HOME >> BIOLOGY >> NEWS
Antimalarial substances found in New Caledonian sponges

Marine organisms synthesize many different substances, some of which possess anticarcinogenic, antiviral or antiparasitic properties. Only 1% of recorded marine species have had their chemical composition analysed. IRD scientists and their partners (1) have investigated the chemical structure of substances extracted from New Caledonian sponges. They demonstrated antimalarial activity in 25 members of the phloeodictine family of alkaloids, isolated from one of the species of shallow-water sponge present in lagoon. Laboratory tests showed these substances to be active against a chloroquine-resistant strain of Plasmodium falciparum, the pathological agent of malaria. These substances with hitherto unknown structures have potential as starting material for elaborating novel antimalarial medicines. Living organisms are an enormous reservoir of natural compounds potentially active against viruses, bacteria or cancerous cells, that could lead to the development of new medicines. Out of about 145 000 natural substances described today, 10% come from marine organisms. Among the few such organisms studied for their chemical composition, sponges of the genus Phloeodictyon (Haploscleridae) collected in shallow New Caledonian waters during campaigns of the programme "Marine Substances of Biological Interest" (SMIB), have proved to contain particular organic compounds, the phloeodictines, alkaloids with powerful antibacterial properties (2). Up to now, only deep-water species of Phloeodictyon were thought to synthesize these alkaloids, present in all the samples of such bathyal forms taken from an array of seamounts off the southern sector of New Caledonia. However, phloeodictines have recently been found in shallow-water Oceanapia (a taxonomic synonym of Phloeodictyon) species living on the reef off the east coast of New Caledonia, by a joint scientific team involving the IRD, the University of Trente (Italy), the CNRS and the industrial group Pierre
'"/>

Contact: Bndicte Robert
presse@paris.ird.fr
33-148-037-519
Institut de Recherche Pour le Dveloppement
21-Jul-2004


Page: 1 2 3

Related biology news :

1. Antimalarial drug may point way to new class of antibiotics
2. SCOPE/IUPAC report on endocrine active substances to be published
3. IUPAC report- Natural and synthetic substances
4. Stratified seawater disrupts the transport of imposex substances
5. Fred Hutchinson Cancer Research Center, University of Washington join in national effort to study health impact of toxic substances
6. Federal government makes final call for data, public comment before writing new report on cancer-causing substances
7. Wood dust, talc, estrogens, and nickel alloys among substances being reviewed for inclusion in Report on Carcinogens
8. List of MAK and BAT values 1999 published - New classification for chemical substances in the workplace air
9. New signs of life found at the Poles
10. Key cell-death step found
11. European common frog found to use novel mating strategy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2019)... ... 15, 2019 , ... Serialization deadlines in the US and ... and aggregation becomes fully applied in the United States in 2023, pharmaceutical companies ... Until now, most regulations?including the Drug Supply Chain Security Act (DSCSA)?have required minimal ...
(Date:8/14/2019)... ... 2019 , ... Representatives with MyBioGate announced that China Focus@Biotech Week will be ... help innovative projects connect with Chinese pharma and investors in healthcare innovation,” said Miao ... explain that as a part of Biotech Week Boston – the annual biotech festival ...
(Date:8/6/2019)... ... August 06, 2019 , ... A ... system that could have far-reaching implications for personalized medicine, especially when seeking treatments ... is able to predict which stem cell donors and manipulation methods might yield ...
Breaking Biology News(10 mins):
(Date:7/17/2019)... ... July 16, 2019 , ... ... recent report from Kalorama Information. Abbott, Roche and Siemens Healthineers and Response Biomedical ... latest report, Worldwide Market for Point-of-Care (POC) Diagnostics . , Quidel is ...
(Date:7/2/2019)... ... July 02, 2019 , ... Leading Regenerative Veterinary Medicine company, ... Where Beasts Meet Biotech. The film focuses on regenerative veterinary medicine as a ... Pharm was recently included in the Brentwood and Pacific Palisades International Film ...
(Date:6/12/2019)... N.J. (PRWEB) , ... June 12, 2019 , ... ... custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device and ... Shanghai Zillion has been signed. The agreement will grant exclusive rights for Zillion ...
(Date:6/11/2019)... ... June 11, 2019 , ... Mytonomy, the ... national leader in opioid treatment, announced today they are partnering to combat the ... recently deployed its virtual care platform at the Mayo Clinic to drive shared ...
Breaking Biology Technology:
Cached News: