Asthma patients cautioned about melatonin

People with asthma should consider limiting the use of melatonin as a sleep aid, according to researchers at National Jewish Medical and Research Center. Pulmonologist Rand Sutherland, M.D., M.P.H., and his colleagues report in the September 2003 issue of the Journal of Allergy and Clinical Immunology that higher levels of melatonin were associated with an overnight loss of lung function in asthma patients. Previous studies by the same group have shown that melatonin induces the release of chemicals that promote inflammation, a hallmark symptom of asthma.

"For patients whose asthma worsens at night, we found that higher levels of naturally occurring melatonin are associated with impaired lung function," said Dr. Sutherland. "Those findings, on top of previous ones linking melatonin to inflammation, suggest that all patients with asthma should avoid using melatonin supplements until more is known about their safety."

Melatonin, a hormone secreted by the pineal gland in the brain, is an important regulator of circadian rhythms in the body, especially sleep. It is released at night, generally beginning in the evening hours before bedtime, peaking in the middle of the night, and ending about the time people awaken. Because of its association with sleep, over-the-counter melatonin has become a popular dietary supplement sold as a treatment for jet lag and insomnia.

However, melatonin has also been shown to enhance inflammation in cell and animal studies of asthma. Airway inflammation is one reason people with asthma have difficulty breathing. A significant portion of asthma patients experience increased symptoms at night. Dr. Sutherland and his colleagues hypothesized that melatonin may play a role in this nighttime worsening of asthma.

The researchers had seven people with nocturnal asthma, 13 with non-nocturnal asthma, and 11 healthy controls establish a regular sleep schedule for seven days. On the eighth night, small blood samples were

Contact: William Allstetter
National Jewish Medical and Research Center

Page: 1 2

Related biology news :

1. Asthma could be several diseases masquerading as one
2. New genetic technique delivers knockout blow to Asthma Virus
3. Asthmatic blacks get less high-quality asthma care
4. Asthma-linked genes discovered at Berkeley lab
5. Study Suggests New Approach To Asthma
6. Key Asthma And Allergy Molecule Pictured
7. UCSF Team Identifies Two Key Molecules In Asthma; Important Finding For New Therapies That Treat Disease At Cell Level
8. House Dust Mite Busters No Good For Asthma Sufferers
9. Allergy And Asthma-Exaceberating Mites, Molds And Pollens On The Rise Due To El Niño . . . La Niña
10. Three-Dimensional Structure Of Human Lung Tryptase Determined, An Enzyme Involved In Allergic Asthma
11. Trial shows which brain cancer patients benefit from temozolomide

Post Your Comments:

(Date:10/4/2017)... Ill. , Oct. 4, 2017  GCE Solutions, a global ... new data and document anonymization solution on October 4, 2017. Shadow ... pharmaceutical field to comply with policy 0070 of the European Medicines ... and data. ... by GCE Solutions ...
(Date:6/30/2017)... ARLINGTON, Va. , June 30, 2017 /PRNewswire-USNewswire/ ... a leading developer and supplier of face and ... the ATA Featured Product provider program. ... created an innovative way to monitor a driver,s ... benefit greatly from being able to detect fatigue ...
(Date:5/16/2017)... TEANECK, N.J. , May 16, 2017  Veratad ... leading provider of online age and identity verification solutions, ... the K(NO)W Identity Conference 2017, May 15 thru May ... Ronald Regan Building and International Trade Center. ... across the globe and in today,s quickly evolving digital ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back for its ... 2018 in San Francisco, CA. The Summit brings together current and former FDA office ... directors and government officials from around the world to address key issues in device ...
(Date:10/11/2017)... Tbilisi, Georgia (PRWEB) , ... October 11, 2017 , ... ... disaster, taking the lives of over 5.5 million people each year. Especially those living ... the greenovative startup Treepex - based in one of the most pollution-affected countries globally ...
(Date:10/10/2017)... Angeles, CA (PRWEB) , ... ... ... Inc., a development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, ... uses of targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in ...
Breaking Biology Technology:
Cached News: