HOME >> BIOLOGY >> NEWS
Antimalarial substances found in New Caledonian sponges

Fabre. This discovery suggests a possible adaptation of bathyal species to the shallow-water reef environment.

The emergence of drug-resistant forms of the malarial agent Plasmodium falciparum has made essential a search for new compounds to control it. Scientists specialized in natural substances, investigating the chemical structure and properties of the phloeodictines as part of the French malaria control research programme Pal +, have revealed antimalarial activity among phloeodictines extracted from the reef sponge Oceanapia fistulosa.

The phloeodictines are a family of alkaloids, composed of three large groups distinguished according to differences in their chemical skeleton. They all carry a lateral poly-N chain and a variable-length carbon chain (3). Phloeodictines types B and C, which are minority compounds, carry an additional sulfurated poly-N chain. Smaller structural variations can occur in each of these three groups, in the lateral chains of variable length and degree of unsaturation, This makes for a highly complex chemical family. A combination of chromatographic and spectrometric methods obtained the characterization of 25 different compounds that belong to these three groups, extracted from Oceanapia fistulosa. Seventeen of them are new variants.

Laboratory tests involving presentation of a chloroquine-resistant strain of Plasmodium falciparum with these different components demonstrated low-dose inhibition of parasite development by type A phloeodictines, most of which were new.

A particularly promising feature of these phloeodictines' antimalarial action is that, in vitro, it is accompanied by very low cytotoxicity. These components therefore hold potential as material for the elaboration of antimalarial medicines with new types of structure. Other investigations are planned to seek confirmation of these results and find out accurate information on this antimalarial activity in vivo, using infected rodent
'"/>

Contact: Bndicte Robert
presse@paris.ird.fr
33-148-037-519
Institut de Recherche Pour le Dveloppement
21-Jul-2004


Page: 1 2 3

Related biology news :

1. Antimalarial drug may point way to new class of antibiotics
2. SCOPE/IUPAC report on endocrine active substances to be published
3. IUPAC report- Natural and synthetic substances
4. Stratified seawater disrupts the transport of imposex substances
5. Fred Hutchinson Cancer Research Center, University of Washington join in national effort to study health impact of toxic substances
6. Federal government makes final call for data, public comment before writing new report on cancer-causing substances
7. Wood dust, talc, estrogens, and nickel alloys among substances being reviewed for inclusion in Report on Carcinogens
8. List of MAK and BAT values 1999 published - New classification for chemical substances in the workplace air
9. New signs of life found at the Poles
10. Key cell-death step found
11. European common frog found to use novel mating strategy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... LAKE CITY, and MARTINSRIED, Germany (PRWEB) , ... ... ... in high-throughput antibody screening and characterization, announced today that they have opened a ... Carterra’s platform has fueled the need for the new office. , The Munich ...
(Date:8/14/2019)... JOLLA, Calif. (PRWEB) , ... August 14, 2019 , ... ... insight into their future children, announces inclusion in the 38th annual Inc. 500|5000 ... been eligible to apply. To qualify, companies must have been founded and generating revenue ...
(Date:8/9/2019)... ... August 09, 2019 , ... With a demand in healthcare to ... patients will visit urgent care centers (UCC) in the coming years, according to a ... The Market for Urgent Care Centers , is a detailed look at the current ...
Breaking Biology News(10 mins):
(Date:8/14/2019)... ... August 13, 2019 , ... ... on prepackaged mobile phases for QC laboratories. After gaining a few significant clients, ... sciences approach into a valued supplier of manufacturing processing solutions, including reagents for ...
(Date:8/6/2019)... ... August 06, 2019 , ... ... characterizing microbiome populations down to the strain level, has announced partnerships with six ... other products to companies and research organizations in Australia, Benelux, Indonesia, Korea, Malaysia, ...
(Date:7/30/2019)... SAN DIEGO (PRWEB) , ... July 30, 2019 ... ... Lajollacooks4u, San Diego’s premiere team building and cooking events company. Not only has ... but it has also started offering Private Cooking Parties to its guests. , ...
(Date:7/19/2019)... NEWPORT BEACH, Calif. (PRWEB) , ... July 18, ... ... who is also known as “Ravi Everest,” will be joining forces with California-based ... to be held from July 20-22nd. Coalition Duchenne raises awareness and funding for ...
Breaking Biology Technology:
Cached News: