HOME >> BIOLOGY >> NEWS
Bacterial infections alter allergic response

Researchers at National Jewish Medical and Research Center have gathered strong experimental support for the hygiene hypothesis, a proposed explanation for the worldwide rise in asthma and allergies. The research team, led by Richard Martin, M.D., found that early infection with the bacterium Mycoplasma pneumoniae reduced a mouse's subsequent response to allergens. Alternatively, mice exposed to allergens prior to infection, developed a stronger allergic response. The research team is reporting its results in the March 2003 issue of the journal Infection and Immunity.

"For the first time, we have shown that a bacterial infection can modify the allergic response," said Dr. Martin, Vice Chair of the Department of Medicine at National Jewish. "Timing is everything, however. Our results suggest that M. pneumoniae, or a related pathogen, could help prevent asthma and other allergic diseases, but only if the infection occurs before a person is sensitized to an allergen."

Asthma and allergies have both been on the rise for several decades, especially in developed countries. The hygiene hypothesis has offered one explanation for this increase: compared with the past, children living in these countries today are exposed to fewer infectious organisms, which are necessary to properly train their developing immune systems. As a result, their immune systems overreact to relatively harmless irritants, leading to allergies and asthma.

So far, however, most evidence both for and against the hygiene hypothesis has been indirect and observational. The National Jewish research team sought more direct evidence using a mouse model of asthma and the bacterium M. pneumoniae, a common cause of community-acquired pneumonia.

In their study, Martin and his colleagues inoculated mice with either the bacterium or with a saline solution. Then all the mice were made allergic to the egg protein ovalbumin. Two weeks later, the mice were then exposed to the ovalbumin
'"/>

Contact: William Allstetter
allstetterw@njc.org
303-398-1002
National Jewish Medical and Research Center
25-Feb-2003


Page: 1 2

Related biology news :

1. Bacterial protein recycling factor possible key to new class of antibiotics
2. Bacterial relationships revealed
3. Bacterial viruses make cheap easy vaccines
4. Bacterial alterations source of persistent COPD lung infections
5. Bacterial quorum-sensing structure solved
6. Bacterial control of zebra mussels, low power radio
7. Bacterial proteins cause autoimmunity in the antiphospholipid syndrome
8. Bacterial communities found to follow water
9. Bacterial strain may help clean up harmful industrial waste
10. The Largest Bacterium: Scientist Discovers New Bacterial Life Form Off The African Coast
11. Gene Discovery Paves Way For Preventing Deadly Bacterial Shock

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Bacterial infections alter allergic response

(Date:12/3/2014)... 2, 2014   Marvin Test Solutions , ... solutions for military, aerospace, and manufacturing organizations, today ... successful TS-900 PXI semiconductor test platform . ... high-end systems to customers at a fraction of ... traditional ATE. "Our semiconductor customers ...
(Date:11/21/2014)... , Nov. 20, 2014 Strict laws against ... are piloting the North American and European automotive sector ... growing, gesture recognition systems that are intuitive and able ... in the industry. New analysis from ... Recognition Market in Europe and ...
(Date:11/18/2014)... Nov. 17, 2014   News ... collaborate to develop The Partners Data Lake, an ... Partners Data Lake will allow researcher and clinicians ... treatment and the lives of patients , ... clinical activities across the Partners system, breaking down ...
Breaking Biology News(10 mins):Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5
(Date:12/19/2014)... The empty capsules market is experiencing growth ... technological innovations in the empty capsules market. The ... growth of the empty capsules market. , Get ... of Report , The report will enrich both ... to gauge the pulse of the market which ...
(Date:12/19/2014)... -- Decision Resources Group finds that the Asia ... through 2023 as the aging population, increasing adoption of ... all spur procedure volumes. Growth will be particularly rapid ... and India , where rising ... a larger proportion of the population. Other ...
(Date:12/19/2014)... , Dec. 18, 2014   ISN ... & Safety Performance Indicators publication series. With ... of activity reported in 2013 within its online contractor ... and safety key performance indicator (KPI) statistics. ... Clients, U.S. publication is available in two ...
(Date:12/17/2014)... The Activated Carbon Manufacturing industry ... IBISWorld updated its original industry research report. , ... intensified focus on environmental policy. Over the five years ... power plants and a range of other industrial facilities ... Sarah Kahn, “a range of downstream industrial sectors rely ...
Breaking Biology Technology:Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 3Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 4Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 3ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 3
Cached News: