HOME >> BIOLOGY >> NEWS
Bacterial Protein Structure Hints At Mechanism Of A Class Of Premature Aging Diseases

DURHAM, N.C -- Using a bacterial model system, scientists at Duke University Medical Center have determined the first step in understanding how a new class of genetic flaws may translate into diseases.

Deepak Bastia and Steven White, professors of microbiology at Duke, have determined how a protein, called a replication termination protein (RTP), stops DNA replication in the bacterium Bacillus subtilis, a common experimental organism.

Rather than simply acting as a roadblock to replication, as had been previously thought, RTP is more like a one way door, allowing the DNA replication machinery to move in only one direction along the DNA strand, the researchers said. They said the work has implications for human disease because RTP interacts with a class of proteins known as helicases, which have been shown to be involved in several genetic diseases. Bastia is now starting work on identifying the comparable protein in humans.

The researchers' findings appear in the Nov. 29 issue of the journal Cell. The research was funded by the National Institutes of Health.

RTP has been known to exist for 20 years, but it wasn't until two years ago that its structure was revealed by Bastia and White. "This [recent] work relates structure to function and takes us one step further in understanding how RTP works," Bastia said.

When DNA replicates, it unzips, starting and ending at specific sites. The helicases are responsible for pulling apart the DNA strands, which are twisted in a helical pattern. "RTP ensures that when DNA replicates, it is brought to a neat and accurate finish, and the cell knows that it is time to divide into two," White said.

Recently, helicase malfunction has been found responsible for a class of genetic diseases including Werner's syndrome and Cockayne's syndrome, premature aging syndromes; Bloom's syndrome, a type of dwarfism; and some kinds of skin cancer. Understanding of
'"/>

Contact: Karyn Hede George
georg016@mc.duke.edu
919-660-1301
Duke University
29-Nov-1996


Page: 1 2 3

Related biology news :

1. Bacterial protein recycling factor possible key to new class of antibiotics
2. Bacterial relationships revealed
3. Bacterial viruses make cheap easy vaccines
4. Bacterial infections alter allergic response
5. Bacterial alterations source of persistent COPD lung infections
6. Bacterial quorum-sensing structure solved
7. Bacterial control of zebra mussels, low power radio
8. Bacterial proteins cause autoimmunity in the antiphospholipid syndrome
9. Bacterial communities found to follow water
10. Bacterial strain may help clean up harmful industrial waste
11. The Largest Bacterium: Scientist Discovers New Bacterial Life Form Off The African Coast

Post Your Comments:
(Date:7/29/2014)... New research from scientists at the University of Kent ... inside cells are regulated a breakthrough that could ... A team from Kent,s School of Biosciences uncovered the ... within cells known as actin filaments are ... these actin filaments appear to completely stable, providing a ...
(Date:7/29/2014)... breaking new book that brings together two of the ... the profile of insect fossils through stunning photographs and ... and James E Jepson, details the incredible preservation and ... the scene for what these remarkable fossils can tell ... the future of our planet. Like the mosquito in ...
(Date:7/28/2014)... U.S. Food and Drug Administration (FDA) for other purposes ... inside human cells, including those that cause Legionnaires, disease, ... mBio , the online open-access journal of the ... identifying non-antibiotic drugs that could one day help curb ... the list inhibit the growth of at least three ...
Breaking Biology News(10 mins):Unique images bring fossil insects back to life 2New route to identify drugs that can fight bacterial infections 2
(Date:7/29/2014)... (PRWEB) July 29, 2014 TransVac Solutions, ... linen collection and transport solutions for hospitals, will be ... Healthcare Engineering (ASHE) Annual Conference & Technical Exhibition Aug. ... present its technology for making hospitals cleaner, reducing infection ... over the hospital’s life cycle. Staff will be ...
(Date:7/29/2014)... Philadelphia’s newest entrepreneurial incubation space is ready ... The Innovation Center @3401 , a collaborative effort of ... Center to help attract and nurture start-up businesses in ... , The Innovation Center @3401 (ic@3401), which ... is the new home of DreamIt Ventures and ...
(Date:7/29/2014)... July 29, 2014  Sigma-Aldrich Corporation (NASDAQ: ... use, increased its investment in Green Chemistry and donated ... world last year, the Company announced Monday in its ... Changed the World? The report comes ... for being a responsible corporate citizen, including recognition for ...
(Date:7/29/2014)... July 29, 2014 Quorum Review ... has been awarded accreditation by the International ... its Lean Six Sigma Deployment Program. The citation ... improve performance. , Quorum’s Lean Six Sigma program ... Deployment Program designation. The designation is a public ...
Breaking Biology Technology:TransVac Presents Cost Saving Technology at ASHE Conference for Keeping Hospitals Cleaner 2Innovation Center @3401 Opens for Business; DreamIt Ventures and Point.io First Residents 2Innovation Center @3401 Opens for Business; DreamIt Ventures and Point.io First Residents 3Sigma-Aldrich Achieves Record Success in Environmental, Community Initiatives 2Sigma-Aldrich Achieves Record Success in Environmental, Community Initiatives 3Quorum Review IRB Accredited by IASSC for Lean Six Sigma Deployment Program 2Quorum Review IRB Accredited by IASSC for Lean Six Sigma Deployment Program 3
Cached News: