HOME >> BIOLOGY >> NEWS
BRCA mutations not associated with colorectal cancer risk, studies suggest

Two studies in the January 7 issue of the Journal of the National Cancer Institute suggest that mutations in the genes BRCA1 and BRCA2 are not associated with an increased risk of colorectal cancer.

Mutations in BRCA1 and BRCA2, which are present in about 2.5% of the Ashkenazi Jewish population, have been associated with an increased risk of breast and ovarian cancer, but it is unclear whether these mutations also increase the risk of colorectal cancer. Some studies have suggested an increased risk of colorectal cancer among mutation carriers, whereas other studies have found no such association. Current nationally recognized guidelines recommend that all BRCA1/2 mutation carriers be informed that they may be at an increased risk for colorectal cancer.

Tomas Kirchhoff, Ph.D., Kenneth Offit, M.D., and their colleagues at the Memorial Sloan-Kettering Cancer Center in New York compared the incidence of BRCA1/2 mutations in 586 Ashkenazi Jewish patients with colorectal cancer with that of 5,012 patients without a known history of colorectal cancer. The authors found no association between the presence of a BRCA mutation and risk of colorectal cancer.

In a second study, Bethany L. Niell and Stephen B. Gruber, M.D., Ph.D., of the University of Michigan, Ann Arbor, and their colleagues performed genetic testing on 1,422 patients with colorectal cancer and 1,566 control subjects without colorectal cancer in a population-based study in Israel. They also found no association between the presence of a BRCA mutation and the risk of colorectal cancer.

A family history of breast cancer in a female relative was not associated with an increased risk of colorectal cancer, even after adjusting for the presence of a BRCA founder mutation. The authors conclude that Ashkenazi BRCA founder mutations do not confer a strongly elevated risk of colorectal cancer. Similarly, a family history of breast cancer does not appear to be a strong risk factor for
'"/>

Contact: Katherine Arnold
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
6-Jan-2004


Page: 1 2

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Rare mutations can significantly increase risk factor for heart disease
3. The mother lode of mutations
4. Mastectomy dramatically reduces breast cancer risk among women with BRCA1/2 mutations
5. Yeast mutations offer window into human disease
6. Ancient DNA mutations permitted humans to adapt to colder climates, UCI researchers find
7. BRCA mutations do not increase risk of colorectal cancer
8. Researchers describe novel gene mutations associated with Alzheimer disease
9. Major mutations, not many small changes, might lead way to new species
10. Genetics mutations resulting in delayed puberty are focus of MCG study
11. Gene mutations that cause hearing loss discovered

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2019)... ... August 29, 2019 , ... Advancements ... robotics platform in an upcoming episode, which is scheduled to broadcast 1Q/2020. Check ... and commercialization of cost-effective robotic surgical solutions for the treatment of patients suffering ...
(Date:8/27/2019)... (PRWEB) , ... August 26, 2019 , ... Shoreline ... to the strain level, has hired Bill McKenzie as its CEO and Karen Woodward ... to help Shoreline Biome meet growing demand for its products and expand the company’s ...
(Date:8/27/2019)... , ... August 27, 2019 , ... ... science and drug development. This episode is scheduled to broadcast 4Q/2019. Check local ... a biopharmaceutical research, development, investment and manufacturing company. The show will highlight how ...
Breaking Biology News(10 mins):
(Date:8/27/2019)... (PRWEB) , ... August 27, 2019 , ... Dr. Kim ... She recently opened North Peninsula Veterinary Surgical Group , a new surgical practice ... there are plans to expand and add more veterinary specialists as the practice grows. ...
(Date:8/23/2019)... ... August 22, 2019 , ... The EnozoPro® converts ordinary tap water into ... and pathogens on hard surfaces including E. Coli, Salmonella, MRSA, Listeria and Legionella. It ... more information, visit the product page at rovingblue.com , ”At Enozo, our mission is ...
(Date:8/14/2019)... COLLEGE, Pa. (PRWEB) , ... August 13, 2019 ... ... in nuclear receptor and in vitro toxicology testing solutions, announced the appointment of ... healthcare industry experience to the Board. , Mark McLoughlin will lend his healthcare ...
(Date:8/7/2019)... SOLON, Ohio (PRWEB) , ... August 07, 2019 , ... ... with a breakthrough line of soil amendments (soil “probiotics”), including Rhizolizer ® , ... within a year—the largest impact any approach has offered to date. Results from the ...
Breaking Biology Technology:
Cached News: