HOME >> BIOLOGY >> NEWS
BRCA mutations not associated with colorectal cancer risk, studies suggest

Two studies in the January 7 issue of the Journal of the National Cancer Institute suggest that mutations in the genes BRCA1 and BRCA2 are not associated with an increased risk of colorectal cancer.

Mutations in BRCA1 and BRCA2, which are present in about 2.5% of the Ashkenazi Jewish population, have been associated with an increased risk of breast and ovarian cancer, but it is unclear whether these mutations also increase the risk of colorectal cancer. Some studies have suggested an increased risk of colorectal cancer among mutation carriers, whereas other studies have found no such association. Current nationally recognized guidelines recommend that all BRCA1/2 mutation carriers be informed that they may be at an increased risk for colorectal cancer.

Tomas Kirchhoff, Ph.D., Kenneth Offit, M.D., and their colleagues at the Memorial Sloan-Kettering Cancer Center in New York compared the incidence of BRCA1/2 mutations in 586 Ashkenazi Jewish patients with colorectal cancer with that of 5,012 patients without a known history of colorectal cancer. The authors found no association between the presence of a BRCA mutation and risk of colorectal cancer.

In a second study, Bethany L. Niell and Stephen B. Gruber, M.D., Ph.D., of the University of Michigan, Ann Arbor, and their colleagues performed genetic testing on 1,422 patients with colorectal cancer and 1,566 control subjects without colorectal cancer in a population-based study in Israel. They also found no association between the presence of a BRCA mutation and the risk of colorectal cancer.

A family history of breast cancer in a female relative was not associated with an increased risk of colorectal cancer, even after adjusting for the presence of a BRCA founder mutation. The authors conclude that Ashkenazi BRCA founder mutations do not confer a strongly elevated risk of colorectal cancer. Similarly, a family history of breast cancer does not appear to be a strong risk factor for
'"/>

Contact: Katherine Arnold
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
6-Jan-2004


Page: 1 2

Related biology news :

1. Genetic mutations linked to the practice of burning coal in homes in China
2. Rare mutations can significantly increase risk factor for heart disease
3. The mother lode of mutations
4. Mastectomy dramatically reduces breast cancer risk among women with BRCA1/2 mutations
5. Yeast mutations offer window into human disease
6. Ancient DNA mutations permitted humans to adapt to colder climates, UCI researchers find
7. BRCA mutations do not increase risk of colorectal cancer
8. Researchers describe novel gene mutations associated with Alzheimer disease
9. Major mutations, not many small changes, might lead way to new species
10. Genetics mutations resulting in delayed puberty are focus of MCG study
11. Gene mutations that cause hearing loss discovered

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/4/2017)... 4, 2017  CES 2017 – Valencell , ... today announced the launch of two new versions ... highly-accurate biometric sensor modules that incorporate the best ... and expertise. The two new designs include Benchmark ... hearables, and Benchmark BW2.0, a 2-LED version of ...
(Date:12/20/2016)... Dec, 20, 2016   Valencell , the ... and STMicroelectronics (NYSE: STM), a global semiconductor ... applications, announced today the launch of a new, ... wearables that includes ST,s compact SensorTile ... biometric sensor system. Together, SensorTile and Benchmark ...
(Date:12/15/2016)... VANCOUVER, Canada and BADEN-BADEN, Germany ... Solutions, a leading global financial services provider, today announced an ... in passive behavioural biometrics, to join forces. The partnership will ... fraud mitigation strategies in compliance with local data protection regulation. ... In ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... ... January 18, 2017 , ... LabRoots , ... from around the world, was today awarded the "Best Science & Technology Social ... on merit and decided upon by a dedicated team of researchers and analysts. ...
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... ... organization with services spanning the full spectrum of drug and device development, and ... services to pharma/device companies and clinicians, today announced Verified Clinical Trials ...
(Date:1/19/2017)... Jan. 18, 2017  Northwest Biotherapeutics, Inc. (OTCQB: NWBO) ... immune therapies for operable and inoperable solid tumor cancers, ... Technical Officer of NW Bio, will present at the ... at the Hyatt Regency Hotel in Miami, ... the session entitled "New Therapeutic Approaches – Expanding the ...
(Date:1/19/2017)... BD (Becton, Dickinson and Company) (NYSE: BDX ), a ... live webcast of its Annual Meeting of Shareholders on Tuesday, January ... can be accessed from the BD corporate website at http://www.bd.com/investors/ ... ... BD is a global medical technology company that is ...
Breaking Biology Technology:
Cached News: