HOME >> BIOLOGY >> NEWS
Aspirin Decreases Genetic Mutations Associated With Inherited Colon Cancer

A new study suggests that aspirin will be a useful chemopreventative for Hereditary Colon Cancer patients. Aspirin may prevent the development of a particular type of common hereditary colorectal cancer in those at high risk for the disease.

Scientists at Jefferson Medical College believe they've uncovered a molecular mechanism by which aspirin interferes with colorectal cancer development in those individuals who carry particular gene mutations that makes them very likely to get the disease.

"Aspirin is a well known prophylaxis for cancer," says molecular geneticist Richard Fishel, Ph.D., professor of microbiology and immunology at the Kimmel Cancer Center of Thomas Jefferson University in Philadelphia, who with Josef Rschoff, M.D., of the University of Regensburg, Germany, led the research. "The new twist is that aspirin suppresses the accumulation of mutations that are the cause of a common inherited cancer." Similar mutations are found in 5-10% of sporadic colorectal, endometrial and ovarian cancers.

Their work appears September 15 in the Proceedings of the National Academy of Sciences.

Drs. Fishel, Rschoff and their colleagues examined human colon cancer cell lines with defective mismatch repair genes, which are necessary to fix normal cell damage that occurs when cells divide and multiply. These mismatch repair genes were discovered by Dr. Fishel and Dr. Richard Kolodner (now at the Ludwig Institute for Cancer Research in San Diego) in 1993 to be the cause of the most common form of hereditary cancer known as Hereditary Nonpolyposis Colorectal Cancer (HNPCC).

The scientists then treated the colon tumor cells with two drugs: aspirin and sulindac, which are both nonsteroidal anti-inflammatory drugs and known cancer preventatives. They found that the drugs largely suppressed the genetic instability that underlies the development of cancer in HNPCC.

"Our results appear to suggest a very simple
'"/>

Contact: Steve Benowitz
steven.benowitz@mail.tju.edu
(215) 955-6300
Thomas Jefferson University
14-Sep-1998


Page: 1 2 3 4

Related biology news :

1. Aspirin use safe and effective in patients with abnormal red cell counts (or with polycythemia)
2. Aspirin may not be strong enough to prevent clots in some heart patients
3. Aspirin could reduce the risk of deadly infections
4. Aspirin prevents polyps in colon cancer patients
5. Aspirin inhibits ovarian cancer growth, lab study finds
6. Aspirin targets key cell that triggers organ rejection and other immune responses, report University of Pittsburgh researchers in journal article
7. Aspirin use may increase pancreatic cancer risk
8. How Super Are The "Super Aspirins"? -- New COX-2 Inhibitors May Elevate Cardiovascular Risk
9. Study Shows Aspirin Blocks "Plant Pain"
10. Aspirins Preventive Action In Heart Attacks Tied To Genetics
11. Vitamin E Supplement Decreases Autoantibodies To Oxidized LDL

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/28/2020)... JUPITER, Fla. (PRWEB) , ... June 25, 2020 , ... ... will focus on innovations in accelerated Point of Care Testing solutions (POCT). Check local ... labs. Samples are collected at medical offices and are shipped to labs throughout the ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... today announced that the company has received ISO9001:2015 certification for the development ... research industries. The decision to pursue ISO9001 accreditation demonstrates Kemp’s commitment to ...
(Date:6/23/2020)... ... June 22, 2020 , ... The field of quantitation of large molecules ... have dominated this area. However, the use of mass spectrometry in this field has ... the question “How do you choose which approach to use (LBA or MS)?” ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 11, 2020 , ... ... available for free its new white paper – Simulated Transport Methodologies. Regulatory ... today’s biologics licensing application (BLA). In response, Modality Solutions shares an explanation ...
(Date:8/3/2020)... ... August 03, 2020 , ... Introducing Ardent Animal Health ... growth, , Known as MediVet Biologics since its formation in ... The new Ardent Animal Health will build on its base of innovative therapies ...
(Date:7/31/2020)... Mass. (PRWEB) , ... July 29, 2020 , ... ... wire that can combine up to three different materials for use with CRM, ... combine up to three materials to meet specific design requirements, performance, and cost ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... software for the life sciences industry, today announced the release of its ... specifically for Medical Science Liaisons (MSLs) and other field medical professionals. ...
Breaking Biology Technology:
Cached News: