HOME >> BIOLOGY >> NEWS
As Vitamin B-6 levels go down, numbers of DNA strand breaks go up

Taking baseline data on the first day of a Washington State University study, researchers found that four of six young, healthy moderate smokers -- men and women who smoked less than a pack a day -- had unacceptably low blood levels of Vitamin B-6, a vitamin believed to be protective against the DNA damage that can lead to cancers. Only one of the otherwise comparable non-smokers had unacceptable Vitamin B-6 status. After three months of consuming increasingly high levels of dietary and/or supplemental Vitamin B-6, the smokers eventually reached acceptable levels. But they never caught up with their non-smoking counterparts. Considering Vitamin B-6's role in DNA synthesis and repair, these results further convinced the researchers that the current RDA for this critical vitamin is too low for even moderate smokers and could be too low for the population as a whole.

Dr. Terry Shultz presented the study at the Experimental Biology 2003 meeting in San Diego, as part of the American Society for Nutritional Sciences program.

In several large population studies, people with a higher intake of Vitamin B-6 were found to have a lower risk of colon, prostate, lung, gastric and pancreatic cancers. The good news from this study, says Dr. Shultz, is that adding Vitamin B-6 to the diet rapidly improved both smokers' and non-smokers' Vitamin B-6 status and, equally rapidly, decreased the number of DNA strand breaks in both groups.

That makes sense biochemically, he says. The body uses Vitamin B-6 to convert the vitamin folate to a form that can produce thymine, a component of DNA. If the body doesn't have enough Vitamin B-6, it doesn't make enough thymine and it tries to make do by substituting uracil. Uracil is not a normal component of DNA, and the normal DNA repair mechanisms of the cell become stressed. This inefficiency in the normal repair mechanisms leads to breaks in DNA strands and instability of chromosomes -- possible first steps in th
'"/>

Contact: Sarah Goodwin
eb3press@bellsouth.net
770-270-0989
Federation of American Societies for Experimental Biology
14-Apr-2003


Page: 1 2 3

Related biology news :

1. Vitamins do little to prevent recurrent stroke
2. Vitamin C may protect against ulcer-causing bacteria, study finds
3. Vitamin D analog found to boost radiation
4. UC Riverside biochemists develop technology to increase Vitamin C in plants
5. Vitamin D may be crucial in preventing colon cancer
6. Vitamin C transporter gene discovery in mice
7. Vitamin E and aspirin delay heart disease in mice even with high cholesterol levels
8. Rat genes increase Vitamin C in plants
9. Vitamin C produces gene-damaging compounds, test-tube study in Science reports
10. Penn study finds signs folic acid and Vitamin B12 may lessen some ill effects of SMA
11. Vitamin deficiency may exacerbate motor neuron disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2018)... ... July 31, 2018 , ... GSL Biotech ... with LabArchives , the leading cloud-based Electronic Lab Notebook (ELN) platform. , ... researchers to store all of their research data records in a secure, compliant online ...
(Date:7/29/2018)... ... 29, 2018 , ... Dr. William Plikerd, an evidence-based energy healer, today announces ... immunity and to combat inflammation and autoimmune disorders. , The preclinical research assessed ... reported:, Up to 260% increase overall immunity as seen ...
(Date:7/26/2018)... ... July 25, 2018 , ... Boston Biotech Conferences will ... 4, 2018 at The Hilton Boston Back Bay Hotel. This peer-to-peer meeting provides ... and dissect the most relevant deals in biotech. , George Golumbeski recently joined ...
Breaking Biology News(10 mins):
(Date:8/7/2018)... ... August 06, 2018 , ... Slone Partners, ... the placement of Dr. Paul Harney as President, North America at Prescient Healthcare ... and enhancing client satisfaction. He was also named to Prescient’s Board of Directors. ...
(Date:7/31/2018)... ... July 31, 2018 , ... ... years, announces the launch of their new website. The new website has been ... the site. Mahoney partnered with Proceed Innovative to build a website created for ...
(Date:7/25/2018)... ... July 25, 2018 , ... Vium, Inc. ... Digital Vivariumâ„¢ and Vium Cloud approach to accelerate preclinical drug discovery and development, ... the company announced the appointment of Jeff Caron to the newly formed role ...
(Date:7/24/2018)... ... July 24, 2018 , ... R3 Stem Cell is now offering regenerative therapies ... offered by Double Board Certified providers, with outcomes significantly improving patient quality of life. ... have done nothing to help repair and regenerate damaged lung tissues. Stem cell ...
Breaking Biology Technology:
Cached News: