HOME >> BIOLOGY >> NEWS
Aspirin Decreases Genetic Mutations Associated With Inherited Colon Cancer

A new study suggests that aspirin will be a useful chemopreventative for Hereditary Colon Cancer patients. Aspirin may prevent the development of a particular type of common hereditary colorectal cancer in those at high risk for the disease.

Scientists at Jefferson Medical College believe they've uncovered a molecular mechanism by which aspirin interferes with colorectal cancer development in those individuals who carry particular gene mutations that makes them very likely to get the disease.

"Aspirin is a well known prophylaxis for cancer," says molecular geneticist Richard Fishel, Ph.D., professor of microbiology and immunology at the Kimmel Cancer Center of Thomas Jefferson University in Philadelphia, who with Josef Rschoff, M.D., of the University of Regensburg, Germany, led the research. "The new twist is that aspirin suppresses the accumulation of mutations that are the cause of a common inherited cancer." Similar mutations are found in 5-10% of sporadic colorectal, endometrial and ovarian cancers.

Their work appears September 15 in the Proceedings of the National Academy of Sciences.

Drs. Fishel, Rschoff and their colleagues examined human colon cancer cell lines with defective mismatch repair genes, which are necessary to fix normal cell damage that occurs when cells divide and multiply. These mismatch repair genes were discovered by Dr. Fishel and Dr. Richard Kolodner (now at the Ludwig Institute for Cancer Research in San Diego) in 1993 to be the cause of the most common form of hereditary cancer known as Hereditary Nonpolyposis Colorectal Cancer (HNPCC).

The scientists then treated the colon tumor cells with two drugs: aspirin and sulindac, which are both nonsteroidal anti-inflammatory drugs and known cancer preventatives. They found that the drugs largely suppressed the genetic instability that underlies the development of cancer in HNPCC.

"Our results appear to suggest a very simple
'"/>

Contact: Steve Benowitz
steven.benowitz@mail.tju.edu
(215) 955-6300
Thomas Jefferson University
14-Sep-1998


Page: 1 2 3 4

Related biology news :

1. Aspirin use safe and effective in patients with abnormal red cell counts (or with polycythemia)
2. Aspirin may not be strong enough to prevent clots in some heart patients
3. Aspirin could reduce the risk of deadly infections
4. Aspirin prevents polyps in colon cancer patients
5. Aspirin inhibits ovarian cancer growth, lab study finds
6. Aspirin targets key cell that triggers organ rejection and other immune responses, report University of Pittsburgh researchers in journal article
7. Aspirin use may increase pancreatic cancer risk
8. How Super Are The "Super Aspirins"? -- New COX-2 Inhibitors May Elevate Cardiovascular Risk
9. Study Shows Aspirin Blocks "Plant Pain"
10. Aspirins Preventive Action In Heart Attacks Tied To Genetics
11. Vitamin E Supplement Decreases Autoantibodies To Oxidized LDL

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2019)... (PRWEB) , ... August 21, 2019 , ... ... E. coli cell line for rapid and low-cost biomanufacturing of complex protein therapeutics, ... Formerly a member of AbSci's Scientific Advisory Board, Dr. Larimore brings more than ...
(Date:8/15/2019)... ... August 15, 2019 , ... Deep Science Ventures ... Food and Agriculture practice, a new unit dedicated to building 100 companies over the ... raw materials and supply chains. , Deep Science Ventures was founded to create ...
(Date:8/14/2019)... ... August 14, 2019 , ... Carterra® ... they have opened a Customer Experience Center (CEC) and office in Munich, Germany. ... office. , The Munich CEC will be a place for researchers throughout Europe ...
Breaking Biology News(10 mins):
(Date:9/17/2019)... ... September 16, 2019 , ... MyBioGate Global Healthcare Innovation ... Biotech Week Boston, a forum organized by MyBioGate, Inc. and CUBIO Innovation Center ... a careful process of evaluation, twelve companies out of over 200 applications were ...
(Date:9/11/2019)... (PRWEB) , ... September 10, 2019 , ... ... broadcast 1Q/2020 will educate about the latest developments in genome sequencing analysis. Check ... about the innovation taking place at Rivermap Research & Consulting and will explore ...
(Date:9/8/2019)... NEW YORK (PRWEB) , ... September 04, 2019 ... ... New York Academy of Sciences announced today the three Winners and ... Supporting outstanding postdoctoral scientists from academic research institutions across New York, New Jersey, ...
(Date:9/2/2019)... N.J. and LIÉGE, Belgium (PRWEB) , ... September ... ... of solutions for epigenetics research and in vitro diagnostics, has launched the industry’s ... uncover the underlying biological meaning of epigenetic data and other data types. ...
Breaking Biology Technology:
Cached News: