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Awards honor Alt's three decades of genetic cancer research

. As with VDJ recombination, genes are cut and pasted, generating different classes of antibodies (IgM, IgG, IgE, etc.). Again as with VDJ recombination, Alt believes that errors in the "pasting" part of the process may lead to translocations and oncogene (cancer gene) activation, a phenomenon already seen in many human B-cell lymphomas. H2AX may play a protective role here as well, Alt believes, by ensuring that cut ends of genes are properly joined.


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Contact: Susan Craig
susan.craig@childrens.harvard.edu
617-355-6420
Children's Hospital Boston
24-Mar-2004


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TAG: Awards honor Alt three decades genetic cancer research

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