HOME >> BIOLOGY >> NEWS
BRCA mutations not associated with colorectal cancer risk, studies suggest

Two studies in the January 7 issue of the Journal of the National Cancer Institute suggest that mutations in the genes BRCA1 and BRCA2 are not associated with an increased risk of colorectal cancer.

Mutations in BRCA1 and BRCA2, which are present in about 2.5% of the Ashkenazi Jewish population, have been associated with an increased risk of breast and ovarian cancer, but it is unclear whether these mutations also increase the risk of colorectal cancer. Some studies have suggested an increased risk of colorectal cancer among mutation carriers, whereas other studies have found no such association. Current nationally recognized guidelines recommend that all BRCA1/2 mutation carriers be informed that they may be at an increased risk for colorectal cancer.

Tomas Kirchhoff, Ph.D., Kenneth Offit, M.D., and their colleagues at the Memorial Sloan-Kettering Cancer Center in New York compared the incidence of BRCA1/2 mutations in 586 Ashkenazi Jewish patients with colorectal cancer with that of 5,012 patients without a known history of colorectal cancer. The authors found no association between the presence of a BRCA mutation and risk of colorectal cancer.

In a second study, Bethany L. Niell and Stephen B. Gruber, M.D., Ph.D., of the University of Michigan, Ann Arbor, and their colleagues performed genetic testing on 1,422 patients with colorectal cancer and 1,566 control subjects without colorectal cancer in a population-based study in Israel. They also found no association between the presence of a BRCA mutation and the risk of colorectal cancer.

A family history of breast cancer in a female relative was not associated with an increased risk of colorectal cancer, even after adjusting for the presence of a BRCA founder mutation. The authors conclude that Ashkenazi BRCA founder mutations do not confer a strongly elevated risk of colorectal cancer. Similarly, a family history of breast cancer does not appear to be a strong risk factor for
'"/>

Contact: Katherine Arnold
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
6-Jan-2004


Page: 1 2

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Rare mutations can significantly increase risk factor for heart disease
3. The mother lode of mutations
4. Mastectomy dramatically reduces breast cancer risk among women with BRCA1/2 mutations
5. Yeast mutations offer window into human disease
6. Ancient DNA mutations permitted humans to adapt to colder climates, UCI researchers find
7. BRCA mutations do not increase risk of colorectal cancer
8. Researchers describe novel gene mutations associated with Alzheimer disease
9. Major mutations, not many small changes, might lead way to new species
10. Genetics mutations resulting in delayed puberty are focus of MCG study
11. Gene mutations that cause hearing loss discovered

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2017)... 17, 2017 NXT-ID, Inc. (NASDAQ: NXTD ... filing of its 2016 Annual Report on Form 10-K on Thursday ... ... available in the Investor Relations section of the Company,s website at ... website at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
(Date:4/5/2017)... KEY FINDINGS The global market for stem ... 25.76% during the forecast period of 2017-2025. The rise ... growth of the stem cell market. Download ... The global stem cell market is segmented on the ... cell market of the product is segmented into adult ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... OXFORD, England , Aug. 16, 2017 /PRNewswire/ ... biotech executive search and leadership development, and Virdis Group, global ... created an exclusive alliance that enables clients to leverage the ... "For our clients here in the ... to a diverse population of leadership talent throughout the US, ...
(Date:8/15/2017)... ... August 15, 2017 , ... Nanomedical Diagnostics , ... development, announces the launch of the new NHS Agile biosensor chip . ... data for a wide range of molecules, including small and large molecules, peptides, ...
(Date:8/15/2017)... ... August 15, 2017 , ... Kenall, a leader in ... to stay tightly sealed and perform efficiently for years. The downlights are ideal ... just aren't enough, such as: hospitals; behavioral health facilities; cleanrooms; containment areas; food ...
(Date:8/15/2017)... ... August 15, 2017 , ... ... Now mobile responsive, the new website makes it easy to navigate through the ... Users can now find detailed product information, educational industry content and visit the ...
Breaking Biology Technology:
Cached News: