As harmful as osteoporosis but less well known - New research better explains sarcopenia

than men. In contrast, no gender difference in plasma IGF-I levels was found. In the whole group, age was negatively correlated with handgrip and total power. Plasma IL-6 levels were positively correlated with age and body mass index and negatively correlated with total power and handgrip. Conversely, IGF-I was negatively correlated with age and BMI and positively correlated with total power and handgrip. Both IL-6 and IL-6 receptor serum concentrations were negatively correlated with IGF-I serum concentrations. As expected, IL-6 and IL-6 receptor were positively correlated

No differences in IL-6 plasma levels according to IL-6 promoter polymorphism were found.. Indeed, when stratifying subjects according to levels of plasma IL-6 levels, IL-6 promoter polymorphism was a significant predictor of IL-6 plasma levels (independently of age, sex, and BMI) in subjects at the highest level. In particular, lower plasma IL-6 levels were found in subjects carrying the allele C compared with no carrier subjects. To better investigate how IGF-I and IL-6 plasma levels reciprocally condition their effects on muscle function, all further analyses were performed stratified according to plasma IL-6 level. Subjects with higher plasma IL-6 levels were older and, although the wide age range, had lower free IGF-I concentrations and lower total power and handgrip than subjects in the lowest category.

Furthermore, subjects with elevated plasma IL-6 levels had a greater BMI and higher IL-6 receptor and severity of insulin resistance than subjects in the lowest grouping. A significant association between IL-6, handgrip, and total power was found only in subjects in the third level of plasma IL-6 levels. In contrast, significant association of free IGF-I with handgrip and total power occurred only in subjects at the lowest plasma IL-6 level. These findings suggest the existence of a relationship between IL-6 and IGF-I that reciprocally conditions their effect on muscle fu

Contact: Donna Krupa
American Physiological Society

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