HOME >> BIOLOGY >> NEWS
Austrian scientists identify gene involved in recurrent miscarriages

Women with a particular variation in a gene that controls the way that blood vessels function have a 60% greater risk of recurrent miscarriage, Professor Clemens Tempfer and colleagues from the University of Vienna School of Medicine report in Europe's leading reproductive medicine journal, Human Reproduction.*

Nearly a fifth of all pregnancies end in miscarriages, but up to two per cent of women suffer recurrent miscarriages i.e. three or more consecutive pregnancy losses before 20 weeks. The research team has found evidence that a variation in a gene - NOS - which is known to be involved in synthesising nitric oxide, could be at least partly to blame.

They compared a group of 105 women who had all suffered recurrent spontaneous miscarriages with a carefully matched control group of 91 postmenopausal women who had never had a miscarriage and who had given birth at least twice.

"Nitric oxide has been implicated in blood vessel disease and damage and nitric oxide synthase (NOS) is known to mediate vascular relaxation," said Professor Tempfer: "We found a significant difference in the genotype frequencies for one variation of the NOS3 gene between the study and control groups."

"This is evidence of a relationship between unexplained recurrent miscarriage and a gene, the product of which is already known to influence the way vascular smooth muscles behave. Given also the role that nitric oxide deficiency plays in high blood pressure, haemorrhage, vascular spasms and infarction, it's reasonable to speculate that carriers of an NOS3 polymorphism are at increased risk for impaired placental function. Displaying this polymorphism is not necessary or sufficient on its own for the development of unexplained recurrent miscarriages, but our data indicate that it does confer a small (1.6-fold) but significantly increased risk.

Professor Tempfer concluded that the findings also added further evidence that endothelium-derived nitri
'"/>

Contact: Margaret Willson
m.willson@mwcommunications.org.uk
44-0-1536-772181
European Society for Human Reproduction and Embryology
26-Jul-2001


Page: 1 2

Related biology news :

1. DNA lends scientists a hand, revealing new chemical reactions
2. Conference at UH opens doors for new scientists, engineers
3. Wisconsin scientists develop quick botox test
4. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
5. Alaska scientists find Arctic tundra yields surprising carbon loss
6. UAF scientists discover new marine habitat in Alaska
7. Information system to help scientists analyze mechanisms of social behavior
8. Zoonotic diseases - European scientists unite to fight diseases
9. Israeli scientists reveal the plan of a key cellular machine
10. Study by Israeli scientists provides insight on DNA code
11. Computer scientists at UH developing nurturing computers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2020)... ... ... A team of researchers at the Icahn School of Medicine at Mount Sinai, ... causes coronavirus disease (COVID-19). This antibody is intended to block the virus from entering ... efforts are being led by Mone Zaidi, MD, PhD, MACP, Director of the Mount ...
(Date:4/22/2020)... (PRWEB) , ... April 21, 2020 , ... ... digital transformation and innovation in technology and compliance, announces a new managed service ... best-in-class trio of alliances – Box, ComplianceQuest, and USDM Life Sciences (USDM) – ...
(Date:4/16/2020)... ... April 15, 2020 , ... With ... to create a vaccine to this novel virus. In an effort to accelerate ... Complex Systems (LRC), is announcing the development of Sample.Exchange, a web-based platform ...
Breaking Biology News(10 mins):
(Date:4/7/2020)... ... April 06, 2020 , ... Gateway Genomics , leading developer of ... SneakPeek Early Gender DNA Tests sold in March, just months after attaining the ... ecommerce product, where a mom could order her kit online, collect a DNA sample ...
(Date:4/1/2020)... AUSTIN, Texas (PRWEB) , ... March 30, 2020 ... ... MD (APMD) and telehealth developer Reliant Immune Diagnostics (RID), formed earlier this year ... the COVID-19 pandemic by creating in-home tests for COVID-19. Company officials are currently?awaiting ...
(Date:4/1/2020)... , ... March 31, 2020 , ... ... (P2) announce the signing of a Joint Development Agreement that builds on ... Research, Inc. is a global leader in the supply of high-quality insect pheromones ...
(Date:3/19/2020)... FREDERICK, Md. (PRWEB) , ... ... ... announces a clinical supply and manufacturing collaboration agreement with pioneering gene circuit ... gene-modified cell therapies for ovarian cancer and other solid tumor indications. The ...
Breaking Biology Technology:
Cached News: