HOME >> BIOLOGY >> NEWS
Aspirin targets key cell that triggers organ rejection and other immune responses, report University of Pittsburgh researchers in journal article

Animal studies suggest there could be an effective, cheap approach to preventing rejection

PITTSBURGH, June 5 -- University of Pittsburgh researchers have identified a new cellular target for aspirin, shedding light on the mechanisms of the most widely used drug in the world and raising a set of intriguing questions, including whether aspirin could be useful for preventing organ rejection.

In the June 15 issue of the Journal of Immunology, the researchers report for the first time that aspirin has a profound effect on bone-marrow derived dendritic cells -- the powerful immune system cells that are responsible for initiating an immune response -- by preventing their maturation and hence, their ability to signal other cells to attack.

The findings help to explain why aspirin taken in high doses significantly reduces inflammation and provides relief to patients with various autoimmune diseases, including arthritis and rheumatic fever, says lead author Holger Hackstein, M.D., a visiting research fellow at the University of Pittsburgh's Thomas E. Starzl Transplantation Institute, who is working in the lab of Angus Thomson, Ph.D., D.Sc., professor of surgery and molecular genetics and biochemistry and senior author on the paper.

And while the research used a mouse model to look at aspirin's effect on myeloid dendritic cells, the findings point to possible novel therapies for patients with autoimmune diseases as well as approaches that could induce tolerance in organ transplant recipients. The researchers plan a series of animal studies to determine if aspirin can help prevent organ rejection. Specifically, they will be looking to see what role aspirin has in preventing dendritic cells from calling in the troops of T and B lymphocytes that directly attack transplanted organs.

"These findings provide new insight into the immunopharmacology of aspirin. Moreover, exposure to this readily available drug provides a simple, inexpe
'"/>

Contact: Lisa Rossi
rossiL@msx.upmc.edu
412-647-3555
University of Pittsburgh Medical Center
4-Jun-2001


Page: 1 2 3

Related biology news :

1. Aspirin use safe and effective in patients with abnormal red cell counts (or with polycythemia)
2. Aspirin may not be strong enough to prevent clots in some heart patients
3. Aspirin could reduce the risk of deadly infections
4. Aspirin prevents polyps in colon cancer patients
5. Aspirin inhibits ovarian cancer growth, lab study finds
6. Aspirin use may increase pancreatic cancer risk
7. How Super Are The "Super Aspirins"? -- New COX-2 Inhibitors May Elevate Cardiovascular Risk
8. Aspirin Decreases Genetic Mutations Associated With Inherited Colon Cancer
9. Study Shows Aspirin Blocks "Plant Pain"
10. Aspirins Preventive Action In Heart Attacks Tied To Genetics
11. Images of tail of protein needed for cell multiplication suggest anticancer drug targets

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/26/2017)... 25, 2017  Securus Technologies, a leading provider ... public safety, investigation, corrections and monitoring, announces the ... "Too often, too many offenders return ... jails are trying to tackle this ongoing problem ... and family members. While significant steps are underway, Securus ...
(Date:2/22/2017)... , Feb. 22, 2017 With the ... ABI Research identifies four technologies that innovative and ... secure significant share in the changing competitive landscape: ... passive authentication.   "Companies can no ... to security," says Dimitrios Pavlakis , Industry ...
(Date:2/21/2017)... 2017 Der weltweite Biobanking-Sektor wird ... einem Gespräch mit mehr als 50 Vertretern aus verschiedenen Branchen ... gilt, um diese Prognose zu realisieren. ... Zu den ... finanziellen Mittel für die Biobank, die Implementierung Zeit sparender ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... ... 29, 2017 , ... (March 29, 2017) — Nerium ... as an active member of the Mexican Direct Selling Association A.C. (AMVD ... in relationship marketing. This professional organization fosters loyal and fair competition among companies ...
(Date:3/29/2017)... ... March 29, 2017 , ... ... cell-based assays, disperses a quarterly travel award to noteworthy scientists who will be ... announced that its new round of awards are being given to two postdoctoral ...
(Date:3/29/2017)... - The University of Missouri Research Reactor (MURR ® ... International, and General Atomics (GA), announce that MURR,s License ... Nuclear Regulatory Commission (NRC). This marks a critical step ... operational, production from this facility will be capable of ... currently must be imported from outside North ...
(Date:3/28/2017)... ... March 28, 2017 , ... NetDimensions ... paper-based processes and enhance training plan management for consistent implementation of standards and ... with the SHL Group to help improve and streamline their training and employee ...
Breaking Biology Technology:
Cached News: