HOME >> BIOLOGY >> NEWS
Asbestos cancer breakthrough

Seattle--Researchers at the Pacific Northwest Research Institute (PNRI) have reported the development of a blood test for mesothelioma, a highly aggressive lung cancer caused by asbestos exposure.

A PNRI team led by Dr. Ingegerd Hellstrom, and an Australian team, led by Dr. Bruce Robinson, of the University of Western Australia, conducted the research, which appears in the November 15th issue of Lancet. The new test promises a simple technique for diagnosing and monitoring mesothelioma early in its progress, when therapy is more likely to be successful. Fujirebio Diagnostics, Inc. (FDI) of Malvern, PA, a leading oncology diagnostic company, has acquired an exclusive license from PNRI to develop a commercial test for worldwide distribution.

According to Hellstrom, mesothelioma cells release distinctive molecular markers, SMR (soluble mesothelin-related proteins), into the blood stream. Hellstrom and her colleagues have identified this group of markers and have developed a test to detect them with great specificity.

In blood samples gathered from 273 individuals, researchers found that 84% of those with mesothelioma exhibited high levels of SMR. Only 1.9% of those with other forms of cancer or lung disease had any increased SMR, and patients who were healthy and had not been exposed to asbestos showed no biomarker increase.

"This is a very important breakthrough in the diagnosis and treatment of mesothelioma," Hellstrom explains. "Currently, no blood test exists to detect this cancer and the new biomarker will help doctors see the disease that so far has required much more complicated and expensive tests, and that even then has often gone undetected."

Fujirebio is in the process of initiating the clinical development and commercialization of the mesothelioma test. Dr. Daniel O'Shannessy, FDI's Chief Scientific Officer, says that this new assay "will provide, for the very first time, a highly effective way of tracking d
'"/>

Contact: Rich Murphy
rmurphy@pnri.org
206-726-1200
Pacific Northwest Research Institute
13-Nov-2003


Page: 1 2

Related biology news :

1. Jefferson Scientists Discover Mechanism Of Viral Link To Disease Commonly Associated With Asbestos
2. Leader in cancer treatment and prevention research honored
3. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
4. Chemical derived from vitamin-E shows early promise as cancer drug
5. New molecular link key to cellular proteins involved in cancer progression, other diseases
6. Phase II trials of second-generation antisense cancer drug planned following successful early study
7. Trial shows which brain cancer patients benefit from temozolomide
8. Genetic differences might help distinguish thyroid cancers
9. Evidence builds for potential new cancer drug target
10. New sequence involved in DNA replication timing may aid in cancer detection
11. Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 24, 2020 , ... Elgia Therapeutics , a ... diseases, today announced that Dr. Stacie Canan has joined the company as its ... served as Executive Director of Global Health at Bristol Myers Squibb (formerly Celgene), ...
(Date:8/23/2020)... ... August 21, 2020 , ... The August ... published and is now available on the company’s global website. Crystallography Times—an electronic ... community, presenting current news and crystallographic research. , The latest issue of ...
(Date:8/21/2020)... ... August 20, 2020 , ... NDA Partners Chairman ... Operations executive with expertise in clinical trial planning and feasibility, regulatory inspection readiness, ... Consultant. Throughout his career, Mr. Movahhed has helped design and manage oncology, neurology, ...
Breaking Biology News(10 mins):
(Date:8/7/2020)... ... 06, 2020 , ... VGXI, a highly regarded CDMO supporting ... purchase of greenfield for a new, expanded manufacturing facility. The site is located ... the initial acquisition, with an option to purchase an additional 21 acres for ...
(Date:7/31/2020)... , ... July 29, 2020 , ... ... solid-state radar transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, ... that can drive one or two switches in a push-pull configuration; yielding fast ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... sciences industry, today announced the release of its signature product called Beacon ... Liaisons (MSLs) and other field medical professionals. , Beacon helps MSLs ...
(Date:7/18/2020)... ... 17, 2020 , ... dicentra , a leading Contract ... industries, is pleased to announce that Charles Galea has joined its clinical trials ... is an accomplished and results-driven sales executive with over 10 years of expertise ...
Breaking Biology Technology:
Cached News: