HOME >> BIOLOGY >> NEWS
Antioxidant Action Of Vitamin E Significantly Reduces Heart Disease In Mice

In mice genetically manipulated to develop atherosclerosis, scientists at the University of Pennsylvania Medical Center have for the first time conclusively demonstrated that vitamin E confers potent protection from the disease. Atherosclerotic damage to cardiovascular tissues was limited by about 40 percent in at-risk mice receiving doses of the vitamin for only 16 weeks.

The researchers were also able to show that the benefit was due to the antioxidant action of vitamin E, not to other possible effects such as a reduction in blood cholesterol levels. This fact strongly suggests that free radicals do, in fact, play a central role in heart disease, a theory long proposed but never proven. A novel method recently developed by the same group for directly measuring oxidant stress in the body provided the data in support of the observations.

A report on the new findings appears in the October issue of Nature Medicine.

"This study offers powerful evidence for the efficacy of vitamin E as an antioxidant in atherosclerosis," says Garret A FitzGerald, MD, chairman of the department pharmacology and senior author on the report. "Significantly, it also shows that free-radical injury is functionally important in the development of cardiovascular disease."

The innovative measurement technique used in the study was developed in FitzGerald's laboratory in collaboration with Joshua Rokach, PhD, a chemist at the Florida Institute of Technology. It assesses the levels in blood or urine of certain biochemicals called isoprostanes. These isoprostanes are stable byproducts of free-radical catalyzed damage to lipids, or fatty molecules, found in tissues throughout the body, and they serve as quantitative markers for that damage.

The strain of mice used in the experiments has been genetically engineered to lack the apoE gene, resulting in extremely high levels of cholesterol and triglycerides in their blood. Atherosclerot
'"/>

Contact: Franklin Hoke
hokef@mail.med.upenn.edu
(215) 349-5659
University of Pennsylvania School of Medicine
29-Sep-1998


Page: 1 2 3

Related biology news :

1. Antioxidants during pregnancy may help prevent birth defects tied to alcohol
2. Antioxidant protects islet cells used in transplants for diabetes
3. Antioxidant vitamins may help transplant patients
4. Antioxidant prevents type 1 diabetes in mice
5. AHA Says Scientific Evidence Does Not Yet Support Recommending Vitamin E Or Other Antioxidant Supplements
6. Supplementing Diet With Fruits And Vegetables, Rather Than Vitamins, Provides Needed "Antioxidants"
7. Antioxidant Treatment Holds Promise For Combating Malnourishment
8. In New Alzheimers Studies, Lab Tests Show Vitamin E And Other Antioxidants Preventing Brain Cell Death
9. Antioxidant Vitamin Supplementation And Lipid Peroxidation In Smokers
10. Antioxidants May Reduce Harmful Complications Of Diabetes
11. Diet, Antioxidant Status, And Smoking Habits In French Men

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio ... findings of Neihulizumab, a biologic for the treatment of steroid-refractory acute graft-versus-host disease ... hemato-oncologist Dr. Paul J Martin of the Fred Hutchinson Cancer Research Center, this ...
(Date:7/1/2020)... (PRWEB) , ... July 01, 2020 , ... ... that it had completed the purchase of Teva-Takeda Pharmaceuticals’ packaging facility in Minakuchi, ... company’s existing Japanese clinical supply facility located in Kakegawa, the new 60,000-square-foot facility ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... biopharmaceutical R&D, today announced that it has entered into a multi-year contract ... (Multiclonics®), to support their translational and clinical research strategy to discover and ...
Breaking Biology News(10 mins):
(Date:6/23/2020)... (PRWEB) , ... June 23, 2020 , ... ... solutions in complex indoor environments, announced today that Derek Fournier has been appointed ... of Chairman of the Board, effective immediately. , “DeCurtis Corporation has been ...
(Date:6/23/2020)... NEW YORK (PRWEB) , ... June 22, 2020 ... ... profiling its lead glutamine antagonist, DRP-104, will be presented June 22-24 during the ... anti-cancer effects of DRP-104; and, the other profiles the potent, consistent single agent ...
(Date:6/19/2020)... ... , ... The Vitaspace project was founded by the famous Russian ... life and find a way (medicine or technology) that will help to preserve youth, ... scientists from all over the world, doctors, and all people who care. , The ...
(Date:6/11/2020)... , ... June 09, 2020 , ... ... Phase I of a Small Business Innovation Research (SBIR) program funded by the ... Century: Rapid Toxin Detection in the Field”. The project’s goal was to engineer ...
Breaking Biology Technology:
Cached News: