HOME >> BIOLOGY >> NEWS
Antioxidant Action Of Vitamin E Significantly Reduces Heart Disease In Mice

In mice genetically manipulated to develop atherosclerosis, scientists at the University of Pennsylvania Medical Center have for the first time conclusively demonstrated that vitamin E confers potent protection from the disease. Atherosclerotic damage to cardiovascular tissues was limited by about 40 percent in at-risk mice receiving doses of the vitamin for only 16 weeks.

The researchers were also able to show that the benefit was due to the antioxidant action of vitamin E, not to other possible effects such as a reduction in blood cholesterol levels. This fact strongly suggests that free radicals do, in fact, play a central role in heart disease, a theory long proposed but never proven. A novel method recently developed by the same group for directly measuring oxidant stress in the body provided the data in support of the observations.

A report on the new findings appears in the October issue of Nature Medicine.

"This study offers powerful evidence for the efficacy of vitamin E as an antioxidant in atherosclerosis," says Garret A FitzGerald, MD, chairman of the department pharmacology and senior author on the report. "Significantly, it also shows that free-radical injury is functionally important in the development of cardiovascular disease."

The innovative measurement technique used in the study was developed in FitzGerald's laboratory in collaboration with Joshua Rokach, PhD, a chemist at the Florida Institute of Technology. It assesses the levels in blood or urine of certain biochemicals called isoprostanes. These isoprostanes are stable byproducts of free-radical catalyzed damage to lipids, or fatty molecules, found in tissues throughout the body, and they serve as quantitative markers for that damage.

The strain of mice used in the experiments has been genetically engineered to lack the apoE gene, resulting in extremely high levels of cholesterol and triglycerides in their blood. Atherosclerot
'"/>

Contact: Franklin Hoke
hokef@mail.med.upenn.edu
(215) 349-5659
University of Pennsylvania School of Medicine
29-Sep-1998


Page: 1 2 3

Related biology news :

1. Antioxidants during pregnancy may help prevent birth defects tied to alcohol
2. Antioxidant protects islet cells used in transplants for diabetes
3. Antioxidant vitamins may help transplant patients
4. Antioxidant prevents type 1 diabetes in mice
5. AHA Says Scientific Evidence Does Not Yet Support Recommending Vitamin E Or Other Antioxidant Supplements
6. Supplementing Diet With Fruits And Vegetables, Rather Than Vitamins, Provides Needed "Antioxidants"
7. Antioxidant Treatment Holds Promise For Combating Malnourishment
8. In New Alzheimers Studies, Lab Tests Show Vitamin E And Other Antioxidants Preventing Brain Cell Death
9. Antioxidant Vitamin Supplementation And Lipid Peroxidation In Smokers
10. Antioxidants May Reduce Harmful Complications Of Diabetes
11. Diet, Antioxidant Status, And Smoking Habits In French Men

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/27/2019)... ... April 26, 2019 , ... ... Assessment Report: The Laboratory Analytical & Life Science Instrumentation Industry ," provides ... that include chromatography, life science instrumentation, mass spectrometry, molecular spectroscopy, atomic spectroscopy, ...
(Date:4/25/2019)... ... , ... NDA Partners Chairman Carl Peck, MD , announced today that ... development of drug and genomic diagnostic products for therapeutic indications in oncology, has joined ... Maddala served as Vice President of Biometrics at GRAIL, Inc., where she built and ...
(Date:4/18/2019)... GUILFORD, Conn. and WALNUT CREEK, Calif. (PRWEB) , ... ... ... services cost management solution for the healthcare industry, today announced the launch of ... natural language processing to extract deep knowledge of Medpricer customers’ supplier contracts, truly ...
Breaking Biology News(10 mins):
(Date:4/8/2019)... ... April 08, 2019 , ... ... solutions, announced today the launch of their app integration solution, CT Cloud Unite. ... and contact-orientated applications while using CT Cloud Voice and Skype for Business solutions. ...
(Date:4/4/2019)... (PRWEB) , ... April 02, 2019 , ... ... PCR solutions, announced it would be releasing it’s latest field-ready solution for performing ... name Biomeme’s next-gen thermocycler Franklin™ pays homage to Rosland Franklin, an English chemist ...
(Date:3/27/2019)... ... March 26, 2019 , ... A leader in the field of ... veterinarians across the United States and Canada since 2004. The primary indications for ... injuries in the dog, cat, and horse. Recently, VetStem teamed up with ...
(Date:3/23/2019)... , ... March 22, 2019 , ... ... collection, and analysis to a team of researchers at Nnamdi Azikiwe University in ... Dr. Nneka R. Agbokoba, PhD, of the Department of Medical Laboratory Sciences and ...
Breaking Biology Technology:
Cached News: