HOME >> BIOLOGY >> NEWS
Bacteria's natural foe fights drug-resistant infections

in nursing homes and day-care centers, where drug-resistant strains thrive.

Until now, there has been no strategy to remove the reservoir of S. pneumoniae from the noses and throats of humans. Yet, this "home base" provides an excellent target for controlling infections.

"This enzyme will kill pneumococci on mucous membranes within seconds," says Jutta Loeffler, M.D., first author of the paper and a postdoctoral fellow at Rockefeller. "By treating individuals carrying this bacterium with the enzyme, you could significantly reduce the reservoir of these bugs in the population and consequently reduce infection rates."

Such a decline in the number of worldwide infections would lessen the need for traditional antibiotics and subsequently ease the mounting drug-resistance problem.

Bacteriophage, or phage, can be found just about anywhere: in sewage and soil and any other locations where bacteria are found. As part of their normal lifecycle, these tiny viruses infect, replicate, then burst out of bacteria before infecting their next host.

Special phage enzymes, which punch holes in the bacterial cell wall, ensure the phage a rapid exit; without this outer layer of protection the bacteria essentially cannot hold themselves together, and, they explode.

Fischetti discovered that the phage enzymes also work when applied to the outside of the bacterial cells: by adding a few drops of phage enzyme to a test tube of millions of bacteria, he found that he could kill nearly all of them within a few seconds.

Because phage enzymes are specific for the species or strain of bacterium from which they were produced, cultivating a tailor-made killer for any bacterium of interest may be possible. Last February, for example, Fischetti and colleagues reported the isolation of a phage enzyme specific for Group A streptococci, an infectious pathogen that causes strep throat and flesh-eating disease. Human clinical trials testing the
'"/>

Contact: Whitney Clavin
clavinw@rockefeller.edu
212-327-7900
Rockefeller University
6-Dec-2001


Page: 1 2 3 4

Related biology news :

1. Bacterias iron-absorbing mechanisms may open gates for new types of antibiotics
2. Posters highlight water, energy and other natural resource research
3. Hunting illusive signs of natural selection
4. University of Arizona licenses patent for natural fungicide
5. Improving crops without genetic modification natural variation holds the key
6. Using statistics to decipher secrets of natural mutation
7. New designed paclitaxel analog kills more cancer cells than natural product
8. After natural disasters, the risk of infection, epidemics from dead bodies is negligible
9. Pearly mussels: One of North Americas natural jewels is disappearing
10. Unnatural light-dark cycles expose duelling circadian clocks
11. St. Jude researchers create image of enzyme that orchestrates natural genetic engineering

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... , March 23, 2017 The report "Gesture Recognition and ... Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, the market ... CAGR of 29.63% between 2017 and 2022. Continue ... ... ...
(Date:3/22/2017)... March 21, 2017 Vigilant Solutions , ... law enforcement agencies, announced today the appointment of retired ... of public safety business development. Mr. Sheridan ... experience, including a focus on the aviation transportation sector, ... recent position, Mr. Sheridan served as the Aviation Liaison ...
(Date:3/13/2017)... -- Future of security: Biometric Face Matching software  ... ... Face Matching enables to match face pictures against each other or against large ... Identification Systems) ... is the fastest software for biometric Face Matching on the market. The speed ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... ... Cambridge Semantics , the leading provider of Big Data management and analytics ... in Boston May 23-25 with a featured speaker and solution demos of its ... also a finalist for the Best of Show award. , James LaPointe, Managing Director ...
(Date:5/21/2017)... ... May 19, 2017 , ... Ovation Fertility ... the American Association of Bioanalysts (AAB) and the College of Reproductive Biology (CRB) ... reinforces AAB’s commitment to excellence in clinical laboratory services and regulations. , ...
(Date:5/18/2017)... ... May 18, 2017 , ... Lajollacooks4u has added another ... a two-hour team-building package designed for groups of 10-30 people. Guests can ... include items, such as Blackened Shrimp with Edamame Salad, Pizza Rolls with Pepperoni ...
(Date:5/18/2017)... ... May 17, 2017 , ... ... optimization firm for the life sciences and healthcare industries, is honored that ... for Medical Devices conference in Brussels, Belgium. , Crowley played a crucial role ...
Breaking Biology Technology:
Cached News: