Aspirin may not be strong enough to prevent clots in some heart patients

While an aspirin a day helps keep a heart attack at bay, it may need reinforcement to totally prevent blood clots among patients with chest pain, a Johns Hopkins study shows.

Researchers took blood samples from 33 patients hospitalized for chest pain at Johns Hopkins Bayview Medical Center. Eighteen patients had acute coronary syndrome, or heart-disease-related chest pain, and 15 had non-cardiac chest pain. All took aspirin at 81 to 325 milligrams per day.

The Hopkins team treated the samples with very low doses of ADP and epinephrine medications that allow platelets, tiny disk-shaped structures within the blood, to clump together. They found that despite treatment with aspirin, platelets clotted together 5 percent to 10 percent more among the patients with heart disease than those without.

The work is to be presented Nov. 10 at the American Heart Association's 76th Scientific Sessions in Orlando, Fla.

"Even though these patients were receiving aspirin therapy, they still had very active platelets," says Marlene S. Williams, M.D., lead author of the study and assistant professor of medicine. The more the platelets clump together, the higher the chance of a clot forming, leading to a heart attack, she says.

Patients already taking daily aspirin should continue, Williams says. Her further studies will investigate the addition of other anti-clotting agents to aspirin therapy, and the study of abnormal genes that might affect platelet function.


Contact: Karen Blum
Johns Hopkins Medical Institutions

Page: 1

Related biology news :

1. Aspirin use safe and effective in patients with abnormal red cell counts (or with polycythemia)
2. Aspirin could reduce the risk of deadly infections
3. Aspirin prevents polyps in colon cancer patients
4. Aspirin inhibits ovarian cancer growth, lab study finds
5. Aspirin targets key cell that triggers organ rejection and other immune responses, report University of Pittsburgh researchers in journal article
6. Aspirin use may increase pancreatic cancer risk
7. How Super Are The "Super Aspirins"? -- New COX-2 Inhibitors May Elevate Cardiovascular Risk
8. Aspirin Decreases Genetic Mutations Associated With Inherited Colon Cancer
9. Study Shows Aspirin Blocks "Plant Pain"
10. Aspirins Preventive Action In Heart Attacks Tied To Genetics
11. When suns too strong, plankton make clouds

Post Your Comments:

(Date:7/23/2019)... ... , ... NanoFUSE is pleased to announce the ... spine and orthopedic use. Bioactive glass is a calcium phosphate coated silica that ... orthopedics for over 30 years and now NanoFUSE Biologics has used advanced research ...
(Date:7/19/2019)... ... July 19, 2019 , ... ... and Crystalline States – Insights from Synchrotron X-ray Pair Distribution (SXPDF) Studies”. The ... with Chris Benmore of Argonne National Laboratory and Gabriel de Araujo of the ...
(Date:7/17/2019)... Pa. (PRWEB) , ... July 15, 2019 , ... ... of computational science expertise exclusively for Life Sciences and Healthcare companies, announces the ... provide critical advisory services and strategic direction to start-up and emerging bio-pharma companies ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... Fla. (PRWEB) , ... June 10, 2019 , ... ... in science and technology in an upcoming episode, scheduled to broadcast 4Q/2019. Check ... the Eppendorf Group) and will educate viewers about how its technology facilitates laboratories ...
(Date:6/11/2019)... POWAY, Calif. (PRWEB) , ... June 11, 2019 ... ... parent company of Personalized Stem Cells Inc. (PSC) , has announced that ... of Public Health, Food and Drug Branch for manufacturing. This is an ...
(Date:5/31/2019)... ... May 29, 2019 , ... For many years, the primary forms of cancer ... breakthrough therapies. Advances in immuno-oncology have led to the advent of Chimeric Antigen Receptor ... T cell receptors known as “CARs”. The CAR enables the final product to produce ...
(Date:5/31/2019)... ... May 30, 2019 , ... Object ... announce the strategic acquisition of Metabiologics, Inc., a globally recognized leader in the ... ownership and commercialization rights to a full spectrum of botulinum neurotoxins, as well ...
Breaking Biology Technology:
Cached News: