HOME >> BIOLOGY >> NEWS
Bacterial infections alter allergic response

Researchers at National Jewish Medical and Research Center have gathered strong experimental support for the hygiene hypothesis, a proposed explanation for the worldwide rise in asthma and allergies. The research team, led by Richard Martin, M.D., found that early infection with the bacterium Mycoplasma pneumoniae reduced a mouse's subsequent response to allergens. Alternatively, mice exposed to allergens prior to infection, developed a stronger allergic response. The research team is reporting its results in the March 2003 issue of the journal Infection and Immunity.

"For the first time, we have shown that a bacterial infection can modify the allergic response," said Dr. Martin, Vice Chair of the Department of Medicine at National Jewish. "Timing is everything, however. Our results suggest that M. pneumoniae, or a related pathogen, could help prevent asthma and other allergic diseases, but only if the infection occurs before a person is sensitized to an allergen."

Asthma and allergies have both been on the rise for several decades, especially in developed countries. The hygiene hypothesis has offered one explanation for this increase: compared with the past, children living in these countries today are exposed to fewer infectious organisms, which are necessary to properly train their developing immune systems. As a result, their immune systems overreact to relatively harmless irritants, leading to allergies and asthma.

So far, however, most evidence both for and against the hygiene hypothesis has been indirect and observational. The National Jewish research team sought more direct evidence using a mouse model of asthma and the bacterium M. pneumoniae, a common cause of community-acquired pneumonia.

In their study, Martin and his colleagues inoculated mice with either the bacterium or with a saline solution. Then all the mice were made allergic to the egg protein ovalbumin. Two weeks later, the mice were then exposed to the ovalbumin
'"/>

Contact: William Allstetter
allstetterw@njc.org
303-398-1002
National Jewish Medical and Research Center
25-Feb-2003


Page: 1 2

Related biology news :

1. Bacterial protein recycling factor possible key to new class of antibiotics
2. Bacterial relationships revealed
3. Bacterial viruses make cheap easy vaccines
4. Bacterial alterations source of persistent COPD lung infections
5. Bacterial quorum-sensing structure solved
6. Bacterial control of zebra mussels, low power radio
7. Bacterial proteins cause autoimmunity in the antiphospholipid syndrome
8. Bacterial communities found to follow water
9. Bacterial strain may help clean up harmful industrial waste
10. The Largest Bacterium: Scientist Discovers New Bacterial Life Form Off The African Coast
11. Gene Discovery Paves Way For Preventing Deadly Bacterial Shock

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... LOS ANGELES , March 30, 2017  On ... Hack the Genome hackathon at ... This exciting two-day competition will focus on developing health ... experience. Hack the Genome is ... has been tremendous. The world,s largest companies in the ...
(Date:3/29/2017)... -- higi, the health IT company that operates the largest ... , today announced a Series B investment from BlueCross ... new investment and acquisition accelerates higi,s strategy to create ... health activities through the collection and workflow integration of ... and secures data today on behalf of over 36 ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed Anwar ... the prestigious international IAIR Award for the most innovative high security ePassport ... ... Maldives Immigration Controller General, Mr. ... on the right) have received the IAIR award for the "Most innovative ...
Breaking Biology News(10 mins):
(Date:7/26/2017)... ... July 26, 2017 , ... NLP Logix today ... of diagnostic excellence by Mayo Clinic and the experience in developing and deploying ... distributed through the Microsoft Azure platform and will focus on assisting physicians to ...
(Date:7/25/2017)... ... July 25, 2017 , ... Fiberstar, Inc ., a global ... offers Citri-Fi® 125. This natural citrus fiber is used to improve tomato-based food products ... in sauces, condiments and spreads. Today, more than ever, consumers connect ingredients to the ...
(Date:7/24/2017)... BALTIMORE , July 24, 2017 Intralytix, ... equity funding from Lesaffre, a French family group. This ... both companies to develop and commercialize bacteriophage-based products, for ... of mutual interest. ... fermentation, Lesaffre designs manufactures and markets innovative solutions for ...
(Date:7/20/2017)... (PRWEB) , ... July 20, 2017 , ... ... online directory of leading radiology and imaging centers around the U.S. that offer ... and highly accurate alternative to needle biopsy for staging liver fibrosis assessment. ...
Breaking Biology Technology:
Cached News: