opportunity for attendees ...
(Date:7/17/2019)... ... July 16, 2019 , ... ... and manufacturing of Zolgensma® (onasemnogene abeparvovec-xioi), an AveXis gene therapy treatment for ... will have dedicated manufacturing space at the new, state-of-the-art commercial manufacturing center ...
(Date:7/2/2019)... ... July 02, 2019 , ... Leading Regenerative Veterinary Medicine company, VetStem Biopharma ... Biotech. The film focuses on regenerative veterinary medicine as a means of improving ... recently included in the Brentwood and Pacific Palisades International Film Festival in Los ...
(Date:6/11/2019)... ... June 10, 2019 , ... ... network with the appointment of Biofeedback Tech Ltd as its authorised ... an essential part of many therapeutic treatments and clinical assessment protocols to treat ...
Breaking Biology Technology:
Cached News: