HOME >> BIOLOGY >> NEWS
Bad news for pathogenic bacteria: Scientists find protein essential for bacterial survival

COLUMBUS, Ohio Further investigation into how the common organism Escherichia coli regulates gene expression has given scientists new ideas for designing antibiotics that might drastically reduce a bacterium's ability to resist drugs.

The findings, reported in the current issue of the journal Cell, suggest that bacteria rely on a key protein in order to properly regulate gene expression a process fundamental to cell survival.

This protein, called DksA, coordinates the expression of numerous genes in response to environmental signals.

Figuring out how to block DksA production in harmful bacteria may help scientists develop antibiotics that these bacteria are less likely to resist, said Irina Artsimovitch, a study co-author and an assistant professor of microbiology at Ohio State University.

The current study suggests that DksA is the glue that holds together two key components of bacterial gene expression a molecule called ppGpp and an enzyme called RNA polymerase. RNA polymerase carries out transcription, the first step in gene expression.

In recent work, Artsimovitch and her colleagues discovered that ppGpp regulates gene expression by controlling amino acid production in bacteria. A cell makes ppGpp when amino acid levels are low, and ppGpp tells a cell to go dormant until amino acid levels return to normal.

"But there was something missing from the ppGpp story," Artsimovitch said. "We knew that ppGpp had a dramatic effect on gene expression, but for some reason that effect was drastically decreased when we conducted experiments in the laboratory."

Work by other researchers had suggested a link between DksA and the ppGpp-initiated stress response in the cell. But scientists couldn't agree on what role, if any, DksA played in the effect of ppGpp on gene expression.

Working with a team of researchers led by Dmitry Vassylyev, a scientist with the RIKEN
'"/>

Contact: Irina Artsimovitch
artsimovitch.1@osu.edu
614-292-6777
Ohio State University
5-Aug-2004


Page: 1 2

Related biology news :

1. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
2. Asian bird flu became highly pathogenic through continued circulation and gene swapping
3. NETs protect against pathogenic bacteria
4. Genomic analysis of pathogenic and benign gastritis bacteria
5. Symposium explores antibiotic-resistant bacteria: sources and strategies
6. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
7. Scientists sequence genome of kind of organism central to biospheres carbon cycle
8. Scientists find nanowires capable of detecting individual viruses
9. Scientists discover potential new way to control drug-resistant bacteria
10. Scientists explore genome of methane-breathing microbe
11. Scientists decipher genetic code of biothreat pathogen

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/31/2019)... ... May 29, 2019 , ... FileWave, the multi-platform endpoint management ... launch of version 13.1. The new version extends FileWave’s mobile device management features ... spring release functionality. Version 13.1 builds on FileWave’s version 13 that was released ...
(Date:5/31/2019)... ... 30, 2019 , ... Join Julie Peacock, Vice President of ... Wednesday, June 19, 2019 at 1pm EDT where she will demonstrate how role-based ... and contract research organizations (CROs) can improve collaboration, auditing, document tracking and reporting. ...
(Date:5/31/2019)... ... May 31, 2019 , ... The OilComm Conference & ... announced today that Ben Reiter, Senior Writer at Sports Illustrated and Author of ... , Reiter predicted the Houston Astros would win the MLB championship in 2014 ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... BOSTON (PRWEB) , ... May 30, 2019 , ... ... Current regulatory thinking on Data Integrity on July 08-09, 2019 in Boston, MA. ... pharmaceutical, biotech and medical device organizations. , The training will kick off with ...
(Date:5/15/2019)... HERSHEY, Pa. (PRWEB) , ... May 15, 2019 , ... ... the Year in recognition for his work within the biomedical industry, where he is ... and improved medical devices. , “William Harding epitomizes the vision of our founders ...
(Date:5/7/2019)... British Columbia (PRWEB) , ... May 06, 2019 ... ... be a go-to resource for the growing number of repositories being asked to ... We are grateful to the team of contributors who are world leaders, who ...
(Date:5/2/2019)... ... 2019 , ... Stay on top of current hot topics through free webinars ... all webinars is free, so be sure to register today to save your place! ... to see our upcoming webinars: , CLINICAL TRIALS , May 7 – Oncology ...
Breaking Biology Technology:
Cached News: