HOME >> BIOLOGY >> NEWS
As harmful as osteoporosis but less well known - New research better explains sarcopenia

self-reported difficulty with mobility tasks, thus suggesting a role of IGF-I in the causal pathway leading to disability in the elderly. Additional research conducted demonstrated that IL-6 inhibits the secretion of IGF-I and its biological activity and that IL-6 overproduction is a mechanism implicated in IGF-I and insulin-like growth factor-binding protein (IGFBP)-3 downregulation. Furthermore, in transgenic mice, an IGF-I deficiency caused by IL-6-related mechanisms determined growth impairment.

A New Study
In light of such evidence, a potential effect of IL-6 and IGF-I in the regulation of the homeostatic mechanisms that maintain an adequate muscle mass can be claimed. One hypothesis is that IL-6-affected IGF-I production may be a potential mechanism by which chronic inflammation causes impaired physical function.

Italian researchers joined a physiologist from the National Institute of Aging in evaluating the relationship of plasma concentrations of IGF-I and IL-6 with muscle function in a population-based sample of older persons. The authors of "Chronic Inflammation and the Effect of IGF-I on Muscle Strength and Power in Older Persons" are Michelangela Barbieri, Emilia Ragno, and Giuseppe Paolisso, from the Department of Geriatric Medicine and Metabolic Diseases, II University of Naples, Naples; Luigi Ferrucci, Annamaria Corsi, and Stefania Bandinelli, at the Laboratory of Clinical Epidemiology, Italian National Research Council of Aging, Geriatric Department, Florence; Massimiliano Bonafe and Claudio Franceschi, from the Department of Experimental Pathology, University of Bologna, Bologna; Fabiola Olivieri and Simona Giovagnetti, from Italian National Research Centers on Aging, Ancona, all in Italy; and Jack M. Guralnik, at the Epidemiology, Demography, and Biometry Laboratory, National Institute of Aging, Bethesda, MD. Their findings appear in the March 2003 edition American Journal of Physiology--Endocrinology and Metabolism, one o
'"/>

Contact: Donna Krupa
djkrupa1@aol.com
703-527-7357
American Physiological Society
2-Apr-2003


Page: 1 2 3 4 5 6

Related biology news :

1. Excess thyroid hormone harmful to fetus
2. Figs may inhibit growth and survival of harmful microbes in food
3. Study of Cape Cod Seashore finds off-road vehicles harmful to beach fauna
4. Is a single bout of exercise helpful or harmful in getting a good nights sleep?
5. Preventative bed rest during pregnancy may be more harmful than helpful
6. Kidney injurys harmful effects on bones blocked in mice
7. Gene may protect against heart disease rather than be harmful as previously thought
8. Breastfeeding may compensate for harmful effects of smoking during pregnancy
9. Female hormones found to protect against harmful effects of fructose
10. URI oceanographers study effects of harmful blooms and red tides on Narragansett Bay
11. Enzyme once thought harmful to Alzheimers patients now appears key to future treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2020)... CHICAGO and FORT WORTH, Texas (PRWEB) , ... ... ... clinical stage biopharmaceutical company, announced today that interim results from their 1801 Phase ... Society of Clinical Oncology (ASCO) Annual Meeting which will take place virtually on ...
(Date:5/21/2020)... ... May 21, 2020 , ... ... background and medical screening, announces the launch of a testing service aimed ... safe. The new service is provided by ClearStar’s Medical Information Services (“MIS”) ...
(Date:5/21/2020)... ... May 20, 2020 , ... Law Enforcement has always been a highly stressful ... The positions of these men and women put them constantly in harm’s way both ... precisely. Officers have always had to face very high daily stress. Now, COVID-19 introduces ...
Breaking Biology News(10 mins):
(Date:6/11/2020)... ... June 09, 2020 , ... TRX Systems, developer of NEON® ... Solution, a highly accurate, contact tracing solution for identification of employees who may ... core disease control measure, is a key strategy for preventing further spread of ...
(Date:5/30/2020)... ... 2020 , ... The Conference Forum is pleased to announce ... the unique role of the Chief Medical Officer in the biotech industry. The ... practices and career development of CMOs and Heads of R&D from different therapeutic ...
(Date:5/21/2020)... ... 19, 2020 , ... Experienced periodontist in Eden Prairie, MN, Dr. Andres Sanchez, ... through PIEZOSURGERY® technology. PIEZOSURGERY uses ultrasonic vibrations to gently cut bone in ... for dental implants, especially when the implants need to be placed in a sensitive ...
(Date:5/15/2020)... (PRWEB) , ... May 14, 2020 , ... This new ... unforeseen and the most pressing questions answered quickly as the need arises. Lachman’s OnCall ... offering valuable advice at affordable rates. , Lachman OnCall™ SMEs are available normal ...
Breaking Biology Technology:
Cached News: