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Award winning researchers reveal potential new role for Glivec

for molecular analysis to select more accurately patients who could benefit from targeted therapeutics. We are confident that this approach will first benefit patients by tailoring their treatments and avoiding unnecessary therapy and often toxic 'trial and error' probabilistic prescriptions. It will also aid regulatory agencies and pharmaceutical companies by speeding up drug development while helping to implement more rational regulatory policies."

Dr McArthur said that one challenge the oncology community faced was working with industry and regulatory agencies to develop strategies for approving novel agents that displayed significant activity in rare diseases. "Possible approaches include registries," he said, "but ultimately, international cooperation in trials such as ours (the Imatinib Target Exploration Study Team ImTEST) will provide the best data."

He added that it was possible that imatinib may turn out to be useful in other rare tumours or diseases, or in rare subsets of more common diseases where PDGFR or other targets are activated.


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Contact: Margaret Willson
m.willson@mwcommunications.org.uk
41-227-612-205
European Organisation for Research and Treatment of Cancer
29-Sep-2004


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