HOME >> BIOLOGY >> NEWS
Arsenic in drinking water may be linked to cancer Dartmouth study finds

Hanover, NH Exposure to small amounts of arsenic in drinking water may inhibit expression of genes involved in a critical housekeeping function that enables cells to repair damaged DNA, Dartmouth Medical School researchers find. The process, known as DNA repair, is considered a major biological defense in the body's ability to fight cancer.

The study, published in the April issue the International Journal of Cancer, is the first to report diminished expression of DNA repair genes in cells taken directly from humans exposed to arsenic through their environment, according to lead author, Dr. Angeline Andrew, research assistant professor of community and family medicine. She and colleagues Dr. Margaret Karagas, professor of community and family medicine, and Dr. Joshua Hamilton, associate professor of pharmacology and toxicology, compared the arsenic exposure of individuals to expression of DNA repair genes isolated from samples of the same person's blood.

"We were primarily interested in uncovering the mechanism to explain how arsenic causes cancer," said Andrew, noting that arsenic is a well established carcinogen. "This study supports the hypothesis that arsenic may act as a co-carcinogen --not directly causing cancer, but allowing other substances, such as cigarette smoke or ultraviolet light, to cause mutations in DNA more effectively."

The study sheds light on the environmental factors that can increase cancer risk among Americans. The researchers, all faculty in Dartmouth's Center for Environmental Health Sciences and the Norris Cotton Cancer Center, used molecular tools to expand an ongoing study analyzing cancer risk in people exposed to arsenic through their well water.

Previous studies by Karagas and colleagues had established that toenails provide a good biomarker for arsenic exposure -- that is, the arsenic levels in an individual's toenails are well correlated to that person's internal dose of arsenic. When the
'"/>

Contact: Nancy Serrell
Nancy.Serrell@Dartmouth.edu
603-650-1626
Dartmouth Medical School
7-Apr-2003


Page: 1 2

Related biology news :

1. Arsenic in New England wells more widespread than thought
2. Arsenic in Bangladesh drinking wells may be linked to crop irrigation, MIT study finds
3. Arsenic and old telomeres
4. Arsenic and old telomerase: Hopkins researchers unravel effects of arsenic on human cells
5. Marine Life In South Pacific Region Found To Be Impervious To Oceans Highest Arsenic Levels
6. New Hampshire Study Shows Well Water Has Higher Arsenic Levels Than Municipal Water
7. Arsenic Shown To Induce Cancer Remission
8. $6 million appropriation to focus Sandia research on drinking water desalination, removal of arsenic
9. Gene therapy reduces drinking in rats with genetic predisposition to alcoholism
10. Underwater sensor system could protect reservoirs, drinking water
11. New study ties moderate beer drinking to lower heart attack risk

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/6/2017)... 5, 2017 RAM Group , ... new breakthrough in biometric authentication based on a ... properties to perform biometric authentication. These new sensors are ... created by Ram Group and its partners. This sensor ... supply chains and security. Ram Group is a ...
(Date:4/18/2017)... , April 18, 2017  Socionext Inc., a global expert in ... media edge server, the M820, which features the company,s hybrid codec ... provided by Tera Probe, Inc., will be showcased during the upcoming ... NAB show at the Las Vegas Convention ... Click ...
(Date:4/13/2017)... 13, 2017 According to a new market research ... Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and ... is expected to grow from USD 14.30 Billion in 2017 to USD ... 17.3%. ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017 International research firm Parks Associates ... will speak at the TMA 2017 Annual Meeting , October 11 ... in the residential home security market and how smart safety and security ... Parks Associates: ... "The residential security ...
(Date:10/9/2017)... , Oct. 9, 2017  BioTech Holdings announced ... by which its ProCell stem cell therapy prevents ... ischemia.  The Company, demonstrated that treatment with ProCell ... limbs saved as compared to standard bone marrow ... HGF resulted in reduction of therapeutic effect.  ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... October 5, 2017, in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System ... standard, video EEG, in detecting generalized tonic-clonic seizures (GTCS) using surface electromyography ...
(Date:10/6/2017)... ... 06, 2017 , ... The HealthTech Venture Network (HTVN) is ... fourth annual Conference where founders, investors, innovative practitioners and collaborators are invited to ... showcasing early stage digital health and med tech companies. , This day-long event ...
Breaking Biology Technology:
Cached News: