HOME >> BIOLOGY >> NEWS
Bacterial quorum-sensing structure solved

ITHACA, N.Y. -- A decade after microbiologists began to suspect that many groups of bacteria can communicate -- by releasing and detecting chemical pheromones to gauge their population density -- the molecular structure of a key protein in this interbacterial communication has been solved.

This discovery could be the first step toward human intervention in these signaling pathways, a phenomenon known as quorum sensing, either by thwarting activities of harmful bacteria or facilitating activities of helpful ones. The work is reported by researchers at Cornell University, Argonne National Laboratory and Monsanto Co. in the latest edition of the journal Nature (June 27, 2002).

"There are many examples of bacterial processes that are effective only when carried out by large numbers of bacteria acting in a coordinated fashion, and coordination of behavior requires a communication system," explains Stephen C. Winans, professor of microbiology at Cornell. "One example of coordinated behavior is the formation of biofilms, which are mats of immobile bacterial cells stuck to a solid surface. Biofilms are ubiquitous in nature and can be harmful in some cases and beneficial in others. A deeper understanding of signaling could improve our ability to intervene in these and other processes."

He notes that one kind of bacterial biofilm smothers the lungs of cystic fibrosis victims. Knowing the configuration of an essential quorum-sensing protein might permit structure-based design of a drug to block the chemical signal before bacteria join in a drug-resistant biofilm. Conversely, the rapid formation of useful biofilms, such as biofilters to clean water or biobarriers to contain contamination, might be encouraged now that biologists know, in precise structural detail, what the quorum-sensing signal needs to proceed.

Molecular census-taking also is thought to occur in more than 70 other types of microorganisms, including bioluminescent bacteria, which tog
'"/>

Contact: Roger Segelken
hrs2@cornell.edu
607-255-9736
Cornell University News Service
26-Jun-2002


Page: 1 2 3

Related biology news :

1. Bacterial protein recycling factor possible key to new class of antibiotics
2. Bacterial relationships revealed
3. Bacterial viruses make cheap easy vaccines
4. Bacterial infections alter allergic response
5. Bacterial alterations source of persistent COPD lung infections
6. Bacterial control of zebra mussels, low power radio
7. Bacterial proteins cause autoimmunity in the antiphospholipid syndrome
8. Bacterial communities found to follow water
9. Bacterial strain may help clean up harmful industrial waste
10. The Largest Bacterium: Scientist Discovers New Bacterial Life Form Off The African Coast
11. Gene Discovery Paves Way For Preventing Deadly Bacterial Shock

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Bacterial quorum sensing structure solved

(Date:10/28/2014)... differences in moving activity in a novel environment ... angling, according to an experimental study completed at ... Game and Fisheries Research Institute. The study used ... and authentic angling trials to analyse if behaviours ... reared in traditional and enriched hatchery rearing environments. ...
(Date:10/28/2014)... and citrus fruits and juices are associated with a ... research from the University of East Anglia (UEA). ... foods containing flavonols and flavanones (both subclasses of dietary ... cancer, the fifth-leading cause of cancer death among women. ... of 171,940 women aged between 25 and 55 for ...
(Date:10/27/2014)... are an indigenous species of the West Antarctic Peninsula ... Earth. Since 1950, the average annual temperature in the ... and 6 degrees Celsius during winter. , As ... dry, polar system to a warmer, sub-polar system with ... a connection between local weather conditions and the weight ...
Breaking Biology News(10 mins):Fish 'personality' linked to vulnerability to angling 2Tea and citrus products could lower ovarian cancer risk, new UEA research finds 2University of Delaware study connects penguin chick weights to local weather conditions 2University of Delaware study connects penguin chick weights to local weather conditions 3
(Date:10/30/2014)... 2014 Spartan Bioscience announced today that ... System . It detects CYP2C19 genetic mutations in less ... The Spartan RX CYP2C19 System is the first near-patient ... in Canada. Due to the system’s ease of use, ... by healthcare professionals such as doctors, nurses, pharmacists, and ...
(Date:10/30/2014)... , Oct. 30, 2014 A new report, ... Partnership Practice, takes an in-depth look at ... that have resulted over two different time frames: 1993 ... a view of future opportunities for investment growth.  The ... report shows gains in innovation dollars as ...
(Date:10/27/2014)... October 27, 2014 The new ... Type (High & Medium), Sub-type (Primary & Secondary), ... Infrastructure & Transportation & Power Generation) - Trends ... GIS market with analysis and forecasting of the ... Data Tables with 52 Figures spread through 146 ...
(Date:10/27/2014)... MA (PRWEB) October 27, 2014 ... profit. SoundConnect , an industry leading unified ... its partners and agents to deliver cloud-based audio ... accelerate growth opportunities. , With SoundConnect’s Q4 ... every twenty-five video and/or web conferencing licenses sold, ...
Breaking Biology Technology:Health Canada approves first near-patient DNA test for personalized medicine 2Health Canada approves first near-patient DNA test for personalized medicine 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 2New report shows Indiana's gains in life sciences innovation capital outpace the nation 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 4New report shows Indiana's gains in life sciences innovation capital outpace the nation 5Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 3Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 4SoundConnect Unveils Q4 Partner Incentives 2
Cached News: