HOME >> BIOLOGY >> NEWS
Are we mice or men? Gene mutation linked to improving heart failure in mice proves lethal in humans

ardiac hypertrophy in which mice destined to develop cardiac hypertrophy were also genetically modified to lack the PLN gene. They found that the absence of the PLN gene restored impaired calcium signaling and muscle contraction in individual heart cells, however there was no reversal or prevention of hypertrophy of the whole heart.

In the second study, the authors found that individuals with naturally occurring mutations in the human PLN gene develop heart failure. Individuals that lacked the PLN gene suffered fatal heart failure. The results indicate that PLN is essential for cardiac health in humans and its absence is lethal the direct opposite of the results observed in mice.

In contrast to earlier successful studies in mice in which genetic manipulation was able to prevent or reverse heart failure, "these two studies provide a sobering reminder of heart failure's complexity" writes Jonathon Lederer, a heart specialist at the University of Maryland Biotechnology Institute. "By examining both animal models and human disease, these papers indicate that the role of PLN in the pathogenesis of heart failure might be more complicated than previously thought". The two studies also indicate that we need to better understand inherent differences in cardiac physiology between mice and humans. Dr. Kranias concluded that "these data emphasize a general concern that targeted therapies whose design is based exclusively on results of studies in rodent models, in which phenotypes can differ radically from those observed in the corresponding human genetic condition, may not ultimately be successful in human disease.

CONTACT:
Evangelia G. Kranias
University of Cincinnati Medical Center
Dept Of Pharmacology & Cell Biophysics
231 Albert Sabin Way
ML 0575
Cincinnati, OH 45267-0575
USA
Phone 1-513-558-2377
Fax 1-513-558-2269
E-mail:

Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
10-Mar-2003


Page: 1 2 3

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Spontaneous mutation produces new MAO A/B knockout mouse
3. How an insidious mutation fools DNA replication
4. Using statistics to decipher secrets of natural mutation
5. Rare mutations can significantly increase risk factor for heart disease
6. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
7. LBP-1a gene mutation linked to disruption of normal fetal development
8. Genetic mutation found that is major contributor to type 1 diabetes
9. The mother lode of mutations
10. Gene mutation causes progressive changes to cell structure in children with Progeria
11. Single gene mutation muddying Parkinsons risk forecasts

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... PALM BEACH GARDENS, Fla. , April 11, ... biometric identity management and secure authentication solutions, today ... million contract by Intelligence Advanced Research Projects Activity ... technologies for IARPA,s Thor program. "Innovation ... the onset and IARPA,s Thor program will allow ...
(Date:4/5/2017)... SEATTLE , April 5, 2017  The Allen ... the Allen Cell Explorer: a one-of-a-kind portal and dynamic ... large-scale 3D imaging data, the first application of deep ... edited human stem cell lines and a growing suite ... the platform for these and future publicly available resources ...
(Date:3/30/2017)... 2017  On April 6-7, 2017, Sequencing.com will host ... hackathon at Microsoft,s headquarters in Redmond, ... on developing health and wellness apps that provide a ... Genome is the first hackathon for personal genomics ... companies in the genomics, tech and health industries are ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... ... 09, 2017 , ... The award-winning American Farmer television series will feature 3 ... airs Tuesdays at 8:30aET on RFD-TV. , With global population estimates nearing ten ... to continue to feed a growing nation. At the same time, many of our ...
(Date:10/9/2017)... , ... October 09, 2017 ... ... on October 5, 2017, in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® ... gold standard, video EEG, in detecting generalized tonic-clonic seizures (GTCS) using surface ...
(Date:10/7/2017)... WALTHAM, Mass. , Oct. 6, 2017 /PRNewswire/ ... pioneering work of three scientists, Jacques Dubochet, ... whose breakthrough developments in cryo-electron microscopy ... this technology within the structural biology community. The ... Scientific. Scientists can now routinely produce highly resolved, ...
(Date:10/5/2017)... ... ... LabRoots , the leading provider of educational and interactive virtual events ... cancer research with a month-long promotion supporting the advancement of breast cancer research with ... promo code PinkRibbon to get 10 percent off their purchase of every the “Cancer ...
Breaking Biology Technology:
Cached News: