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As harmful as osteoporosis but less well known - New research better explains sarcopenia

nction.

Conclusions
This study provides evidence that higher plasma IL-6 levels and lower plasma IGF-I levels are associated with lower muscle strength and power. However, the reciprocal relationship between IL-6 and IGF-I in their joint effect on muscle function is more complex than previously understood. The role of IL-6 in the development of disability in older persons has been documented widely. Elevated plasma IL-6 levels are associated with high mortality in the elderly, and higher plasma IL-6 levels are often found in older persons who are disabled in activities of daily living. It has been proposed that the high risk of disability associated with high IL-6 serum levels is explained by the catabolic effect of IL-6 on muscle, which results in accelerated sarcopenia. However, the true effect of IL-6 on muscle has not been investigated fully. IL-6 plays a central role in the inflammatory response. In addition to its multiple effects at inflammation sites, IL-6 also induces the synthesis of the hepatic acute phase inflammation proteins, such as C-reactive protein, haptoglobin, and fibrinogen, while inhibiting the synthesis of others, such as IGF-I.

This study also explained a multifaceted relationship between plasma IL-6 and IGF-I that conditions the effect of these two mediators on muscle function. Based on the findings, and the literature, and in accordance with some literature, it is reasonable to hypothesize that a high level of inflammation, documented by high plasma IL-6 levels, might negatively affect muscle function through three different mechanisms as follows: 1) IL-6 directly affects muscle strength; 2) IL-6 inhibits the synthesis of IGF-I; and 3) IL-6 blocks the effect of IGF-I. These possibilities, although not definitively proved, are supported by the following findings of our study. 1) IL-6 was an independent predictor of handgrip and muscle power, especially in subjects with the highest level of plasma IL-6 levels, suggesti
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Contact: Donna Krupa
djkrupa1@aol.com
703-527-7357
American Physiological Society
2-Apr-2003


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